New Approach Opens Rare Immune Cells to Genetic Risk Research. Congratulations to the team! Learn more: scienceblog.cincinnatichildrens.org/new-approach...

Waggoner Lab@labwaggoner.bsky.social · yesterday

Excited this multi-year collaboration is in print @NatureGenet with @mspivakov.bsky.social @MalyValerie @HelenR_J Low-input Capture Hi-C reveals promoter-anchored chromosomal interactions in human ILC3 prioritzing CLN3 & other genes as potential ILC3-specific mediators of genetic risk for #IBD

Cincinnati Children's researchers developed an address-level model that links housing, crime, eviction, birth and neighborhood data to pediatric hospitalization risk, offering a more precise framework for place-based child health interventions. Learn more:

New Research Tool Maps Child Hospitalization Risk at the Address Level - Research Horizons

Cincinnati Children’s researchers developed an address-level model that links housing, crime, eviction, birth, and neighborhood data to pediatric hospitalization risk, offering a more precise framework for place-based child health interventions.

scienceblog.cincinnatichildrens.org

New @gohealio.bsky.social article featuring @cincychildrens.bsky.social researcher Timothy Dribin, MD. A model can predict which children who received an #epinephrine dose for #anaphylaxis before ED arrival are at risk for receiving it again after arrival using prehospital data.

Model identifies pediatric patients with anaphylaxis who may not need ED visit

A model can predict which children/adolescents who received an epinephrine dose for anaphylaxis before ED arrival are at risk for receiving it again after ED arrival using prehospital data, according ...

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Researchers at Cincinnati Children's developed the 5-item BRACHA-S tool to help identify youth most likely to become aggressive during emergency psychiatric visits. The tool may help staff prepare and address concerns before they escalate. Published The American Academy of Pediatrics.

Risky Agitation Can Be Predicted in Emergency Departments - Research Horizons

A new Cincinnati Children’s study shows BRACHA-S can help predict agitation risk in pediatric psychiatric emergency visits.

scienceblog.cincinnatichildrens.org

Congratulations to Daniel Starczynowski, PhD, who was appointed director of Cincinnati Children's Division of Experimental Hematology & Cancer Biology, scientific & innovation director of the Cancer & Blood Diseases Institute, and research director of University of Cincinnati's Cancer Center.

Daniel Starczynowski Appointed to Key Cancer Research Leadership Roles - Research Horizons

One of the nation's top leukemia researchers will guide Cincinnati Children's cancer and blood disease research and scientific collaboration with UC Cancer Center.

scienceblog.cincinnatichildrens.org

New research from Cincinnati Children's found that hospital-based mental health interventions can reduce anxiety, stress and depression among NICU parents. The review included 160 studies and more than 16,000 parents. Published in JAMA Pediatrics.

Parents Benefit from NICU Mental Health Support - Research Horizons

A Cincinnati Children’s-led study finds that NICU-based mental health support can reduce anxiety, stress and depression among parents, suggesting these services should become part of standard neonatal care.

scienceblog.cincinnatichildrens.org

A Cincinnati Children's led team and collaborators at Forge Biologics report that #genetherapy restored key #fragileX syndrome traits in mice. Study found improvements in seizure susceptibility, sensory hyperactivity and EEG biomarkers that could help bridge animal studies and future human trials.

Gene Therapy Restores Key Fragile X Traits in Preclinical Study - Research Horizons

Gene therapy restored key fragile X syndrome traits in mice, supporting future work on FMR1 replacement as a potential disease-modifying treatment.

scienceblog.cincinnatichildrens.org

A new multi-model study from Cincinnati Children's researchers found that targeted immune‑modulating therapies can outperform current anti-inflammatory treatment for TB meningitis. Published in Nature Communications. Read more: #Tuberculosis #InfectiousDiseases #GlobalHealth #Neurology

Study Points to New Strategy for TB Meningitis Care - Research Horizons

Multi-model study shows host-directed therapies reduce inflammation and outperform anti-inflammatory care in TB meningitis.

scienceblog.cincinnatichildrens.org

It is with heartfelt sadness that we share the passing of Susan Thompson, PhD, an internationally recognized leader in the Division of Rheumatology at Cincinnati Children's. For more than 30 years, she advanced the understanding of autoimmune diseases. Learn more about her legacy:

In Memoriam: Susan Thompson, PhD, 1958 – 2026 - Research Horizons

Learn about our Rheumatology division's first female faculty, whose research in juvenile arthritis helped shaped pediatric autoimmune research worldwide.

scienceblog.cincinnatichildrens.org

Maisam Abu-El-Haija, MD, MS, medical director, Pancreas Care Center, was named the recipient of the Caper: Collaborative Alliance for Pancreatic Education & Research Senior Mentor Award, the organization's highest distinction. Dr. Abu-El-Jaija delivers a featured lecture today at #PancreasFest26.

We're proud to support research that looks beyond the diagnosis. The BOND Trial will evaluate approaches to improve parent well-being, strengthen parent-infant bonding, and support healthy development for families navigating congenital heart disease. Learn more:

BOND Trial Aims to Improve Support for Families Facing Congenital Heart Disease - Research Horizons

Cincinnati Children’s researchers will help lead the BOND trial, a multicenter study testing ways to support parent well-being, breastfeeding and infant development after congenital heart disease diagnosis.

scienceblog.cincinnatichildrens.org

Researchers at Cincinnati Children's have produced one of the most comprehensive studies to date on how Epstein-Barr virus (EBV)—best known as the cause of mono—impacts human gene regulation. Published by Cell Press. Learn more about the findings: #Genomics #Immunology #AutoimmuneDisease

‘Mono’ Virus Found to Broadly Influence Human Genes - Research Horizons

Researchers map how Epstein-Barr virus interacts with human DNA, offering new insight into gene regulation and disease risk.

scienceblog.cincinnatichildrens.org

Great work by @philippdexheimer.bsky.social #Weiruach @cincyresearch.bsky.social @leeedsall.bsky.social Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genome www.cell.com/cell-genomic... #EBV genomics

Congrats to the research team at Cincinnati Children's CBDI and the UC Cancer Center as they collaborate to advance FLASH proton therapy! View blog post about the FAST-02 results: scienceblog.cincinnatichildrens.org/fast-02-clin... View study details: www.sciencedirect.com/science/arti...

Critically ill children are rarely seen in most emergency departments. A new Cincinnati Children's study published in Annals of Emergency Medicine found that regionalization alone isn't enough, highlighting the need for training and support across all care settings. Read more:

Limited Experience, High Stakes in Pediatric Emergency Care - Research Horizons

Study finds critically ill children are rarely seen in most EDs and few can be redirected, highlighting need for targeted pediatric readiness.

scienceblog.cincinnatichildrens.org

An important step forward in global health: researchers at Cincinnati Children's demonstrated 89% protection for a Shigella vaccine in a clinical trial. Published in The Lancet Infectious Diseases, these findings mark meaningful progress against a pathogen that infects millions.

Clinical Trial of Shigella Vaccine Shows 89% Protection - Research Horizons

A phase 2 clinical trial involving Cincinnati Children’s researchers found an oral Shigella vaccine candidate provided 89% protection, supporting further studies to combat a major global cause of diarrheal disease.

scienceblog.cincinnatichildrens.org

A large multicenter trial that included Cincinnati Children's finds that azithromycin does not improve preschool wheeze. Published in NEJM.org. Learn more about the study: #Pediatrics #ClinicalResearch #RespiratoryHealth

Large Trial Finds Azithromycin Fails to Improve Preschool Wheeze - Research Horizons

A large study finds antibiotics do not improve preschool wheezing, supporting evidence‑based care without routine antibiotic use.

scienceblog.cincinnatichildrens.org

A new phase 2 clinical trial published in @lancetgastrohep.bsky.social found that investigational dupilumab improved gastric eosinophil counts and histologic and endoscopic outcomes in people with eosinophilic gastritis (EoG). Learn more:

Dupilumab Improves Outcomes for EoG in Phase 2 Clinical Trial - Research Horizons

Phase 2 trial shows dupilumab improves key measures of disease activity in eosinophilic gastritis, a rare inflammatory stomach condition.

scienceblog.cincinnatichildrens.org

Why does #asthma severity vary so widely? Researchers at Cincinnati Children's have identified a role for MAIT cells in regulating allergic responses. Published in Allergy EAACI, the study highlights immune pathways beyond traditional inflammation. 🔬 Learn more: #AsthmaResearch #Immunology

Study Points to Immune Cell That Limits Asthma Severity - Research Horizons

Researchers show MAIT cells help control allergic responses in asthma, offering insight into differences in disease severity.

scienceblog.cincinnatichildrens.org

1/ New research from @cincychildrens.bsky.social's and collaborators found that 74% of children with recurrent or chronic pancreatitis carried at least one genetic risk variant. The study analyzed data from 944 children, the largest genotyped pediatric pancreatitis cohort to date.

Largest Pediatric Pancreatitis Genetics Study Identifies Risk Variants Tied to Disease Progression - Research Horizons

scienceblog.cincinnatichildrens.org

Research has shown that children with cancer have better outcomes when caregivers receive mental health support. Learn how Cincinnati Children's Caregiver Mental Health Program is making a difference for families like Taylor Fox's: #CancerResearch #CaregiverSupport #PediatricCancer #MentalHealth

Supporting Family Caregivers of Children and Young Adults with Cancer and Other Blood Diseases - Research Horizons

Cincinnati Children’s Caregiver Mental Health Program supports parents and loved ones of children and young adults with cancer and blood diseases through counseling, medication support and bereavement services.

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Curiosity can spark a career, but collaboration helps it grow. Kyle McCracken, MD, PhD, shares how Cincinnati Children's mentorship, teamwork and scientific culture shaped his path in kidney regenerative medicine. A look at what makes this a place where scientists thrive: #WeAreCincyKids

Road to Researcher: Kyle McCracken, MD, PhD - Research Horizons

The physician-scientist shares how an interest in kidney biology grew into a career in regenerative medicine and organoid research at Cincinnati Children’s.

scienceblog.cincinnatichildrens.org

We’re excited to announce that Cincinnati Children's has received a five-year grant of up to $17.25M from Aligning Research to Impact Autism (ARIA) to join the IMPACT Network as one of 12 global sites advancing autism research, clinical trial readiness, and more precise, individualized therapies.

$17.25 Million Grant to Advance Longitudinal Autism Research - Research Horizons

Cincinnati Children’s will receive up to $17.25 million to join a global autism research network aimed at improving trial readiness and accelerating new therapies for youth with autism.

scienceblog.cincinnatichildrens.org

How should healthcare systems respond when social needs complicate care and threaten outcomes? A recent article, co-led by Cincinnati Children's researchers, highlights how medical-legal partnerships help address housing instability and other health-harming legal needs in neonatal care. Learn more:

When Health Outcomes Depend on More Than Medicine - Research Horizons

Research shows how medical‑legal partnerships address legal and social needs during hospitalizations to support care and health outcomes.

scienceblog.cincinnatichildrens.org

The emotional and mental health needs of children and teens are rising—and so is the urgency for solutions. A Cincinnati Children's study shows how a coordinated primary care model reduced behavioral health ED visits by 25% and hospital admissions by a remarkable 58%. Learn more:

How Coordinated Primary Care Can Help Teens Avoid Hospital Stays for Behavioral Health Crises - Research Horizons

A Cincinnati Children’s teen primary care model reduced behavioral health emergency visits by 25% and hospital admissions by 58%, helping more teens get support before crises escalate.

scienceblog.cincinnatichildrens.org

Learn more about one of Cincinnati Children's 30 state‑of‑the‑art Shared Facilities, the Qualitative Methods & Analysis Collaborative (QMAC), in our latest Shared Facilities Spotlight. QMAC partners with internal and external researchers to support rigorous qualitative and mixed‑methods research.

Shared Facilities Spotlight: Qualitative Methods & Analysis Collaborative (QMAC) - Research Horizons

scienceblog.cincinnatichildrens.org

Join us in congratulating Mary Greiner, MD, MS, who has been named the next director of the Mayerson Center for Safe and Healthy Children, following a national search. A recognized leader in child abuse pediatrics and foster care health, Greiner brings deep experience in research, care and advocacy.

Mary Greiner Named Mayerson Center’s New Director - Research Horizons

Greiner, a nationally recognized leader in child abuse pediatrics and foster care health, will succeed Bob Shapiro after 42 years of service.

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Research led by Sonya Tang Girdwood, at Cincinnati Children's shows that higher cefepime exposure in critically ill children is linked to increased neurologic symptoms, informing safer care in the PICU. Read more on our Science Blog:

Why Antibiotic Exposure Matters in Pediatric Intensive Care - Research Horizons

Research links higher cefepime exposure to neurologic symptoms in critically ill children, highlighting challenges in dosing and monitoring.

scienceblog.cincinnatichildrens.org

Cincinnati Children’s researchers collaborate with colleagues in Uganda and beyond to help children where the disease burden is highest. Learn more on our Science Blog: @cincychildrens.bsky.social

10-Year Study Affirms Life-Changing Benefits of Hydroxyurea for Sickle Cell Anemia - Research Horizons

A 10-year study in Uganda shows hydroxyurea dramatically reduces complications and death from sickle cell anemia, offering hope for wider global treatment access.

scienceblog.cincinnatichildrens.org

NEJM.org@nejm.org · 2mo ago

Ugandan children with sickle cell anemia who received 10 years of hydroxyurea therapy had sustained laboratory and clinical benefits, improved growth, and few toxic effects. Read the full summary of research findings: https://nej.md/4nRSBlT

Promising news for Tourette syndrome research: a Phase III clinical trial led by researchers at Cincinnati Children's found that ecopipam reduced tics and lowered relapse risk in children. Findings published in JAMA Neurology. Learn more: #TouretteSyndrome #Neuroscience #PediatricResearch

New Med to Manage Tourette Syndrome Shows Promise in Phase III Clinical Trial - Research Horizons

Continued use of a drug called ecopipam can cut the risk of relapse in half for children battling tics caused by Tourette syndrome (TS).

scienceblog.cincinnatichildrens.org