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Louise Cheng

@chengflylab.bsky.social

Drosophila lab based at Peter MacCallum Cancer Center, Melbourne, Australia. Interested in nutrition, cancer cachexia, neural development, environmental influences on organ size control. Chenglabcom.wordpress.com

5 Posts237 Follower287 Folgt
Louise Cheng@chengflylab.bsky.social · 11mo ago

Excited to share this work led by the talented @joannaqd.bsky.social. Thank you to our friends and collaborators @obataf-lab.bsky.social, Cyrille Alexandre, and members of the Cheng Lab @petermaccc.bsky.social

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talentedjoannaqd.bsky.social

PLOS Biology@plosbiology.org · 11mo ago

How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @chengflylab.bsky.social &co show that this is regulated by the SCL36 amino acid transporter Pathetic at the #BloodBrainBarrier perineural glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY

Left: Maximum projection images of elavC155QF>QUAS-prosRi tumor brains stained with Repo and Dpn. The animals were moved from standard food to chemically defined diet (CDD) (top left), CDD minus Leu (top right), CDD minus Ile (bottom left), and CDD minus Met (bottom right) at 72hALH and dissected at 120hALH. Right: Schematic depicting the working model. Nutrient Restriction (NR) inhibits BBB glia expansion, which consequently limits brain tumor growth. The authors show that NR inhibits the expression of fat body and glia-derived Ilp6, causing downregulation of the InR/PI3K pathway in BBB glia. This results in a reduction in Path expression and the downstream mTOR-S6K pathway, causing a slowdown of BBB glial cell cycle progression. Path downregulation and defects in BBB expansion consequently led to a decrease in brain AAs, such as Leu, which hinders brain tumor protein synthesis to slow down tumor growth. Data information: ALH, after larvae hatching.
Bülow Lab@buelowlab.bsky.social · last yr.

I am very excited to share our latest preprint on peroxisome-Golgi interaction in dilp secretion. Great work by lab members @kucharowski.bsky.social, the incredible Marie, @darladr.bsky.social, @buelowt.bsky.social and fantastic collaboration with @jan-ache.bsky.social-Lab and Kuerschner-lab

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bioRxivpreprint@biorxivpreprint.bsky.social · last yr.

Insulin-like peptide secretion is mediated by peroxisome-Golgi interplay https://www.biorxiv.org/content/10.1101/2025.05.26.656179v1