Charles D Cox

@charlesdcox.bsky.social

Former pharmacist | Australian Research Council Future Fellow & Faculty Victor Chang Cardiac Research Institute, Sydney, Australia | Truffle fanatic.

Beyond time that we started seeing articles like this about the appalling state of Australia’s grant funding system……and peer review is just one problem that needs fixing. Australia’s erosion of peer review | Science www.science.org/doi/10.1126/...

Australia’s erosion of peer review

Throughout the world, peer review serves as the cornerstone of the scientific enterprise, providing rigorous quality control and building the confidence that underpins progress for both science and so...

science.org

Looking for a cell line that natively expresses PIEZO2 - we’d say avoid MCC13. Unlike Merkel cells the native mechanically-evoked currents in this line are largely carried by PIEZO1. And like many other cell lines that we’ve tested the slow components come from MDFIC/MDFI tinyurl.com/3mmnwhpp

Understanding the molecular components of mechanically evoked currents in the Merkel cell line MCC13

Merkel cells are epithelial cells involved in the discrimination of light touch. Situated in the skin, these specialised cells decode mechanical cues through the mechanosensitive ion channel PIEZO2. M...

tinyurl.com

Not the greatest ride for this one but happy with the end result - a sensory neuron specific protein that regulates PIEZO1/2. Lots of cool things left to show with this protein! MDFIC2 is a sensory neuron–specific PIEZO channel auxiliary subunit | PNAS www.pnas.org/doi/10.1073/...

MDFIC2 is a sensory neuron–specific PIEZO channel auxiliary subunit | PNAS

PIEZO channels are critical for sensory mechanotransduction. While MyoD-family inhibitor proteins were identified as PIEZO1 auxiliary subunits, the...

pnas.org

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

cnn.com