Fumiaki Obata
@obataf-lab.bsky.social
PI studying nutritional biology at RIKEN Center for Biosystems Dynamics Research & visiting associate professor in Kyoto University. Interested in Drosophila genetics, amino acid, nutrient, microbiota, metabolism, ageing, lifespan, and many others
Excited to share our work reporting that fly Lsp2 acts as a nutrient-induced physiological factor that amplifies mTORC1 output in TOP mRNA translation and regulates lifespan. www.nature.com/articles/s41...
Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila - Nature
In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of T...
nature.com
A fruit-fly protein thought only to store amino acids in fact responds to nutritional deficiency in both development and adulthood, resulting in lifespan extension go.nature.com/4d6rRdo
Surprising protein links dietary restriction to increased lifespan in flies
A fruit-fly protein thought only to store amino acids in fact responds to nutritional deficiency in both development and adulthood, resulting in lifespan extension.
go.nature.com
Our new study just out @nature.com Together with Koshi Imami @RIKEN IMS, Hina Kosakamoto found out the key molecule mediating lifespan extension by early life dietary restriction! www.nature.com/articles/s41...
Lsp2 links early-life diet to adult translation and lifespan in Drosophila - Nature
Isotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 as a key regulator of translation and lifespan that forms the molecular basis of the eff...
nature.com
Hina Kosakamoto@kosakamotohina.bsky.social · 2w agoExcited to share that our work from RIKEN is now published in Nature! 🎉 We uncovered how protein intake during development shapes lifespan and identified a mechanism that transmits a “nutritional memory” into adulthood. www.nature.com/articles/s41...
【採用情報】 理研BDRの栄養応答研究チーム (チームディレクター: 小幡史明)から、研究員または特別研究員の公募が出ています。 栄養に関する研究に興味のある方はぜひ！ 随時受付、審査を行い、ポストが埋まり次第締め切ります。 詳細は👇 www.riken.jp/careers/rese...
研究員または特別研究員募集 栄養応答研究チーム（25-1968）
riken.jp
New study from the lab posted to @biorxivpreprint.bsky.social PhD student Yuka discovered the beautiful mechanism for overcoming nutrient deficiency by microbiota and a new metabolic pathway! Dietary requirement of choline for phospholipids is very complicated www.biorxiv.org/content/10.6...
Dual Metabolic Compensation to Dietary Choline Deficiency by the Drosophila Hologenome
Coping with an unbalanced diet is critical in animals. However, the mechanisms that mitigate deficiencies of specific nutrients, such as choline, remain poorly understood. Choline is converted to phos...
biorxiv.org
Our new study out @BMC Biology. The first Mosquito study from the lab, driven by a great effort of phd student Yusuke Kato with the hard work of Chisako Sakuma. Amino acid economy meets a blood-sucking insect. link.springer.com/10.1186/s129...
Temporal changes in amino acid profiles coordinate mosquito physiology and egg maturation in Aedes aegypti - BMC Biology
Background Female Aedes aegypti mosquitoes utilize host blood to support egg maturation by digesting, absorbing, and metabolizing its components. Among these, amino acids are essential as both signali...
link.springer.com
a tiny contribution from my lab to the great work! Amino acid biology in tumour growth. Congrats! A pint ahead in Melbourne!
Louise Cheng@chengflylab.bsky.social · 11mo agoTagging first author @joannaqd.bsky.social and collaborators @obataf-lab.bsky.social
Tagging first author @joannaqd.bsky.social and collaborators @obataf-lab.bsky.social
Peter MacCallum Cancer Centre@petermaccc.bsky.social · 11mo ago🧠 New research shows the blood–brain barrier helps control #braintumour growth. Led by Prof Louise Cheng, the study finds glial “gatekeeper” cells and a protein called Path influence how #cancer respond to low nutrients. Read more: www.petermac.org/about-us/new...
How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @chengflylab.bsky.social &co show that this is regulated by the SCL36 amino acid transporter Pathetic at the #BloodBrainBarrier perineural glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY
Latest exciting work from me and @mirresimons.bsky.social (and the first bit of data from my @vivensa.bsky.social ECR Fellowship) now out as a preprint, looking at effects of knocking down individual spliceosome components on lifespan in vivo: www.biorxiv.org/content/10.1...
Knockdown of the fly spliceosome component Rbp1(orthologue of SRSF1) extends lifespan
Biological regulation is a highly intricate process and involves many layers of complexity even at the RNA level. Alternative splicing is crucial in the regulation of which components of a protein-cod...
biorxiv.org
New study out! We developed the protocol for dietary manipulation of protein and amino acids in marmoset! FGF21 induction and taurine drop observed. Achieved by intra-RIKEN collab and the first author Yuka's effort. Here comes Primate Nutritional Biology! www.nature.com/articles/s41...
Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels - Scientific Reports
Scientific Reports - Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels
nature.com
A long-standing mystery in the development of fly embryos has been resolved go.nature.com/4nhVxaa
Flies evolved a shock-absorber tissue used during embryonic development
The role of tissue that forms between the head and trunk of a fly embryo has been unclear. It turns out that it absorbs forces when nearby cells move and divide.
go.nature.com
「読み進めるほどに「腹八分目」という漠然とした言葉の奥深さが沁みてくる」 「江戸時代に「腹八分目」と言い表したヒト（貝原益軒）の直感にも感心する、楽しい読書だった」 8/24読売新聞で、奈倉有里さんが小幡史明『「腹八分目」の生物学』をご書評くださいました。☞ iwnm.jp/029735 お陰さまで売れています！
！重版決定！ 先月刊行された『「腹八分目」の生物学――健康長寿の食とはなにか』（http://iwnm.jp/029735）、早々に2刷が決定しました！ なお現在、一部ネット書店でカート落ちが発生しております。お近くのリアル書店などで、ぜひお探しいただけますと幸いです。 近日中に電子書籍版も配信開始予定ですので、そちらもぜひご利用ください🐭
Drosophila research without FlyBase would be untenable. Time for all labs who can afford it to step up.
Mark A. Hanson@hansonmark.bsky.social · last yr.A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate. www.philanthropy.cam.ac.uk/give-to-camb...
8/3産経新聞で、小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（iwnm.jp/029735）が紹介されました： 「気鋭の研究者による「食の科学」の一冊」 「生存戦略とも結びついた食の奥深さに驚かされる」 www.sankei.com/article/2025...
＜書評＞長寿のカギは「タンパク質の摂取量」 『「腹八分目」の生物学』小幡史明著
「腹八分目」の戒めは、江戸時代から『養生訓』などで広く知られた健康と長寿のための経験則。20世紀に入り、ラットやミジンコといった動物を使った実験でも、食事制限…
sankei.com
『「腹八分目」の生物学――健康長寿の食とはなにか』（iwnm.jp/029735）著者の小幡史明さんに、岩波書店本社へおいでいただきました！ ご著書と記念撮影です。 ただいま好評発売中。 腹八分目のかたも、つい食べ過ぎちゃうかたも、ぜひどうぞ。
#Throwback 🧪 COMMENT | Subcellular quantitative imaging of metabolites at the organelle level @siuzdak.bsky.social
Subcellular quantitative imaging of metabolites at the organelle level - Nature Metabolism
Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging, but was originally thought to be unattainable. However, recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality, thanks to the development of nano secondary ion mass spectrometry.
bit.ly
＼ 本日 ☆ 刊行 ／ 小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（岩波科学ライブラリー） 試し読みなどはこちら！ → iwnm.jp/029735 長寿の鍵となる栄養素とは。腹八分目で、老化そのものも防げるか。不老長寿の薬は……！？ 飽くなき探究をいきいきと伝える。 ※電子書籍は8月配信予定です。
📢 New preprint: “Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition” Led by @ameliejoly.bsky.social, co-supervised with @francoisleulier.bsky.social. We’re proud to share this story. 👉 www.biorxiv.org/content/10.1...
Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition
Dietary protein sufficiency during childhood is essential for healthy growth and tissue development. Chronic protein deficiency leads to stunting, height-for-age more than two standard deviations belo...
biorxiv.org
A new review from the lab is out. A phd student Ayano and me summerises the current view of amino acid signalling, revealed by Drosophila genetics. www.sciencedirect.com/science/arti...
Nutrient sensing and signalling of specific amino acids: Insights from Drosophila study
Maintaining amino acid (AA) homeostasis is necessary for organisms. To achieve this, organisms have evolved various signalling pathways regulated by s…
sciencedirect.com
Why use #CRISPR in #Drosophila when RNAi works so well? Because for some genes well is not good enough. Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens. www.biorxiv.org/content/10.1...
CRISPR mutagenesis is also not perfect. A common limitation is generation of genetic mosaics, where only some cells carry gene knockouts. But our new generation of tools substatially improves on that. Described in the preprint below with flies on their way to VDRC: www.biorxiv.org/content/10.1...
De novo serine biosynthesis is protective in mitochondrial disease: Cell Reports www.cell.com/cell-reports...
De novo serine biosynthesis is protective in mitochondrial disease
Jackson et al. show that serine becomes an essential amino acid in mitochondrial muscle disease, delaying disease progression. Blocking local biosynthesis of serine challenges cellular phospholipid ho...
cell.com
www.crick.ac.uk/news/2025-05... by Clare Green @crick.ac.uk
New stem cell model sheds light on human amniotic sac development
Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four wee...
crick.ac.uk
Taurine from tumour niche drives glycolysis to promote leukaemogenesis www.nature.com/articles/s41...
Taurine from tumour niche drives glycolysis to promote leukaemogenesis - Nature
The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.
nature.com
Calorie restriction extends lifespan in many animal models, but the effects in humans and the mechanisms of action are not clear. A Review in Nature Reviews Endocrinology summarizes evidence regarding potential adverse effects of calorie restriction. go.nature.com/42XV1Xa 🔒
