Love this! 🥹

Dirk Trauner@dirktrauner.bsky.social · 11h ago

Feeling down? Reviewer 3 was nasty? 13C-NMR doesn’t match? TLC shows an Autobahn? Tomorrow is another day. And our “Need Motivation” button is back! www.traunergroup.org

Thanks Johannes @morstein.bsky.social and your class for highlighting our MultiMap systems! This is an awesome format and I am learning a lot from this too!

Stephan Hacker@stephanhacker2.bsky.social · 2w ago

What are the hot topics in Chemical Biology? If you want to learn about the exciting perspective of students of Johannes Morstein's (@morstein.bsky.social) Ch/Bi145 course at @caltech.edu, you can now do so in their ChemBioChem review. doi.org/10.1002/cbic... (1/13) @chemistryeurope.bsky.social

Excited to share my first co-corresponding preprint in collaboration with @jimwellsucsf.bsky.social and Bill DeGrado, where we used de novo protein design to develop a photocatalytic proximity labeling enzyme EYClamp.

bioRxiv Biochemistry@biorxiv-biochem.bsky.social · last mo.

A de novo designed enzyme for photo-proximity labeling of E3 ligase neighborhoods in live cells https://www.biorxiv.org/content/10.64898/2026.07.22.739993v1

Excited to share the first study from the Morstein Lab on a new approach that enables selective editing, tagging, and visualization of mammalian lipids www.biorxiv.org/cgi/content/... #chembio #lipidtime @caltech.edu @caltechcce.bsky.social @harayamajrlab.bsky.social @logan-tenney.bsky.social

We are hiring a postdoc! The group has a funded opening to join our amazing team on the NCI's Frederick, MD campus. This is an opportunity to train in cutting-edge chemical & RNA biology methods with a supportive, tight-knit group. Link to posting below. Please share! jobrxiv.org/job/national...

Excited to share our newest paper on @natchembio.nature.com where we present temporal MultiMap for dynamic neighborhood mapping. Our sincere gratitude to all our collaborators for their hard work!

Gene Chong@chongg.bsky.social · 10mo ago

A new paper from @zhilindseylin.bsky.social @jimwellsucsf.bsky.social and colleagues presents temporal mapping of extracellular and intracellular neighborhoods of a protein of interest with MultiMap photoproximity labeling proteomics, here applied to EGFR www.nature.com/articles/s41...

Check out our review on DNA-scaffolded catalysis! This link provides free full text access until the end of 2025: authors.elsevier.com/a/1m43W9CpcY.... Big thanks to co-authors @edwardpimentel.bsky.social , Ashley Ogorek, @ethan-hartman-125.bsky.social , and Caleb Cox

Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr... New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale. 1/n

FlAsH-ID: A short peptide tag for live cell photoproximity labeling https://www.biorxiv.org/content/10.1101/2025.10.24.684417v1

Think you know how chemists look and act? Think again. Thanks to the incomparable @drdre4000.bsky.social for teaching and inspiring the #CASFutureLeaders and so many more in the chemistry community. @acs.org www.tiktok.com/t/ZPHGUB1xnE...

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

Super grateful to have this great experience at the Bioorganic Chemistry GRS! Thank you to my co-chair @ssmelyansky.bsky.social and everyone who attended for making it such a wonderful event! 🤩

Stephanie Smelyansky@ssmelyansky.bsky.social · last yr.

Last week, I had the privilege of chairing the Bioorganic Chemistry GRS with my amazing co-chair @zhilindseylin.bsky.social. Thank you to all of our amazing speakers, poster presenters for a truly incredibly GRS!

Look forward to our Bioorganic GRS+GRC in a few days! -> For those who are interested in hiring: I'll be setting up a job post bulletin at the GRS that hopefully will let our early-career scientists know about opportunities in your lab. If you’re interested, feel free to DM me your poster!

Jordan Meier@doc-jlmeier.bsky.social · last yr.

Bioorganic GRC is set! I got tired of the lack of swag so made a couple of unofficial tees. Order one if you want to support the conference (or simply enjoy strange looks in grocery stores). Spirit: chembio-shop.fourthwall.com/products/grc... World Tour: chembio-shop.fourthwall.com/products/spi...

Congrats Stephanie!!

Stephanie Smelyansky@ssmelyansky.bsky.social · last yr.

Excited to share that my first first author paper is now out in @pnas.org ! We show that we can use oxaziridines to label thioether containing glycans in Mtb. Using this approach we could visualize key glycans during model infection! www.pnas.org/doi/10.1073/...

An awesome opportunity!!

Luke Lavis@rhodamine110.bsky.social · last yr.

We're looking for 1-2 enthusiastic early career chemists to join our Open Chemistry team at @hhmijanelia.bsky.social. Come help us create amazing dyes and share them with the world. Please share with the best recent/soon-to-be B.S. chemists you know! bit.ly/42w8C6N

Excited to share that our cell surface proteome review is now online on Chemical Reviews! 🥰 We highlight recent advances of techniques mapping cell surface protein expression, protein-protein interactions, extracellular PTMs and MHC complexes. @jimwellsucsf.bsky.social pubs.acs.org/doi/10.1021/...

Engineered Proteins and Chemical Tools to Probe the Cell Surface Proteome

The cell surface proteome, or surfaceome, is the hub for cells to interact and communicate with the outside world. Many disease-associated changes are hard-wired within the surfaceome, yet approved drugs target less than 50 cell surface proteins. In the past decade, the proteomics community has made significant strides in developing new technologies tailored for studying the surfaceome in all its complexity. In this review, we first dive into the unique characteristics and functions of the surfaceome, emphasizing the necessity for specialized labeling, enrichment, and proteomic approaches. An overview of surfaceomics methods is provided, detailing techniques to measure changes in protein expression and how this leads to novel target discovery. Next, we highlight advances in proximity labeling proteomics (PLP), showcasing how various enzymatic and photoaffinity proximity labeling techniques can map protein–protein interactions and membrane protein complexes on the cell surface. We then review the role of extracellular post-translational modifications, focusing on cell surface glycosylation, proteolytic remodeling, and the secretome. Finally, we discuss methods for identifying tumor-specific peptide MHC complexes and how they have shaped therapeutic development. This emerging field of neo-protein epitopes is constantly evolving, where targets are identified at the proteome level and encompass defined disease-associated PTMs, complexes, and dysregulated cellular and tissue locations. Given the functional importance of the surfaceome for biology and therapy, we view surfaceomics as a critical piece of this quest for neo-epitope target discovery.

pubs.acs.org

Absolutely honored to be selected 2025 CAS Future Leaders! Congrats to all the cohort and I look forward to join you in upcoming events! 🥳

Peter Carlton@petercarlton.bsky.social · last yr.

Please join me in congratulating the 2025 #CASFutureLeaders! We look forward to welcoming these exceptional Ph.D. students and postdoctoral scholars to Columbus, Ohio, and Washington, DC, this August. www.cas.org/press-releas...

Really enjoyed this proximity-based therapeutics keystone conference! Appreciate the organizers Fleur @fleurmferguson.bsky.social and Phil for the opportunity and for putting together this wonderful event!

Keystone Symposia@keystonesymposia.bsky.social · 2y ago

Celebrate the scholarship winners from Proximity-Based Therapeutics: Markella Konstantinidou, @zhilindseylin.bsky.social, Charlene Mae Magtoto, Ashwini Premashankar, & Maximilian R. Stammnitz. Learn more about financial aid at keysym.us/KSFinancialAid. #keystonesymposia #keystoneconferences

Chembio trainees: Eager to see you all at this year’s Bioorganic GRS + GRC in June! Don’t forget to put in your application in if you’re interested! There’s a lot of interest and it’s shaping to be an exciting GRS+GRC.

Jordan Meier@doc-jlmeier.bsky.social · 2y ago

Applications for the 2025 Bioorganic GRC are now live! Here is the link where you can check out the current line-up: grc.org/bioorganic-c...

Reminder to join us (@fionachembot.bsky.social) for the Glycobiology GRS (and GRC!) in March. December 15 is the deadline for trainees (graduate students and postdocs) to submit abstracts to be considered for a talk at the GRS. #glycotime

Nick Riley@nmriley.bsky.social · 2y ago

Are you a trainee interested in glycobiology? Join us for the Glycobiology Gordon Research Seminar, March 22-23, 2025 in Italy! www.grc.org/glycobiology... We will have talks, posters, and a mentoring session with #glycotime leaders. Submit abstracts by Dec 15 to be considered for a talk!

Our paper about the development of programmable antigen-gated G-protein-coupled engineered receptors (PAGERs) is published today! www.nature.com/articles/s41... PAGERs couple detection of a wide range of custom-defined antigen to a variety of output including transgene expression and cell signaling.

Alice Ting@aliceyting.bsky.social · 2y ago

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

We are working on the program for the 5th Virtual ChemBioTalks on September 30th, 2025. While we already have commitments by our keynotes @oconnorlab.bsky.social and @craigmcrews.bsky.social, the remaining program is still in planning. Whom would you most like to hear at our next event?

The starter pack the TPD community has been waiting for: go.bsky.app/CE2P2Yh

Are you a trainee interested in glycobiology? Join us for the Glycobiology Gordon Research Seminar, March 22-23, 2025 in Italy! www.grc.org/glycobiology... We will have talks, posters, and a mentoring session with #glycotime leaders. Submit abstracts by Dec 15 to be considered for a talk!

Also wanted to highlight the Bioorganic GRC chaired by @doc-jlmeier.bsky.social and Denise! A great lineup and I cannot wait to be there!

Jordan Meier@doc-jlmeier.bsky.social · 2y ago

Applications for the 2025 Bioorganic GRC are now live! Here is the link where you can check out the current line-up: grc.org/bioorganic-c...

This is going to be an awesome weekend featuring great talks and interactions with the community. Hope to see you all in June 2025! 🙌

Jordan Meier@doc-jlmeier.bsky.social · 2y ago

Students and fellows should also check out the GRS, a stand-alone research seminar being organized by the amazing @ssmelyansky.bsky.social and Lindsey Lin: . grc.org/bioorganic-c... Shout out to my amazing co-organizer Denise Field (Pfizer). Hope to see many of you in NH in June!

Also fyi admission to the GRS does not guarantee admission to the GRC or vice versa! We are two standalone conferences, but we encourage trainees to apply to both if interested. If you have questions feel free to DM me!

If you are a trainee in chembio and looking for one conference to attend for 2025, you should apply for the bioorganic GRS that @ssmelyansky.bsky.social and I are putting together!

Stephanie Smelyansky@ssmelyansky.bsky.social · 2y ago

Come hang with me and @zhilindseylin.bsky.social at the 2025 Bioorganic Chemistry GRS! It’ll be a weekend full of excellent science and even more excellent people. The GRS is one of my favorite weekends of the year and we’re looking forward to another seminar full of amazing, trainee-led science!

Super useful tool to import list of people you were following on Twitter to 🦋

Itai Yanai@itaiyanai.bsky.social · 2y ago

If you're just coming in from Twitter, a great way to reconnect with your community is to find the people you were following there with the Sky Follower Bridge. It works really well! www.sky-follower-bridge.dev

Check out this comprehensive work led by Johannes @mo_hannes (soon-to-join Caltech 2025!) with @kevansf. Grateful to contribute to this great discovery targeting GTPases beyond K-Ras. Congratulations to the team! 🥳 https://t.co/4TBhFeI0ls