Check out our lab's new manuscript entitled "Boolean Logic-Based Control Over Recombinant Protein Biomaterial Degradability and Therapeutic Delivery", now live in Advanced Materials! doi.org/10.1002/adma... Huge congrats to Murial, Ryan, and Shivani on this exciting story!

The publishing streak continues! Excited to share our new article in Nature Reviews Materials (@natrevmats.nature.com) entitled "Engineering Complexity into Protein-based Biomaterials for Biomedical Applications"! Check it out here: 📜: doi.org/10.1038/s415... 🔓: rdcu.be/eRFDh

Engineering complexity into protein-based biomaterials for biomedical applications - Nature Reviews Materials

Protein-based biomaterials are becoming increasingly prevalent in biomedical applications that treat and prevent disease. This Perspective examines the evolution of techniques used to build and design...

doi.org

Check out our new paper entitled "Boolean Logic-based Controlled Release of Bioactive Proteins with Diversified Inputs", live in @angewandtechemie.bsky.social ! Growth factors, enzymes, nanobodies, and cytokines can now be "logically" delivered! 📜: onlinelibrary.wiley.com/doi/10.1002/...

Medicine isn’t just about finding the right therapies — it’s also about getting them to where in the body they’re needed. These new smart proteins can autonomously read bodily cues to zero in on the exact locations of diseases. @coledeforest.bsky.social

Programmable proteins use logic to improve targeted drug delivery

Targeted drug delivery is a powerful and promising area of medicine. Therapies that pinpoint precise areas of the body can reduce the medicine dosage and avoid potentially harmful “off target”...

washington.edu

Our latest collaborative paper with David Baker's lab is now live in Cell Biomaterials (@cp-cellbiomat.bsky.social, Cell Press)! Check out "Stimuli-triggered Formation of De Novo-designed Protein Biomaterials"! 🔓 : www.cell.com/cell-biomate...

Our new paper entitled “Boolean Logic-gated Protein Presentation through Autonomously Compiled Molecular Topology” is now live at Nature Chemical Biology (@natchembio.nature.com)! Check it out! 📜: www.nature.com/articles/s41... @uwnews.uw.edu feature write-up: www.washington.edu/news/2025/10...

Cool science alert! A plasmid encoding a photodegradable hydrogel-forming protein called PhoCoil. Find it here: https://twp.ai/4iqKMK @coledeforest.bsky.social

New in @ScienceMagazine, we report that dilated cardiomyopathy can be alleviated by preventing hypocontractility-induced fibroblast expansion! The story is a fun combination of advanced in vivo and biomaterial-based in vitro models. Check it out! 📜 : doi.org/10.1126/scie...

Preventing hypocontractility-induced fibroblast expansion alleviates dilated cardiomyopathy

Cardiomyocyte hypocontractility underlies inherited dilated cardiomyopathy (DCM). Yet, whether fibroblasts modify DCM phenotypes remains unclear despite their regulation of fibrosis, which strongly pr...

doi.org

Our new manuscript entitled "PhoCoil: A Photodegradable and Injectable Single-component Recombinant Protein Hydrogel for Minimally Invasive Delivery and Degradation" is now live at @ScienceAdvances! Check it out here (🔓): www.science.org/doi/10.1126/...

PhoCoil: A photodegradable and injectable single-component recombinant protein hydrogel for minimally invasive delivery and degradation

PhoCoil is a genetically encoded hydrogel that enables noninvasive delivery and subsequent user-controlled photodegradation.

science.org

Check out our new paper entitled "Genetically Encoded Interpenetrating Polymer Networks as Injectable Biomaterials for Controlled Therapeutic Protein Delivery", appearing in ACS Biomat Science & Eng! pubs.acs.org/doi/10.1021/...

Genetically Encoded Interpenetrating Polymer Networks as Injectable Biomaterials for Controlled Therapeutic Protein Delivery

Though recombinant protein therapeutics hold great potential in treating many diseases, their intravenous delivery introduces challenges with off-target effects and short circulation half-lives. Injec...

pubs.acs.org

For the 2nd year in a row, one of our lab members has been selected for the prestigious Goldwater Scholarship. Huge congrats to Shivani Kottantharayil for her 2025 selection (and to Annabella Li for receiving the award last year)! UW press release is here: www.washington.edu/uaa/2025/04/...

Four UW undergraduates named 2025 Goldwater Scholars

Four University of Washington students have been named Goldwater Scholars by the Goldwater Foundation, advancing the University’s tradition of undergraduate academic excellence and...

washington.edu

In our latest manuscript, we demonstrate that grayscale control over local #biomaterial biochemistry and mechanics can be rapidly achieved across large constructs using an inexpensive (~$300) and commercially available LCD-based printer. Find it published in JBMR-A! doi.org/10.1002/jbm....

Rapid and Inexpensive Image‐Guided Grayscale Biomaterial Customization via LCD Printing

Grayscale control over local biomaterial biochemistry and mechanics can be rapidly achieved across large constructs using an inexpensive (~$300) and commercially available liquid crystal display (LCD....

doi.org

Happy Holidays from the DeForest Lab! What fun to celebrate the group’s 2024 achievements, especially in the baking sector. Our annual dessert bake-off competition was a tasty success!

The Anseth lab continues to pioneer many of the best and most versatile photoresponsive biomaterials known to our community. Congrats to @monicaohnsorg.bsky.social and Ella Hushka for summarizing the group's last 15 years of exciting efforts in their new paper!

Monica Ohnsorg, Ph.D.@monicaohnsorg.bsky.social · 2y ago

🌟 Perfect timing to check out our new @acspublications.bsky.social Accounts of Chemical Research article out online today summarizing the past 15 years of work with photoresponsive synthetic ECMs for biological applications conducted in the Anseth Lab! 🌟 #chemsky pubs.acs.org/doi/10.1021/...

Fun story from @matthewfainor.bsky.social on how next-gen recombinant proteins are being expressed in fruit flies, and what implications that could have for our lab-grown hydrogel biomaterials!

Matthew Fainor@handle.invalid · 2y ago

You're telling me the next generation of medical therapies will be made INSIDE fruit flies? But how? And why? fleshyfutures.substack.com/p/fruit-flie...

Professors often tell graduate students that “Your PhD is a #marathon, not a sprint”. Having now run the 2024 Seattle Marathon (many years after finishing a PhD), I now actually feel qualified to make such a statement. @uwmedicine.bsky.social

Introducing the Humanity Unlocking Biomaterials (HUB) national coordinating center. Opportunity to become involved with an incredible community, $100k research grants, core resources, and much more. Come join us! See more at our new website, here: www.humanityunlockingbiomaterials.org

HUB

humanityunlockingbiomaterials.org