Jenny Stow

@jennystowlab.bsky.social

Scientist, cells are beautiful, macrophages best, imaging, cytokines, Rabs. Love dogs of course, nature too.

Persistent underinvestment in Australian R&D by government and the business sector is now intolerable. Within five years, Australia will be at the bottom of the OECD – no place to be in a volatile and technologically advanced world where research - and the technologies it produces -

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The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death pathways

TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

science.org

Finally my first author preprint at Cullen's lab is out! Amazing collaboration with Kevin and @brettcollins.bsky.social where, by using dedicated proximity proteomics, Biochemistry, crystallography and structural prediction, we show new aspects of human Retromer complex acting as hub for RAB GTPases

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · 2y ago

Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation. https://www.biorxiv.org/content/10.1101/2024.11.22.622898v1