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Daniel Croll

@danielcroll.bsky.social

We want to understand how pathogens adapt and cause diseases. Also passionate about TEs, pangenomes & population genomics, bioinformatics and conservation genomics. Professor of Evolutionary Genetics @ University of Neuchatel 🇨🇭 Hobbies: 👧🏻👧🏼🏔️🏕️

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Edel Pérez-López 🇨🇦@edelplopez.bsky.social · last mo.

The Genome Plasticity and Evolutionary Innovations session was absolutely outstanding! 🤯🧬 So many exciting ideas for new projects… at this rate, we might go from 25 to 50 people in the lab after #SMBE2026! 😅🫣 Incredible science, inspiring presentations, and an amazing lineup of researchers. 👏

Daniel Croll@danielcroll.bsky.social · 2mo ago

🔔 Our synthesis on what’s going on in the field of TE control and RIP in the fungal world! Out now in Trends in Genetics!

Thomas Badet@tbadet.bsky.social · 2mo ago

Nearly a year after our symposium on Repeat-Induced Point (RIP) mutations, I’m happy to share the fruit of some of our discussions. The fungal RIP hypermutator mechanism has deep eukaryotic roots www.sciencedirect.com/science/arti... We hope to spark interest in this underappreciated mechanism.

Evolution of major eukaryotic genome defense systems. The figure is organized along two axes representing core mechanistic features (homology recognition, small interfering RNA, and heterochromatin assembly) and their lineage-specific elaborations. We hypothesize that a recombination-independent DNA homology recognition system present in the eukaryotic common ancestor facilitated the emergence of both heterochromatin assembly and small RNA-based repeat silencing. From this conserved ancestral core, lineage-specific gene neofunctionalizations gave rise to distinct defense pathways: the RdDM pathway in plants; the piRNA and KRAB–ZFP pathways in vertebrates; and the repeat-induced point mutation (RIP), methylation induced premeiotically (MIP), MSUD, and tandem repeat-induced sexual silencing (TRISS) systems in filamentous ascomycete fungi. Question marks indicate steps for which the molecular mechanisms remain unknown.
Diana Gómez De La Cruz@dianagdlc.bsky.social · 2mo ago

So proud to see this story finally out!🎉 We added new data since our previous preprint—transgenic barley plants with an engineered immune receptor that fights off two fungal pathogens at once. Short 🧵 and link to the original preprint thread on X👇 www.science.org/doi/10.1126/...

Molecular mimicry of a pathogen virulence target by a plant immune receptor

Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...

science.org

Etienne Bucher 🌾🧬🇪🇺@plantepigenetics.ch · 2mo ago

We just published our new paper about an active Helitron transposon in wheat 🌾🧬 We found that it can be mobilised by heat stress when DNA methylation is reduced. We document its full lifecycle: RNA -> circular DNA -> integration www.nature.com/articles/s41... #TEsky

An active Helitron transposon family in wheat - Nature Plants

Helitrons are a recently identified category of transposons. This study reveals that heat stress combined with reduced DNA methylation can mobilize a Helitron family in wheat. Its mobilization is gene...

nature.com

Nature Microbiology@natmicrobiol.nature.com · 3mo ago

Out Now! Pooled CRISPRi screening reveals fungal-specific drug target candidates #MicroSky

Pooled CRISPRi screening reveals fungal-specific drug target candidates

Nature Microbiology, Published online: 11 May 2026; doi:10.1038/s41564-026-02356-wThis study presents a pooled CRISPRi screening approach in Candida albicans to investigate essential genes at scale, revealing environment- and strain-dependent gene sensitivities and conserved vulnerabilities relevant to antifungal drug discovery.

go.nature.com

Daniel Croll@danielcroll.bsky.social · 3mo ago

Genomepanel_nf v 1.0.8 is out! Includes a nice summary html in addition to the tsv files, more robust GATK implementation, even more aggressively saves on storage space and includes now a fully functional example dataset. crolllab.github.io/genomepanel_... Please get in touch if you have feedback.

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Daniel Croll@danielcroll.bsky.social · 4mo ago

Resequencing hundreds or thousands of individuals from the same species has become routine... but processing all those genomes efficiently? Still a headache! Here's my solution that used to be lab-internal but that I am happy to share: crolllab.github.io/genomepanel_...

Team Thomma@teamthomma.bsky.social · 3mo ago

Delighted to see this work out in #ScienceAdvancesResearch @science.org where we uncover a surprising evolutionary origin of fungal effector proteins as ancient antimicrobials. Led by the super-star @mesny.bsky.social in the frame of @ceplas.bsky.social @mibinet.bsky.social & @madfungi.bsky.social

Universität zu Köln@unicologne.bsky.social · 3mo ago

🍂🌱 An international research team led by @teamthomma.bsky.social has discovered the surprising evolutionary origin of fungal effector proteins: molecules that pathogens use today to infect their hosts appear to have evolved from ancient antimicrobial proteins. More: ➡️ uni.koeln/UCMWQ #UniCologne