Colin Semple
@csemple.bsky.social
Genomics, bioinformatics; attempting to say useful things about cancer and evolution. Institute of Genetics and Cancer, University of Edinburgh https://institute-genetics-cancer.ed.ac.uk https://semplelab.com
Monumental new paper from a great collaboration full of exceptional humans! www.nature.com/articles/s41...
Genetic background sets the trajectory of experimental cancer evolution - Nature
Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...
nature.com
Nature research paper: Genetic background sets the trajectory of experimental cancer evolution go.nature.com/3RzmnjJ
Genetic background sets the trajectory of experimental cancer evolution - Nature
Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stages of cancer development.
go.nature.com
🧬NEW PAPER🧬 To what extent is cancer development deterministic? Does the germline genome affect that predictability? Find out in our #StrainDifferences paper @nature.com "Genetic background sets the trajectory of experimental cancer evolution" www.nature.com/articles/s41... 🧵[1/14]
Genetic background sets the trajectory of experimental cancer evolution - Nature
Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stage...
nature.com
Delighted to contribute to this seminal study of a critical oncogene! A long journey but worth it in the end :-) www.nature.com/articles/s41...
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling - Nature Genetics
Saturation genome editing of a cancer mutation hotspot in CTNNB1, the gene encoding β-catenin, reveals a gradient of effects of missense mutations on Wnt signaling.
nature.com
Come to Edinburgh to study genomics and human disease! We are recruiting to our 4 year PhD programme - closing date 11th January 2026 institute-genetics-cancer.ed.ac.uk/igc-graduate...
MRC four-year International PhD programme: Human Genetics, Genomics and Disease | IGC Graduate Research & Training | Institute of Genetics and Cancer
Applications now open.
institute-genetics-cancer.ed.ac.uk
New preprint from the lab! Profiling triple negative breast cancer samples over time, we looked at tumour genome responses to treatment. We reveal major roles for whole genome duplication (WGD) as these tumours evolve; with WGD seen in many pre-treatment samples, but also re-emerging at recurrence.
bioRxiv Genomics@biorxiv-genomic.bsky.social · 9mo agoFrequent Whole-Genome Duplication Events Drive the Genomic Evolution of Triple-Negative Breast Cancer During Neoadjuvant Chemotherapy https://www.biorxiv.org/content/10.1101/2025.11.17.688693v1
Looking for a new opportunity in computational genomics? Join our group @uoe-igc.bsky.social @edinburgh-uni.bsky.social Deadline September 1! elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
Lecturer in Computational Genomics
Establishing an innovative research line as Lecturer in Computational Genomics related to reproductive disorders and genomic medicine. This Lecturer post is full-time (35 hours per week); however, we ...
elxw.fa.em3.oraclecloud.com
New publication from the lab! www.nature.com/articles/s41...
Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer - Nature Communications
Tumour evolution and heterogeneity in high grade serous ovarian cancer (HGSOC) remains poorly characterised. Here, the authors investigate the genomic landscape of HGSOC and reveal two distinct evolut...
nature.com
tl;dr — this EO co-opts the language of open science to implement a system of political control wherein presidential appointees are given broad latitude to designate any number of reasonable scientific activities and inferences as scientific misconduct, and to penalize those involved accordingly.
Restoring Gold Standard Science
By the authority vested in me as President by the Constitution and the laws of the United States of America, including section 7301 of title 5, United
whitehouse.gov
Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social Building AI models or the data to train them? Core funding of >$130M a year for a faculty of ~30. www.nature.com/naturecareer... acrobat.adobe.com/id/urn:aaid:... pls RT!
New publication from the lab! We used a machine learning approach to predict chromatin loop dynamics during human spermatogenesis - and find these structures do not direct gene expression but may drive the positioning of recombination events bmcbiol.biomedcentral.com/articles/10....
CTCF-anchored chromatin loop dynamics during human meiosis - BMC Biology
Background During meiosis, the mammalian genome is organised within chromatin loops, which facilitate synapsis, crossing over and chromosome segregation, setting the stage for recombination events and...
bmcbiol.biomedcentral.com
Watching the US take a wrecking ball to science 💔 🤯 Reminder of the importance of doing science in the open. Put data, software, resources in public domain, where no single govt can erase them. This is our collective knowledge. Distributed data systems are essential. www.nature.com/articles/s41...
Genomic data sharing: you don’t know what you’ve got (till it’s gone) - Nature Reviews Genetics
Reflecting on the core values of early data sharing agreements, the Bermuda Principles and the Fort Lauderdale Agreement, Kathryn E. Holt and Michael Inouye emphasize the need to reaffirm our commitme...
nature.com
Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence
#postdoctoral traineeships in the Hide Lab in Alzheimer's disease omics and in cancer immunoediting. #Spatial #snSeq? Integration?#compBiol We grow people and celebrate diversity @harvardmed.bsky.social @bidmcreseach.bsky.social @bidmc-cancercenter.bsky.social learn more: shorturl.at/97TpL
Delighted to see this work emerge - exploiting a large in vivo mouse mutagenesis experiment to study evolutionary interactions between the nuclear and mitochondrial genomes during early tumourigenesis: bsky.app/profile/bior...
bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · last yr.Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis https://www.biorxiv.org/content/10.1101/2025.02.11.637769v1
Germline and somatic variation influence nuclear-mitochondrial crosstalk in tumourigenesis https://www.biorxiv.org/content/10.1101/2025.02.11.637769v1
American science is under attack Opinion piece by Dr Harold Varmus, Nobel Prize winner, former director of the #NIH and the #NCI 🧪 “Perhaps what’s most disheartening is what feels like the absence of widespread opposition to this unraveling” www.nytimes.com/2025/02/14/o...
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
nytimes.com
A new preprint from the lab! www.biorxiv.org/content/10.1...
Systematic identification of context-dependent gene-essentiality in Glioblastoma: The GBM-CoDE platform
Glioblastoma (GBM) is a heterogeneous and aggressive brain tumour that is invariably fatal despite maximal treatment. Genetic or transcriptomic ‘biomarkers’ could be used to stratify patients for trea...
biorxiv.org
Building on our discovery of #LesionSegregation, @mikespencerchapman.bsky.social and colleagues from @sangerinstitute.bsky.social find that some DNA lesions can persist in humans for months or years! "Prolonged persistence of mutagenic DNA lesions in somatic cells" www.nature.com/articles/s41...
Prolonged persistence of mutagenic DNA lesions in somatic cells - Nature
Persistent DNA lesions can occur throughout the human lifespan and can remain in the genome of affected cells for several years and generate a substantial proportion of the mutational burden.
nature.com
To what extent is cancer development deterministic and predictable..? Does the germline genome affect that predictability...? Preprint: www.biorxiv.org/content/10.1...
🌟NEW PREPRINT ALERT!🌟 We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution” www.biorxiv.org/content/10.1... 🧵[1/12]
Genetic background sets the trajectory of cancer evolution
Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...
biorxiv.org
We are hiring a new postdoctoral bioinformatician! Come and work with us on multidisciplinary cancer genomics projects at the Institute of Genetics and Cancer in Edinburgh: elxw.fa.em3.oraclecloud.com/hcmUI/Candid... institute-genetics-cancer.ed.ac.uk semplelab.com
The SIDB PhD programme with projects on neurodevelopmental disorders (including one from our lab) is now open for applications. Good stipend, excellent environment and a beautiful city sidb.org.uk/phds/
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits https://www.biorxiv.org/content/10.1101/2023.11.09.566307v1
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits https://www.biorxiv.org/content/10.1101/2023.11.09.566307v1
Abstract CTNNB1, the gene encoding beta-catenin, is a frequent target for oncogenic mutations activa
biorxiv.org
Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer https://www.biorxiv.org/content/10.1101/2024.01.12.575376v1
Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer https://www.biorxiv.org/content/10.1101/2024.01.12.575376v1
Deciphering the structural variation across tumour genomes is crucial to determine the events drivin
biorxiv.org
Protein structural context of cancer mutations reveals molecular mechanisms and identifies novel candidate driver genes https://www.biorxiv.org/content/10.1101/2024.03.21.586131v1
Protein structural context of cancer mutations reveals molecular mechanisms and identifies novel candidate driver genes https://www.biorxiv.org/content/10.1101/2024.03.21.586131v1
Advances in structure determination and computational modelling are enabling us to study the protein
biorxiv.org
How Musk broke Twitter and helped elect Trump (Location: Tesla European HQ, Amsterdam) www.youtube.com/watch?v=iX3v...
TESLA = TRUMP
YouTube video by Led By Donkeys
youtube.com
We are happy to announce the release of a new #nf-core workflow -- #oncoanalyser performs an exhaustive analysis of single-patient cancer sequencing data using methods developed by the Hartwig Medical Foundation Australia. (1/5)