Christian Webb, PhD

@christianwebb.bsky.social

Associate Professor | Harvard Medical School Co-Director | Center for Depression, Anxiety, & Stress Research Director | Treatment & Etiology of Depression in Youth Lab | McLean Hospital | www.WebbsLab.com McGill & UPenn alum | Canadian in Boston

Photo from our recent lab dinner. Science is a team sport, and I feel incredibly fortunate to work with such an amazing group of colleagues and trainees. Beyond the papers and grants, it’s the people who make this work meaningful. Grateful for this team and excited for what’s ahead. Cheers! 🍻

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In addition to a hiring PhD in ~October & hopefully some PhDs and postdocs ~February, if anyone would like to work with me as part of eg a Marie-Curie or something similar, please do get in touch. Topics include depression, classification, measurement, systems, time-series, & theory building.

Looking forward to SPR 2026 in Osaka 🇯🇵 next week, where members of our lab will be participating in several sessions focused on AI-informed interventions, digital mental health, personalization, measurement, and psychotherapy process. If you’ll be at SPR, swing by and say hello! lnkd.in/gpcYJ3Pd

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I dug into NSDUH data on depression in U.S. teens (12-17) and made the below figure. Rates increased far more sharply for girls than boys, peaking around COVID before modest declines. Shaded region = % with depression receiving mental health treatment. Both depression and unmet need remain high.

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Honored to have been part of the Science of Change symposium at URI, celebrating the life and legacy of Dr. James Prochaska. I shared our work using AI and machine learning for real-time detection and scalable interventions in adolescent depression via smartphones and wearables.

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New paper from our team: Can ML identify which adolescents benefit most from school-based mindfulness? In 8,376 students (MYRIAD trial), models detected statistically significant but clinically negligible differential effects (d ≈ .07–.08). Precision prevention is hard...

JAMA Psychiatry@jamapsychiatry.com · 6mo ago

Machine learning analyses in the MYRIAD trial found only clinically trivial personalization of school-based mindfulness for adolescent #Depression prevention, underscoring limited differential benefit in universal programs. ja.ma/3OkeH2P

Two bar graphs compare changes in CES-D scores between SBMT and TAU interventions using a causal forest model and an elastic net regression model. The causal forest model shows a d=0.07, P=.007 for SBMT and d=-0.01, P=.82 for TAU.

Interesting to see how our lab's recruitment sources have shifted over the last 3 years (see plot). FB/Instagram used to pull 100+ responses/month, now much less productive. Methods like flyers and mailing lists remain steady. Curious if any other labs are seeing this or have found new methods?

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Matthew 25:40-45 “Then he will say to them... ‘Depart from me, you who are cursed, into the eternal fire prepared for the devil and his angels. For... I was a stranger and you did not invite me in, I needed clothes and you did not clothe me, I was sick and in prison and you did not look after me.’

Aaron Rupar@atrupar.com · 6mo ago

Q: Pope Leo cited Matthew 25:35 to critique Donald Trump's mass deportation agenda. How would you respond to Pope Leo in scripture? MIKE JOHNSON: Sovereign borders are biblical and right and just. It's not because we hate the people on the outside. It's because we love the people on the inside.