✨ New in IntAct✨ We’ve integrated the GPCR–RAMP interactome from Sakmar lab’s study 🧬🔬 🔗 www.ebi.ac.uk/intact/searc... 🔹 215 GPCRs tested 🔹 122 show strong RAMP interactions 🔹 23 endogenous GPCR–RAMP complexes identified 🔹 Fully curated dataset ready for analysis #GPCR #Interactome

👏 A big thanks to Élodie Monsellier @emonsellier.bsky.social and the team for their collaboration in bringing this integration to IntAct! #IntActEBI #PPI #NetworkBiology

🔬✨ New in 𝐈𝐧𝐭𝐀𝐜𝐭! Quantitative fragmentomics data (Nat Commun 2022) now integrated into IntAct - bringing high-quality, quantitative protein-protein interactions to the database.

👏 A big thanks to Élodie Monsellier @emonsellier.bsky.social and the team for their collaboration in bringing this integration to IntAct! #IntActEBI #PPI #NetworkBiology

🔬✨ New in 𝐈𝐧𝐭𝐀𝐜𝐭! 𝐐𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐟𝐫𝐚𝐠𝐦𝐞𝐧𝐭𝐨𝐦𝐢𝐜𝐬 𝐝𝐚𝐭𝐚 (Nat Commun 2022) now integrated into IntAct - bringing high-quality, quantitative protein-protein interactions to the database.

IntAct release 252 is out! 1,787,152 binary interactions from 23,889 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_04)

👏 Huge thanks to UniProt for integrating the isoform information! 🤝 This was a joint curation effort by IntAct and UniProt, and a great example of collaborative science. Here’s to an exciting year ahead! 🚀🧬 tinyurl.com/N-terminal-p... #EMBLEBI #IntActEBI #UniProt #Proteoforms

🎉✨ Happy 2026! ✨🎉 We’re excited to kick off the year by sharing the integration of the work “N-terminal proteoforms may engage in different protein complexes” from the Kris Gevaert lab (VIB, Ghent, Belgium) 🎓🔬

Registration is free but essential: tinyurl.com/4v3jf4e9 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

Would you like to learn more about molecular interactions and how to explore them across organisms? Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.

From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology: “AI is showing how vital data curation really is.” www.ebi.ac.uk/about/news/p... 🖥️🧬

Sandra Orchard: what I’ve learned

EMBL-EBI Team Leader Sandra Orchard reflects on a life in protein science, UniProt data curation, and championing open data standards.

ebi.ac.uk

Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including: UniProt Complex Portal @complexportal.bsky.social Gene Ontology @geneontology.bsky.social IntAct @intact-ebi.bsky.social InterPro @interprodb.bsky.social

Would you like to learn more about molecular interactions and how to explore them across organisms? Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.

🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin 🎨IntAct Cytoscape visualisation: Candida albicans ECE1 peptides (orange) and their human protein targets (blue) #IntActEBI #Interactome #EMBL

✨🧬New on IntAct! ✨ Interaction data from the study 📖“Global fungal–host interactome mapping identifies host targets of candidalysin” - Shanghai Jiao Tong University, Tongji University, and the Chinese Academy of Sciences. 🎉

Let’s make your science more FAIR - Findable, Accessible, Interoperable, and Reusable. #Biocuration #FromBenchToDatabase #FAIRdata #ProteinInteractions #EMBL-EBI #IntAct-EBI #OpenScience #UniProt #DataMatters

📥 Submit your data here: 🔹 IntAct: tinyurl.com/zzrcx742

Want your PPI or structural data to make an impact? ✅ Use Identifierss ✅ Include structured tables (e.g. Niri et al. 2021 - PMID: 34197713) ✅ Submit to EMBL-EBI's data resources - IntAct 👉 See Niri’s dataset in IntAct: tinyurl.com/yp8ddheh

Don’t just publish - be found! 🔍 I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.

🕸️ Explore the interactome on the IntAct tinyurl.com/35922511. 🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details! #Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem

🧬 “A physical wiring diagram for the human immune system” by the Wright Lab, University of York. 🔎 Study provides a systematic & quantitative view of the cell-surface proteins that enable immune cells to dynamically wire their interactions.

See also @wojtekgalej.bsky.social and tinyurl.com/3sfthabb #MinorSpliceosome #RNAsplicing #snRNP #U12Introns

The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development. New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf 🔬 More info: tinyurl.com/47ed3er6

PXD063858 🚨 Detection of TDP-43 - TAU interactions by XL-MS. 🚨 New dataset alert! 🚨

💜🧠 World Alzheimer’s Day 🧠💜 IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s. 🔗 Network: tinyurl.com/ynjwhy7y Paper: doi.org/10.3390/ijms24032490 #WorldAlzheimersDay #AlzheimersSociety

🧠 Today is #WorldAlzheimersDay. 📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression (tinyurl.com/37exu532). #WorldAlzheimersDay #AlzheimersSociety #Complexportal

💜🧠 World Alzheimer’s Day 🧠💜 IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s. 🔗 Network: tinyurl.com/ynjwhy7y Paper: doi.org/10.3390/ijms24032490 #WorldAlzheimersDay #AlzheimersSociety

💜🧠 World Alzheimer’s Day 🧠💜 IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s. 🔗 Network: tinyurl.com/ynjwhy7y Paper: doi.org/10.3390/ijms24032490

IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)

🧠 Alzheimer’s research meets precision medicine 📊 IMEx data from IntAct & Complex Portal 🧬 How AD mutations disrupt brain protein networks 🔍 Variant pathways, APP, miRNA 🚀 Toward targeted AD therapies 🔗 doi.org/10.1002/pmic... #KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety