Inspiring! Let’s keep the pressure on and call Congress.

Mark Peifer (He, him)@peiferlabunc.bsky.social · 3w ago

Let's learn a lesson from the nearly 500K of us who mobilized to comment on the OMB rules. We can leave the sidelines, take action and it can make a difference. After 15 months of inaction, our scientific societies finally woke up and mobilized members. It doesn't stop there 1/n

Happy to share the latest work from the lab, led by @mudgal17.bsky.social‬, in collaboration with the Weis lab @ethzurich.bsky.social. How do nuclear membranes fuse during NPC assembly? We answer this question in our latest work, where we identify a new mechanism for membrane fusion… (1/13)

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · last yr.

A conserved mechanism of membrane fusion in nuclear pore complex assembly https://www.biorxiv.org/content/10.1101/2025.07.21.665908v1

For the last 5 years, my lab has focused on developing mutational scanning methods and learning how to answer specific questions in protein biology. @matthewkhoward.bsky.social and I wrote a review on experimental decisions and future directions for our nascent field! doi.org/10.1146/annu...

Mechanistic Mutational Scanning to Uncover the Secret Life of Proteins

Deep mutational scanning (DMS) has emerged as a transformative tool for dissecting individual protein function and broader cell biology. DMS methods enable comprehensive interrogation of sequence–func...

annualreviews.org

For all the #nucleus fans out there: We’re celebrating the latest @jcellsci.bsky.social Special Issue in a webinar hosted by the Nuclear Pore and Nuclear Transport webinar series. Join us to hear talks from Ayse Turkmen, @andrewdstephens.bsky.social & Ralph Kehlenbach. 🗓️13 July, 17:00 BST (UTC+1)

Journal of Cell Science Special Issue: Cell Biology of the Nucleus - FocalPlane

Journal of Cell Science Special Issue: Cell Biology of the Nucleus - News

focalplane.biologists.com

A lab coming of age milestone? We are on our second generation -80C freezer.

Hey #nucleus nerds, the JCS Special Issue on the Cell Biology of the Nucleus is now live! This was a pleasure to co-edit with Megan King @luskinglab.bsky.social.

Journal of Cell Science@jcellsci.bsky.social · last mo.

Our Special Issue: Cell Biology of the Nucleus is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows the posteriorly positioned nuclei (Nup50-mCherry - pink) of notochord cells in Ciona embryos. See article by Peng et al. journals.biologists.com/jcs/article/...

Let’s go!

Gregg Gonsalves@gregggonsalves.bsky.social · last mo.

By now, I think you get it. I'll keep posting until we get 10,000 letters to Congress on Russ Vought's mad power-grab to take over all federal grant making. Goodbye peer review & expert advice, welcome the commissars! Let's stop Russ together. Share, share, share! actionnetwork.org/letters/oppo...

After some good funding news, we are hiring! Looking for a postdoc to join our team and lead our explorations into transposon repression by the nuclear lamina. Check out the full ad on our lab website at buchwalter-lab.github.io/postdoc-ad.pdf + contact me to learn more!

W H A T ?

Reese Richardson@reeserichardson.bsky.social · 2mo ago

Thermo Fisher has now made public the company line, which is ?!??!?!??!?!?! you really gotta read it. cen.acs.org/research-int...

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

How much of Thermo Fisher’s antibody data has been manipulated?

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

reeserichardson.blog

Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.

Igor Ulitsky@igorulitsky.bsky.social · 9mo ago

A preprint‼️that's bound to ruffle some 🪶 "Widespread DNA off-targeting confounds studies of RNA chromatin occupancy" led by our Micah Goldrich and Louis Delhaye from Pieter Mestdagh in Ghent. TL;DR we show that many of lncRNA chromatin occupancy obtained are flawed www.biorxiv.org/content/10.1...

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic

Thank you gift from a trainee might suggest I am pretty loud about my love of peanut butter. 🥜

The Orange Cat Brain Atlas is here. 🧠🐈 Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."

A piece of good news for basic scientists in training!

I-75 Scientist@flscitriguy.bsky.social · 5mo ago

NIGMS is signed onto the F31 NOFO. grants.nih.gov/grants/guide...

Eww.

More Perfect Union@moreperfectunion.bsky.social · 5mo ago

Billionaire Marc Andreessen says he has "zero" introspection, and that the idea itself is a modern invention.

His Harvard Lab Was Thriving. Then Came the Cuts. www.nytimes.com/2026/03/13/u...

His Harvard Lab Was Thriving. Then Came the Cuts.

nytimes.com

“At the end of your life, who you are is the accumulation of the things you did. It’s not just about…money.”

Science Magazine@science.org · 5mo ago

Many of the scientists Jeffrey Epstein courted were already well-established and well-funded. So why didn’t they all just say no? Science talked with three who did just that. Here’s how Epstein approached them, and why they refused to have anything to do with him. ⬇️ https://scim.ag/40qbXnv

Congrats to all the Weintraub awardees! I spy UCSF’s own Ayush Midha on this list - very cool!

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org · 5mo ago

“These awardees stood out for their scientific originality, rigor and dedication to asking important scientific questions. They reflect the strength and promise of the next generation of scientific leaders.” - Dr. Bai, director of the Weintraub Award. www.fredhutch.org/en/news/rele...

New version of our preprint on bioRxiv about bioRxiv up. Now that’s what I call a revision – 6 years after the first version! It has new data about our progress and highlights from a massive user survey. 1/n www.biorxiv.org/content/10.1...

My lab @cri-utsw.bsky.social is looking for a highly motivated postdoct interested in mechanobiology! We are building a highly collaborative and interdisciplinary team working on how mechanical forces shape immune and cancer cell behavior. Come do cool science with me! lnkd.in/gKEXWUGy

Interested in transcriptional regulation, enhancers and 3D genome folding? In this new study we wondered about the role of cohesin loading at enhancers for long-range transcriptional control www.biorxiv.org/content/10.6... detailed 🧵👇

We are starting Bay Area Chromatin Club up again in 2026! Fist event March 5th at UCSF Mission Bay! Details and registration HERE: If you like to nominate a person for a talk- DM me. It's been a great experience in the past. urldefense.com/v3/__https:/...

We are calling our senators right now and demanding that they vote no on the omnibus with DHS funding We are explicitly mentioning ICE’s murder in cold blood of a man on the streets of Minneapolis this morning

The video abstract that accompanies this paper is a delight.

Alice Auersperg@auersperga.bsky.social · 7mo ago

Our new paper (with @biotay.bsky.social) is out and on the cover story of @currentbiology.bsky.social !!!! Veronika, a Carinthian mountain cow flexibly uses a “multi-purpose tool” to scratch herself. A video and more information will follow in the comments. www.cell.com/current-biol...

We saw Jan 6, 2021 and Jan 7, 2026 with our own eyes. This is not Orwell's 1984.

T-minus 1 month to abstract deadline for the CSHL Genome Organization 7 Nuclear Function meeting! Hope to see you there, my fellow #genome and #nucleus nerds. meetings.cshl.edu/meetings.asp...

I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...

Submit your latest research to our upcoming special issue: Cell Biology of the Nucleus. This issue is being coordinated by Abby Buchwalter @abbybuch.bsky.social, working alongside Megan King @luskinglab.bsky.social. Deadline: 5 January 2026 journals.biologists.com/jcs/pages/nu...