Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Consumer neurotechnology is coming. We need to talk about it 👇

Protocol Labs@protocollabs.bsky.social · 3mo ago

1/ Neurotechnology is at a turning point. For decades, the focus has been clinical—restoring movement, speech, and mental health. That work is the foundation. People already spend $500B+ a year trying to control their brain states (relaxation, focus, sleep).

Super proud to have contributed to this amazing team effort, led by @sreejan.bsky.social and @botoscsabi.bsky.social! We asked: Which AI models learn to play video games like humans, comparing both behavior and internal representations. The answer surprised us! Check out our paper and post below

Botos Csabi@botoscsabi.bsky.social · 3mo ago

Jeee 🐦‍⬛ I am very proud of our joint effort with @sreejan.bsky.social on the project "Reason to Play" LRMs show human-like rule discovery, and their hidden states predict human brain activity during gameplay 10x better than previous methods Interactive demo + paper: botcs.github.io/reason-to-pl...

Out now on @biorxivpreprint.bsky.social, a study from our electron microscopy team exploring the connections between excitatory neurons in layers 2,3, and 5 of the mouse brain. 🔬 Check out the study: https://www.biorxiv.org/content/10.64898/2026.04.23.720412v1

In 1986, John White published "The Mind of a Worm," the first complete wiring diagram of any animal's brain. 7,000+ synapses in C. elegans, mapped by hand. This year he won the Wiley Prize in Biomedical Sciences. And he's donating his share to OpenWorm.

Important modeling work

Everton J Agnes@ejagnes.bsky.social · 4mo ago

New preprint with @sevberg.bsky.social! We map Hopfield-like binary networks onto spiking networks with dendrites … and it works! Same memory capacity, bigger basins of attraction, plus selective recall through dendritic gating, and more. How? Dendrites! See below.

1 year ago: "We developed and released tools for automated vulnerability detection. Look how we're using it to secure medical devices!" <everyone shrugs> Today: "Anthropic's new model automates vulnerability detection, but they are not releasing it because it's too dangerous." <everyone freaks out>

David A. Markowitz@davidamarkowitz.bsky.social · last yr.

🚨 There are 30M legacy medical devices in the US and 6.2 vulnerabilities per device. Our health infrastructure is NOT SECURE. To fix it, we need tools that automate vulnerability detection and remediation at scale. Today, my team is releasing those tools. 🧵

Excited to launch a new podcast on the future of neurotech, computing, intelligence, and more. First guest: @maxhodak.bsky.social founder & CEO of @science.xyz building PRIMA, a retinal prosthetic restoring meaningful vision for patients with AMD. www.youtube.com/watch?v=24CM...

Max Hodak — Restoring Sight, Growing Neurons on Silicon, and Expanding Human Intelligence

YouTube video by Juan Benet Podcast

youtube.com

What is holding #neurotech back from being one of the greatest breakthroughs of our time? Infrastructure. Getting from approval to access takes years — delaying patient access & company capital. PL Neuro aims to break these bottlenecks. Here's our Roadmap: zenodo.org/records/1924...

PL Neuro is officially live! plneuro.xyz We exist to break bottlenecks, accelerate progress in neurotech & NeuroAI, and to invest in innovations that benefit humanity. PL Neuro will focus on 3 core areas: - Neural augmentation - Biologically-inspired intelligence - Whole brain emulation

Homepage — PL Neuro

plneuro.xyz

1/ Neurotechnology is one of the defining opportunities of this century. We’re already seeing the potential to restore function, treat disease, and eventually expand human capability.

Preprint out arguing that we should build the techology to translate (compile) molecularly annotated connectomes into dynamics. I think this is incredibly important. arxiv.org/abs/2603.25713

Galen Buckwalter, a quadriplegic, received a brain implant in 2024 that is allowing him to create music with his thoughts. "It is so empowering to be able to do entirely unique things," he says. I spoke with Galen about the process and the importance of creativity: www.wired.com/story/meet-t...

Meet the Man Making Music With His Brain Implant

Galen Buckwalter says brain-computer interfaces will have to be enjoyable to use if the technology is going to be successful.

wired.com

Meet the Head of PL Neuro, @seanescola.bsky.social. In his new paper, he introduces the idea of “cognitive dark matter." A thoughtful framing of one of the biggest open questions in neuroscience. 👇

Sean Escola@seanescola.bsky.social · 5mo ago

We know about cosmological dark matter despite being unable to measure it because, without it, galaxies would fall apart. By analogy, let's talk about "cognitive dark matter" (CDM): brain functions that meaningfully shape behavior but are hard to infer from behavior alone. New paper! 🧵👇

Governor of Texas just ordered a statewide medical cybersecurity review based on my team's work for @arpa-h.bsky.social Fantastic real-world impact for patients! 👇 gov.texas.gov/uploads/file...

David A. Markowitz@davidamarkowitz.bsky.social · last yr.

🚨 There are 30M legacy medical devices in the US and 6.2 vulnerabilities per device. Our health infrastructure is NOT SECURE. To fix it, we need tools that automate vulnerability detection and remediation at scale. Today, my team is releasing those tools. 🧵

"Russian flu," the pandemic that hit in 1977, bears an evolutionary signature of having emerged from a lab, perhaps as part of a failed vaccine effort. Covid, mpox, Ebola, and other influenza pandemics don't. Here's my story on a new way to trace the origins of pandemics. Gift link: nyti.ms/46N0W33

Monitoring gene expression in the brain with a simple blood test? In collaboration with @jerzyszablowski.bsky.social & his lab we figured out how to do it nonhuman primates using noninvasive neuroengineering of synthetic serum markers. nam11.safelinks.protection.outlook.com?url=https%3A...

Connectomics is Method of the Year 2025!! @natmethods.nature.com just released the news nature.com/articles/s41... In my perspective piece, I afford some predictions into the future and compare how we are doing vs. genomics www.nature.com/articles/s41...

1 year later and wow, exciting to see big things in the works!!!

David A. Markowitz@davidamarkowitz.bsky.social · 2y ago

I'm calling for a $1B-scale effort to transform our understanding of intelligence as profoundly as astronomical observatories transformed our understanding of the cosmos. We need a new kind of institution focused on scale, impact and financial sustainability. More here 2/14 bsky.app/profile/thet...

Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41... This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)

Lots of excitement around open source computational binder design (BoltzGen FTW!), but as far as I can tell it's still ~2x more expensive per target than a traditional campaign with a CRO. (60k runs/target) x (2 mins/run) x ($5/hr for an A100) = $10k/target vs ~$5k with a CRO

I will be co-teaching a summer course at Allen Institute on connectomics education please apply. Travel support, new connectomics data sets and learning directly from the scientists who built these datasets. Details here: alleninstitute.org/events/incor...

Incorporating open connectomics data into teaching neuroscience

Learn to analyze open neuroscience data and introduce dry lab modules into your existing classes at the Incorporating Open Connectomics data into...

alleninstitute.org

I am super happy to share that our project on training biophysical models with Jaxley is now published in Nature Methods: www.nature.com/articles/s41...

Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods

Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...

nature.com

It's increasingly tempting to believe frontier models truly understand concepts and their relationships like humans do. Then I get a figure like this from today's leading model and the illusion is ruined. <sigh>

Is there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!

Sam Rodriques@sgrodriques.bsky.social · 9mo ago

Today, we're announcing Kosmos, our newest AI Scientist, available today. Kosmos makes fully autonomous scientific discoveries at scale by analyzing datasets and literature, and is the most powerful agent for science so far. Beta users estimate that Kosmos does 6 months of work in a single day.

For a decade, my white whale as a neuroscientist has been working to convince public+private funders to "go big" on post-mortem human tissue analysis, so we can define circuit disruptions in disease and just maybe link them with molecular drivers. This remains as tough a sell today as 10 years ago.

Today, we're announcing Kosmos, our newest AI Scientist, available today. Kosmos makes fully autonomous scientific discoveries at scale by analyzing datasets and literature, and is the most powerful agent for science so far. Beta users estimate that Kosmos does 6 months of work in a single day.

Very excited that the clinical trial results for our PRIMA retinal prosthesis are published today in the New England Journal of Medicine! This is the first time that patients who are blind due to photoreceptor loss have been able to intuitively see again. www.youtube.com/watch?v=J_qT...

A global mission to restore vision | PRIMA by Science

YouTube video by Science

youtube.com