The AI function in Up-to-Date just slowed me down. Do they test these things before release?

Excited to share an article that I've long awaited to share seeking to answer: What is the right dose of cephalexin/cefadroxil for SSTIs? We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social accpjournals.onlinelibrary.wiley.com/doi/10.1002/...

Getting It Right the Second Time: How Can we Optimize First‐Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies ...

accpjournals.onlinelibrary.wiley.com

If they get sick, best place in the world to be.

Jonathan Serrie@jonathanserrie.bsky.social · 3mo ago

The CDC says Americans on a cruise ship with a deadly hantavirus outbreak "are planned to be evacuated on a U.S. government medical repatriation flight to Offutt Air Force Base in Omaha, Nebraska, where they will be transported to the National Quarantine Center at the University of Nebraska, Omaha."

@jonathanrydermd.bsky.social: A CNS infection case is used as a framework for discussion of advanced CNS diagnostics, including diagnostic stewardship of multiplex PCR meningitis panels, plasma mcfDNA, and CSF mNGS.

Mindful diagnostics: a central nervous system infection case study | Antimicrobial Stewardship & Healthcare Epidemiology | Cambridge Core

Mindful diagnostics: a central nervous system infection case study - Volume 6 Issue 1

doi.org

A new summary of an old article from our group published in Journal of Infection (doi: 10.1016/j.jinf.2014.12.010) #sepsis #IDsky #infection

Officially open! Very honoured to be asked to cut the ribbon to unveil the new Haematology and Oncology ward at Heartlands Hospital in Birmingham. Thank you to every fan who bought a ticket for the guitar raffle, it really means a lot. Tony 🖤 Footage: BBC Midland News

🔥Just published🔥 SSC 2026 Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026 : Critical Care Medicine #IDsky #EMIMCC @pulmcrit.bsky.social share.google/NbagT9xMBTgk...

This is a great case for trainees to review, highlighting how to approach a complex patient who may not be responding to treatment as expected. The answer is not always "escalate antimicrobial therapy". #AMSSky doi.org/10.1093/cid/...

Changing Course

A 74-year-old man with end-stage renal disease (ESRD) on dialysis and cardiac sarcoidosis on chronic prednisone 20 mg daily presents to hospital with 2–3 w

doi.org

Another Reason to De-escalate. Check out this week’s KASIC pearl to learn about β-lactam/β-lactamase Inhibitors for MSSA kymdro.org/kasic/?p=8807 #IDsky #AntimicrobialResistance #antimicrobialstewardship #rxsky #pharmacy #FOAMed #NPs #PAs

Abundant

Clinical Infectious Diseases@cidjournal.bsky.social · 8mo ago

The Fate of Oral Meds ✅ Just Accepted 🔗 https://bit.ly/4qf88vX

Excited to share our latest publication about SEP-1 metrics during the BCx shortage in the setting of enhanced BCx stewardship efforts @kcawcutt.bsky.social @ichejournal.bsky.social #IDSky www.cambridge.org/core/journal...

In contrast to what ATS guidelines insist, antibiotics don't work for viral CAP... #IDSky

@id-journal.bsky.social · 8mo ago

In 6779 CAP patients with respiratory viruses, 0-2 vs 5-7 days antibiotics showed no diff in stay, ICU, mortality, or 30-day hospital-free days.🤒🦠 Antibiotics often unhelpful. #idsky

#idboardreview 5 wks post kidney transplant (deceased donor) pt had tremors, lower extremity weakness, confusion, urinary incontinence. 6 wks post transplant: fever, hydrophobia, dysphagia, autonomic instability & died 7wks postT #idsky #idmeded #meded

In the latest episode of The SHEA Podcast, Dr. Jonathan Ryder hosts a pro/con debate on procalcitonin with experts Dr. Michael Mansour and Dr. Sheetal Kandiah. They dig into where PCT adds value (or doesn’t) in antimicrobial stewardship and diagnostic decision-making. bit.ly/4pts2mW

It’s all in formalin?

Marjorie James Keenan@unenthusiast.com · 10mo ago

In honour of spooky month, share a 4 word horror story that only someone in your profession would understand. rm -rf ~/

Could re-title the article “The US could learn a lot from Nebraska”.

JAMA@jama.com · 11mo ago

As of the 2024-2025 academic year, 158 LCME-accredited medical schools operate within the US, reflecting a 26% growth over the last 20 years. #MedEd Read more about the program demographics: ja.ma/3IQGi9g

RIP Ozzie

a black and white drawing of a man pointing at the camera with the words happy birthday ross

ALT: a black and white drawing of a man pointing at the camera with the words happy birthday ross

media.tenor.com

Long C-19 is a plethora of pathways... No easy fix, because it's many routes to 🤬☠️ link.springer.com/article/10.1...

Advances in Understanding Long COVID: Pathophysiological Mechanisms and the Role of Omics Technologies in Biomarker Identification - Molecular Diagnosis & Therapy

Long coronavirus disease (COVID) is a multisystem condition that affects a significant proportion of individuals following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, with ...

link.springer.com

I bring here an old article from our group classifying the immunological alterations in sepsis into ten major immunophenotypes. Still useful in my view. #IDsky #immunoSky www.journalofinfection.com/article/S016... www.journalofinfection.com/article/S016...

Defining immunological dysfunction in sepsis: A requisite tool for precision medicine

Immunological dysregulation is now recognised as a major pathogenic event in sepsis. Stimulation of immune response and immuno-modulation are emerging approaches for the treatment of this disease. Def...

journalofinfection.com

#Elephants with jobs: Life guard

☝️A Bank of Sand Dollars !

Merriam-Webster@merriam-webster.com · last yr.

Q: Why are fish poorly educated? A: All the schools are below C level. Now that you've sat through that, please watch this video on animal collective names.

Ran into a colleague, he asked me how I was doing. I said with enthusiasm I was on my way to “make a sweet diagnosis”. He said “what, diabetes?” I had a quick laugh but I don’t think he heard a word I said after that because he couldn’t stop laughing for the rest of the time we talked. Good 4 him.

Thank you CDC for calling me back after hours on a Friday. You helped me provide world class care to a patient with a rare and difficult to treat infection. You are an absolute global treasure! #IDSky

I loaded an antibiogram into google sheets, data on over 100k isolates. Gemini, the AI assistant, offered, without me asking for it, if I wanted it to analyze the data. I thought sure why not, let’s see what it can do. I asked it a few simple questions and guess what? It’s terrible. #IDSky

Real-World HIV RNA And Antigen/Antibody Testing Among People Who Use Long-Acting Injectable PrEP - academic.oup.com/cid/advance-...

Real-world HIV RNA and antigen/antibody testing among people who use long-acting injectable PrEP

Among a real-world cohort of people who use long-acting injectable cabotegravir preexposure prophylaxis, no breakthrough infection was found. HIV RNA testi

academic.oup.com

I canceled Netflix.

Only now is it suggested that evidence based medicine be used as evidence in medical malpractice. There’s a lot of weak evidence out there and “custom” often masquerades as weak evidence. Hate to think someone has lost previously because “custom” trumped evidence.

JAMA@jama.com · last yr.

Most viewed in the last 7 days from JAMA: This Special Communication discusses the changes introduced in the first-ever restatement of the law of medical malpractice by the American Law Institute. https://ja.ma/41x7MWN

🆕 from Ilges et al: Real-word utility of procalcitonin (PCT) in patients hospitalized with community-acquired pneumonia: A matched cohort study ▶️ Authors find PCT testing not associated w/ reduced antimicrobial utilization, LOS, or 30-day all-cause mortality #IDSky 📄: doi.org/10.1017/ice....

www.dshs.texas.gov/news-alerts/...

There it is, mostly young, ~50% unvaccinated, 50% pending determination. www.dshs.texas.gov/news-alerts/...