A new study has identified a rare genetic condition which causes individuals to age at a faster rate than normal, shining a light on the mechanisms of aging. This study was jointly supervised by Kevin Myant, Elaine Dzierzak, Martin Reijns, @sproullab.bsky.social and Andrew Jackson edin.ac/4vDOCfM

Rare ageing disorder links ‘biological clock’ to disease | Institute of Genetics and Cancer | Institute of Genetics and Cancer

Scientists have discovered a rare genetic condition which causes people to age at a much faster rate, offering fresh insights into the ageing process.

edin.ac

What if DNA methylation changes aren’t just ticking of our biological clock but rather the rust breaking the gears? Very excited to share our work - how DNA methylation contributes to stem cell dysfunction and aging, published in @natgenet.nature.com doi.org/10.1038/s415... #epigenetics #aging 1/11

A progeria syndrome links DNA hypermethylation to age-related pathology - Nature Genetics

This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.

doi.org

We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.