ComplexPortal
@complexportal.bsky.social
The Complex Portal is an encyclopaedic resource of macromolecular complexes from a number of key model organisms. http://www.ebi.ac.uk/complexportal Also follow➡️@intact-ebi.bsky.social
One example: the multi-aminoacyl-tRNA synthetase complex (MSC), CPX-2469 which streamlines tRNA charging and integrates regulatory signals. Its AIMP and ARS components go beyond translation, shaping immunity and cancer, with roles in tumour suppression and tumorigenesis. See tinyurl.com/38xvav39
tRNAs may be small, but they’re essential for turning genetic code into proteins -matching specific amino acids to corresponding codons on mRNA, tRNAs ensure that the genetic code is executed with precision.
🧬 Oncogenic KRAS mutations (pancreatic, colorectal, lung cancers) stabilize these complexes, sustaining growth signalling. Explore RAS at the complex level → new therapeutic insights. #RAS #KRAS #RASopathies #CancerBiology #ComplexPortal
🔬 𝑵𝒆𝒘! 𝐑𝐀𝐒 𝐬𝐢𝐠𝐧𝐚𝐥𝐥𝐢𝐧𝐠 𝐜𝐨𝐦𝐩𝐥𝐞𝐱𝐞𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐂𝐨𝐦𝐩𝐥𝐞𝐱 𝐏𝐨𝐫𝐭𝐚𝐥 RAS proteins function in multi-protein assemblies that drive MAPK & PI3K signalling.
🌍 Rare Disease Day: When Molecular Complexes Break Rare diseases aren’t just “gene disorders” - many disrupt macromolecular complexes, the molecular machines that keep cells running.
🔎 Exploring predicted complexes in the Complex Portal Beyond curated entries, the portal also includes computationally predicted protein complexes. Quick tour: tinyurl.com/2wph5wua Includes: 🧬 hu.MAP 3.0 🎵 MuSIC 🧪 QSProteome
🎉 Update from the Complex Portal! 🧬 The Complex Portal now links to QSProteome, a community-driven resource for predicted protein complex structures.
🎉 Complex Portal release 252 is out! 🎉 5,296 manually curated biological complexes are now live, in sync with UniProt 2026_01 🚀 Highlights by species: 🧬 Homo sapiens – 2,499 🌱 Arabidopsis thaliana – 228 🧫 Saccharomyces cerevisiae – 634 🧬 Schizosaccharomyces pombe – 145
Complex Portal release 252 is out! 5,296 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2026_01)
Are you working on challenging projects in structural biology? #EMBOMacromolecular will highlight the strategic use of cutting-edge protein structure prediction methods, and recent advances in in situ structural biology. Apply by 18 Feb to join us at EMBL Grenoble! 🧬 s.embl.org/mmo26-01-bl
🧬 New Year, new health goals - let’s get real: exercise fads, diets & oxygen therapies promise “blood cleansing,” but oxygen transport, circulation, cholesterol, and immune defence rely on real macromolecular complexes, not detox trends.
🌿 Why it matters • Excess NH₄⁺ disrupts growth and cellular balance • Species differ in ammonium tolerance, influencing biodiversity • Human-driven nitrogen favours ammonium-tolerant species 💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.
🌱 Balancing Act: Plants & Ammonium Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing. 💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
🌱 Balancing Act: Plants & Ammonium Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing. 💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
Registration is free but essential: tinyurl.com/4v3jf4e9 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Would you like to learn more about molecular interactions and how to explore them across organisms? Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology: “AI is showing how vital data curation really is.” www.ebi.ac.uk/about/news/p... 🖥️🧬
Sandra Orchard: what I’ve learned
EMBL-EBI Team Leader Sandra Orchard reflects on a life in protein science, UniProt data curation, and championing open data standards.
ebi.ac.uk
Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including: UniProt Complex Portal @complexportal.bsky.social Gene Ontology @geneontology.bsky.social IntAct @intact-ebi.bsky.social InterPro @interprodb.bsky.social
Follow the link to uncover: 🧩 what the complex does in the cell 🔄 pathways it participates in (Reactome) 🧬 and curated disease links (EFO, MONDO, OMIM). PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.
🔬 Noticed the new look PDBe? The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal! Example: PDB 6OOY → TNFA complex (CPX-8826).
🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin 🎨IntAct Cytoscape visualisation: Candida albicans ECE1 peptides (orange) and their human protein targets (blue) #IntActEBI #Interactome #EMBL
Don’t just publish - be found! 🔍 I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.
🧬 On #GlobalPNHAwarenessDay, we spotlight the GPI-GnT complex - a key enzyme disrupted in PNH, a rare and life-threatening blood disorder. 🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.
🕸️ Explore the interactome on the IntAct tinyurl.com/35922511. 🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details! #Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development. New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf 🔬 More info: tinyurl.com/47ed3er6
The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development. New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf 🔬 More info: tinyurl.com/47ed3er6
🧠 Today is #WorldAlzheimersDay. 📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression (tinyurl.com/37exu532). #WorldAlzheimersDay #AlzheimersSociety #Complexportal
