Caroline Puente-Lelievre

@cpuentelelievre.bsky.social

Research fellow @aucklanduni.bsky.social Structural phylogenetics #strphylo protein evolution, plant systematics

Today’s #ISME20 plenary: Noah Fierer (Winogradsky Award) on moving from genomes to traits in Antarctic soils. Genomes alone are not enough to determine microbial traits, metabolism and environmental preferences, we need more isolate culturing to better understand microbial diversity and ecology.

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Some bacteria do not live as individuals. They build multicellular filaments and connect neighboring cells through tiny cell-cell junctions. Cyanobacteria are among the most beautiful examples 😍 In our new paper, we reveal first molecuar insights on the cyanobacterial septal junction architecture 🧵

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Japanese scientists have confirmed a monumental discovery: asteroid Ryugu contains all 5 nucleobases essential for DNA and RNA. By analyzing 5.4 grams of material returned by the Hayabusa2 spacecraft, researchers identified adenine, guanine, cytosine, thymine, and uracil in similar proportions.

source: Oba, Y., et al. (2026). A complete set of canonical nucleobases in the carbonaceous asteroid (162173) Ryugu. Nature Astronomy.

These are the results of the poll at the @geneticsaus.bsky.social conference. Will do a new one soon, with perilogs included this time. Have your say!

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Selene FeRNAndez@selfdz.bsky.social · 4mo ago

Hive mind - Carolina Puente-Lelievre (@cpuentelelievre.bsky.social) asks: How should we call homologs that are contained within the same protein? a. Plurilogs b. Polilogs c. Multilogs d. Perilogs Thoughts? Cool talk! #GSABrisbane26 @geneticsaus.bsky.social

First time at a GSA conference! Great to see the range of research being presented and connect with the community. Thank you @geneticsaus.bsky.social for the opportunity to present our work on the evolution of bacterial motility and structural phylogenetics.

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Genetics Society of AustralAsia@geneticsaus.bsky.social · 4mo ago

#GSA2026 will be kicking off very soon ✨ We are looking forward to an amazing line up of talks over the next week! Please post your conference updates & photos and tag @geneticsaus.bsky.social to have them reposted by the official GSA account🚨

A new tool for structural phylogenetics: Folddisco makes connecting structural conservation to evolutionary signal beyond the twilight zone of protein sequence similarity a tractable problem. #StrPhy

Martin Steinegger 🇺🇦@martinsteinegger.bsky.social · 5mo ago

Folddisco is now published @natbiotech.nature.com. It’s a fast motif search for similar 3D DISCOntinuous residues like catalytic sites or zinc fingers across the entire protein universe. 📄 www.nature.com/articles/s41... 💾 folddisco.foldseek.com​​​​​​​​​​​​​​​​ 🌐 https://search.foldseek.com/folddisco

A phylogeny-aware approach to detecting amino acid coevolution: PHACE. Instead of relying on sequence alignments only, it maps substitutions onto evolutionary trees and accounts for shared ancestry. A nice step toward more accurate models of protein evolution and structure.

Nurdan Kuru@nurdankuru.bsky.social · last yr.

Our new algorithm PHACE: Phylogeny-Aware Detection of Molecular Coevolution, by me and Ogün Adebali (@compgenomics.bsky.social), is now published in Molecular Biology and Evolution. Many thanks to @nehircanozdemir.bsky.social for the beautiful illustration of PHACE!

AlphaFold is moving beyond single proteins to predicting complexes. Millions of interactions with strong confidence. This kind of data will help uncover how protein interactions evolve, how new functions arise, and how complex biological systems are built over time. Exciting to see where this goes!

Martin Steinegger 🇺🇦@martinsteinegger.bsky.social · 8mo ago

AlphaFold database has entered the era of complexes. Together with NVIDIA, DeepMind and EBI, we use ColabFold, OpenFold and MMseqs2-GPU to predict ~31 million complexes (homo & hetro-dimers) resulting in 1.8 million high-quality predictions 📄 research.nvidia.com/labs/dbr/ass... 🌐 alphafold.ebi.ac.uk

APSPM brought together protein evolution research from across the globe. @jtrinidad13.bsky.social used structural homology to predict the function of uncharacterised eukaryotic proteins and revealed deep conservation hidden from sequence alone. Thank you for sharing your work with us! #StryPhy

Juan Manuel Trinidad Barnech@jtrinidad13.bsky.social · 9mo ago

Wrapping up an incredible final day at the APSPM meeting! Huge thanks to the organizers @cpuentelelievre.bsky.social @proteinmechanic.bsky.social Jordan Douglas and all the speakers for the brilliant talks and rich discussions. Beautiful Brisbane! #StrPhy #StrPhy26 #StructuralPhylogenetics

❗⏰ Please remember that the deadline for submitting your applications for abstracts and awards for SMBE 2026 ends today. Join us in Copenhagen from June 28 to July 2 for a fantastic meeting! #SMBE2026

Society for Molecular Biology and Evolution@official-smbe.bsky.social · 11mo ago

Abstract submission & Award applications for SMBE 2026 are now open! Submit your research and apply for SMBE awards via the submission portal. 📝 Read more & submit here: smbe2026.org/abstracts And symposium selection is now finalized! 👉 See all accepted symposia: smbe2026.org/programme #SMBE2026

Abstract submission & Award applications for SMBE 2026 are now open!