Just published! The editorial in Chest with my good friend Profesor Toni Torres on eosinophil counts in community-acquired pneumonia is out! #IDsky #pneumonia Predicting Outcomes in Community-Acquired Pneumonia - CHEST journal.chestnet.org/article/S001...

The European Association of Urology guidelines recommend consideration of #UTI #vaccines. This vaccine has been available worldwide for over a decade. #IDSky #UTISky

Patrick Crowley@pcrowleydo.bsky.social · 2mo ago

News to me - there is an oral vaccine against UTIs. Anyone have experience with this? #IDSky #UTISky pmc.ncbi.nlm.nih.gov/articles/PMC...

Great to see our new paper out in Nature Communications. In it we describe three novel phenotypes in lungs of patients with pneumonia. Pn1 -a non-neutrophil driven lung injury phenotype, Pn2-a balanced immune response with best recovery and Pn3-persistent inflammation driven by immature neutrophils

Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes

Nature Communications - Analysis of cell samples from pneumonia patients may indicate specific phenotypes associated with disease. Here the authors use a multi-omics approach to analyse...

rdcu.be

Is oseltamivir killing ICU patients? The p-value for these results is NOT significant by traditional Frequentist benchmarks (p>0.05). But Bayesian statistics yield strongly positive results! Where does the truth lie? See what you think. Fresh blog: emcrit.org/pulmcrit/rem...

Remote monitoring of sepsis patients does not reduce hospital readmissions. Various at-home surveillance methods for patients with severe infections do not prevent them from returning to the hospital, a new study finds. Read more: ow.ly/6jNH50ZbjV1

Bundibugyo ebolavirus outbreak in the Democratic Republic of the Congo and Uganda: rapid assessment from the ESCMID Emerging Infections Subcommittee @cmijournal.bsky.social @escmid.bsky.social www.clinicalmicrobiologyandinfection.org/article/S119...

Bundibugyo ebolavirus outbreak in the Democratic Republic of the Congo and Uganda: rapid assessment from the ESCMID Emerging Infections Subcommittee

The ongoing outbreak of Ebola virus disease (EVD) caused by Bundibugyo ebolavirus (BDBV) in the Democratic Republic of the Congo (DRC) and Uganda represents a major regional public health emergency wi...

clinicalmicrobiologyandinfection.org

First reported case of Andes hantavirus cardiopulmonary syndrome treated with a combination of favipiravir, ribavirin, icatibant and baricitinib @cmijournal.bsky.social www.sciencedirect.com/science/arti...

The final version of our article evidencing that critically ill COVID-19 patients developing an early respiratory failure have live virus in the lung and high viral loads has been published today #IDsky www.sciencedirect.com/science/arti...

Poor control of pulmonary viral replication in COVID-19 patients with early respiratory failure

Severe respiratory failure is the leading cause of intensive care unit (ICU) admission and mortality in critically ill COVID-19 patients. However, whe…

sciencedirect.com

The Ebola outbreak brings to my mind this letter we published in Lancet Global Health proposing serum from vaccinated individuals as treatment (not appliable to the present epidemy since there is no vaccine yet, but some candidates are under research) #IDsky www.sciencedirect.com/science/arti...

Hyperimmune serum from healthy vaccinated individuals for Ebola virus disease?

sciencedirect.com

www.bbc.com/news/article...

How worrying is the Ebola outbreak in DR Congo?

An outbreak in DR Congo has been declared a health emergency, with almost 250 suspected cases reported.

bbc.com

La carga viral en la infección por el virus de los Andes es mayor que en otras infecciones por hantavirus. En esta infección existe una correlación inversa de la respuesta sérica de IgG específica con la carga viral y con la gravedad de la infección.

Estas son las conclusiones de este interesantísimo estudio publicado hace 11 años, y que podría tener utilidad clínica en el brote actual. onlinelibrary.wiley.com/doi/10.1002/...

¿Por qué los ancianos tuvieron una mayor mortalidad durante el primer año de la pandemia por COVID-19? En este articulo liderado por Tamara Postigo describimos signos de una respuesta antiviral deficiente, con activación de la coagulación y más daño endotelial. link.springer.com/article/10.1...

Key factors of the deranged antiviral response in elderly patients with COVID-19: a machine-learning analysis - GeroScience

Age is a well-known risk factor to develop severe viral respiratory infections, including severe COVID-19. This study aimed to identify the biological alterations linked to severe disease in elderly p...

link.springer.com

Why did the elderly suffer higher morbidity and mortality during the first year of the pandemic? This new multicenter study, coordinated by our group @BioSepsis, provides key insights. Congrats to Tamara Postigo for her leadership with this. link.springer.com/article/10.1...

Key factors of the deranged antiviral response in elderly patients with COVID-19: a machine-learning analysis - GeroScience

Age is a well-known risk factor to develop severe viral respiratory infections, including severe COVID-19. This study aimed to identify the biological alterations linked to severe disease in elderly p...

link.springer.com

Today I share a visual abstract of one of the articles I like the most from our group, deciphering key immunopathological events in severe pandemic influenza. This was a colaboration with my former boss, Dr. David Kelvin, and it was published in Critical Care in 2010: doi: 10.1186/cc9259 #IDsky

In this visual abstract of our article in In IJID we highlight the importance of of combining innate immunity and endothelial dysfunction biomarkers to predict increases in the magnitude of organ failure in patients with infection and sepsis (10.1016/j.ijid.2024.107142)

Another visual abstract of a previous work from our group evidencing the benefit of implementing programms to detect sepsis in preventing mortality derived from nosocomial sepsis (J Hosp Infec DOI: 10.1016/j.jhin.2017.08.022) #IDsky #sepsis

I share here the visual abstract of an important article from our group in colab with the groups of Dr Toni Torres (Hospital Clinic) and Rosario Menendez (Hosp La Fe) identifying Lymphopenic Community Acquired Pneumonia as a phenotype associated with mortality doi: 10.1016/j.ebiom.2017.09.023 #IDsky

This article from our group summarised the main immunological alterations in sepsis (Journal of Infection doi: 10.1016/j.jinf.2016.01.010) www.journalofinfection.com/article/S016...

A new summary of an old article from our group published in Journal of Infection (doi: 10.1016/j.jinf.2014.12.010) #sepsis #IDsky #infection

With the support of AI, I am starting to summarise some of our more important articles (summary 1: Quantification of Immune Dysregulation by Next-generation Polymerase Chain Reaction to Improve Sepsis Diagnosis in Surgical Patients", Annals of Surgery, DOI: 10.1097/SLA.0000000000002406)

In the pandemics, a mainstream theory proposed that in critical status, viral replication was over. Here we show that 60% of ventilated patients had replicative virus in the lungs, with 20% in high levels, mainly those with early resp. failure. #IDsky #COVID19 www.sciencedirect.com/science/arti...

Poor control of pulmonary viral replication in COVID-19 patients with early respiratory failure

Severe respiratory failure is the leading cause of intensive care unit (ICU) admission and mortality in critically ill COVID-19 patients. However, whe…

sciencedirect.com

Do critically ill COVID-19 patients still carry live virus in the lungs? In our new study we show that patients who develop rapid respiratory failure still have replicating virus. Important finding for guiding antivirals in future pandemics #IDsky #COVID19 www.sciencedirect.com/science/arti...

Poor control of pulmonary viral replication in COVID-19 patients with early respiratory failure

Severe respiratory failure is the leading cause of intensive care unit (ICU) admission and mortality in critically ill COVID-19 patients. However, whe…

sciencedirect.com

💥🆕“Sepsis”.The Lancet Seminar Our new article 👇Free Access bit.ly/4aJIiKo @unmc.bsky.social @unmc-id.bsky.social @unmccom.bsky.social @critcaremed.bsky.social @criticalcarereviews.com @thelancet.com @thelancetinfdis.bsky.social@lancetrespirmed.bsky.social#IDSky #MedSky #PCCSky #ICUSky #Ansky #EMSky

Sepsis

Sepsis is defined as a dysregulated host response to infection that leads to life-threatening organ dysfunction. The infectious insult triggers a dysr…

bit.ly

In immunocompromised patients, persistent COVID often fails single-drug treatment. Madrid study shows combination therapy (Remdesivir + Paxlovid ± Sotrovimab) clears infection and overcomes resistance. buff.ly/tqlmc0I Personalized antiviral strategies matter. #medsky #IDsky #publichealth #oncsky

A new paper from WHO-ISARIC that confirms lymphopenia as a marker of severity and poor prognosis in COVID-19, reinforcing our description of lymphopenic CAP (L-CAP) in 2017 In EbioMedine (I link our paper as a response to this one) link.springer.com/article/10.1...

Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients - Intensive Care Medicine Experimental

Objective Immune dysregulation plays a pivotal role in the pathophysiology of sepsis and COVID-19, with lymphopenia emerging as a consistent marker of severity and poor prognosis. However, most existi...

link.springer.com

This paper identifies transcriptomic signatures associated to mortality in sepsis similar to those we found ten years ago: neutrophil dysregulation + adaptive immunity depression, and evidences the relevance of combining host and microbial info. academic.oup.com/ajrccm/artic...

Host–Microbe Multiomic Profiling Predicts Mortality in Sepsis

Abstract. Rationale: Sepsis is a leading cause of mortality and involves a dysregulated host response to infection. The host and microbe have historically

academic.oup.com

Microbes Meet Host: The Next Frontier in Sepsis Classification @atscommunity.bsky.social #medsky 🔓 Open Access 🔗 tinyurl.com/bdes2e5s

Microbes Meet Host: The Next Frontier in Sepsis Classification

Our pathophysiological understanding of human disease fundamentally relies on our ability to make reproducible observations that demonstrate consistency an

tinyurl.com

After more than eight years serving as coordinator of the European Group on Immunology of Sepsis (EGIS) along with Prof. Ignacio Rubio, it is time for me to step back. The steering committee has designed Dr. Martin Winkler as my sucessor. I am sure he will do an excellent job. www.egis-online.eu

News are so terrible these days, that I need to concentrate in something constructive: let's do science, teach and cure people working together! In the world we are more people willing to improve things than those willing to destroy it...!