Jon Davidow
@choisi.bsky.social
Neurologist researching #consciousness #coma and #complexity in #Neurocriticalcare
What is the minimal machinery needed for complex, cognition-like behavior? With @lostintheswarm.bsky.social, we show how self-sustained calcium oscillations, diffusion, and mechanics may be enough to coordinate behavior across a single cell with no nervous system. www.biorxiv.org/content/10.6... 1/
Beautiful piece from one of the greatest thinkers on our explicit role in our understanding of the universe.
Earl K. Miller@earlkmiller.bsky.social · 6mo agoThere Is No Hard Problem of Consciousness www.noemamag.com/there-is-no-... #neuroscience
The brain is more than spiking neurons. Astrocytes, a large fraction of cells, propagate electrical influences without spiking. And cortical neurons spike only intermittently. Electrical signals are continuous and across all cells. #neuroscience www.quantamagazine.org/once-thought...
Once Thought To Support Neurons, Astrocytes Turn Out To Be in Charge | Quanta Magazine
New experiments reveal how astrocytes tune neuronal activity to modulate our mental and emotional states. The results suggest that neuron-only brain models, such as connectomes, leave out a crucial la...
quantamagazine.org
Relevant to all fields of Neurology (and Medicine, as Dr. Okun points out), including recovery from acute brain injury.
Michael Okun@michaelokun.bsky.social · 9mo agoCheck out my newest Substack column on bending the cause of Parkinson's disease through improved sleep. Spoiler alert: your brain's 'glymphatic system' is more than just plumbing. michaelokun.substack.com/p/can-we-ben...
Qin et al: Clinical Features and Outcomes in Adult Patients with Autoimmune Encephalitis Requiring Intensive Care: A Retrospective Cohort Study Link: link.springer.com/ar... @neurocritical #neurocritcare
"Awe-scillations": EEG spectral and complexity representations of awe https://www.biorxiv.org/content/10.1101/2025.11.20.689403v1
Heard at #SfN25 from @earlkmiller.bsky.social: Cognition and consciousness emerge from the dynamic organization of the cortex produced by traveling brain waves performing analog computations. picower.mit.edu/news/brain-w... #neuroscience #consciousness #cognition @mitbcs.bsky.social
Brain waves’ analog organization of cortex enables cognition and consciousness, MIT professor proposes at SfN
On neuroscience’s big stage Nov. 15, MIT Professor Earl K. Miller proposed that thought and consciousness emerge from the fast and flexible organization of the cortex produced by the analog computatio...
picower.mit.edu
The Erosion of Harm Reduction | New England Journal of Medicine www.nejm.org/doi/full/10....
The Erosion of Harm Reduction | NEJM
The U.S. administration has continuously chipped away at public health interventions addressing substance use disorders and the opioid crisis, including vital harm-reduction activities.
nejm.org
Human cortical dynamics of auditory word form encoding www.cell.com/neuron/fullt...
Human cortical dynamics of auditory word form encoding
Zhang, Leonard, et al. use high-density direct human brain recordings to reveal how the superior temporal gyrus (STG) detects word boundaries in natural speech and encodes whole auditory word forms. N...
cell.com
Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans | PLOS Biology journals.plos.org/plosbiology/...
Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans
Hemispherotomy is a neurosurgical procedure for treating refractory epilepsy by disconnecting a significant portion of the cortex. This study shows that the isolated cortex exhibits EEG patterns resem...
journals.plos.org
Today, a team of scientists led by Jordan DeKraker, Boris Bernhardt and Alan Evans published HippoMaps, an #openaccess toolbox and online data warehouse for the mapping and contextualization of subregional hippocampal data in the human brain. 🧠 rdcu.be/eI1ye
Lots of interesting implications…
Eiko Fried@eikofried.bsky.social · last yr.Intervening on a central node in a network likely does little given that its connected neighbors will "flip it back" immediately. Happy to see this position supported now. "Change is most likely [..] if it spreads first among relatively poorly connected nodes." www.nature.com/articles/s41...
Switching from 1% to 2% propofol in ICU sedation cut greenhouse gas emissions, waste, and costs, with savings equal to over seven Paris–New York flights annually, showing concentration adjustment as a path to greener critical care. zurl.co/DHWbi
Extremely inspiring start to #NCS2025 with a presentation of the RECOVER program and consortium, a beautiful multi-d approach to improve the clinical care of people in coma www.med.upenn.edu/recover-prog...
RECOVER Program Overview | Recovery of Consciousness Via Evidence-Based Medicine and Research (RECOVER) Program | Perelman School of Medicine at the University of Pennsylvania
Information about the Recovery of Consciousness Via Evidence-Based Medicine and Research (RECOVER) Program at the University of Pennsylvania.
med.upenn.edu
Interesting work helping to move from the subjective to the objective in psychedelic science.
Nature Reviews Neurology@natrevneurol.nature.com · last yr.Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors www.nature.com/articles/s41...
Practice changing systematic review and meta analysis, no evidence of symptomatic ICH with early DOAC: www.thelancet.com/journals/lan...
Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised contr...
For people with acute ischaemic stroke and atrial fibrillation, early DOAC initiation (within 4 days) reduced the risk of the composite outcome of recurrent ischaemic stroke, symptomatic intracerebral...
thelancet.com
ICYMI: New online! Autoimmune encephalitis-associated epilepsy
Autoimmune encephalitis-associated epilepsy
Nature Reviews Neurology, Published online: 02 May 2025; doi:10.1038/s41582-025-01089-4In this Perspective, the authors provide a detailed description of rare autoimmune encephalitic conditions that present with recurrent seizures that are resistant to immunotherapy, grouped under the term autoimmune encephalitis-associated epilepsy. The article considers the clinical characteristics and pathophysiological mechanisms of these conditions, alongside current knowledge of treatment and outcomes.
bit.ly
generalized convulsive status epilepticus update: feels like it's time to add IV ketamine as a 2nd line agent before intubation 👇 thoughts/opinions? rationale explained here: pubmed.ncbi.nlm.nih.gov/36609129/ evidence is accumulating eg, pubmed.ncbi.nlm.nih.gov/37610640/ #EMIMCC
Proud to share cases which might help to change the outcome for others bmcneurol.biomedcentral.com/articles/10....
Delayed diagnosis of basilar artery occlusion in a 28-year-old postpartum woman - BMC Neurology
Background Basilar artery strokes, which are often challenging to diagnose due to their diverse symptoms and uncommon occurrence, demand timely identification to mitigate severe consequences. Case pre...
bmcneurol.biomedcentral.com
www.cell.com/cell/fulltex... Lots of serotonergic neuroprotectantive agents to explore.
Serotonin reduction in post-acute sequelae of viral infection
Post-viral syndromes are associated with serotonin reduction, which may contribute to the neurological and cognitive symptoms seen in individuals with Long COVID.
cell.com