Very much enjoyed this preprint - getting closer to a quantitative understanding on how promoter/enhancer interactions drive transcriptional activity: www.biorxiv.org/content/10.6...
biorxiv.org
David Suter
@davidsuter.bsky.social
PI at EPFL / gene regulation / chromatin / epigenetics / genomics / stem cells / transcription factors / single molecule / protein turnover https://www.epfl.ch/labs/suter-lab/ - and 🎹 https://www.youtube.com/@davidsuter594 / https://soundcloud.com/suterd7
What a tour-de-force ! Makes me think that the mechanisms enhancer-mediated transcriptional activation are now truly falling into place
Anders Sejr Hansen@andersshansen.bsky.social · last mo.(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...
Non-science post: join us in beautiful Cully for the Lavaux Festival www.lavauxclassic.ch ! I will play along with many other laureates of the Lavaux piano competition - concert will take place outside on the lake shore, free entrance, three hours of music, Saturday June 20, 13:00 to 16:00 🎹 🎶
Epigenetics means different things for different people. In this workshop we will discuss two major views anchored on transcriptional memory: chromatin vs networks. Come and share with us our excitement for the topic and the magnificent place, the Andalusian Baeza. urldefense.com/v3/__https:/...
Workshop Transcriptional memory in health and disease
The idea that cells remember past states to prepare their future endeavors has split into two parallel languages that rarely converse. On one side, chromatin epigenetics defines inheritance through th...
urldefense.com
"The Case for a Validity Layer in Life Science Research" - a very interesting article by Meir Maor, QED's CTO. Meir explains why biology is harder for AI than mathematics. www.qedscience.com/blog/life-sc...
The case for a validity layer in life science research
When OpenAI recently announced that one of its models had disproved a long-standing conjecture in discrete geometry, the scientific community took notice...
qedscience.com
Postdoc position available now in the Smith Group lsi.exeter.ac.uk/groups/smith... to test the hypothesis that differentiation biases between human pluripotent stem cell lines may be eliminated by reversion to the naïve state. careers.exeter.ac.uk/vacancies/79...
Smith Group - Living Systems Institute - University of Exeter
Understanding pluripotency
lsi.exeter.ac.uk
Not only at MIT...
Vicky C Yang@vcyang.bsky.social · 2mo agoBetween 1985--2023, MIT's faculty grew 9%. Administrative staff grew 189%. 📈 Why? In new @pnas.org paper, we use dynamical system model to show administrative bloat can emerge without empire-building--just from well-intentioned problem-solving gone awry www.pnas.org/doi/10.1073/...
Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!
📢 New preprint alert ! www.biorxiv.org/content/10.6... Joanna Dembska developed a highly scalable image-base screening platform for protein turnover modulators in human neurons, based on our fluorescent timer system. Protein turnover is perturbed in nearly all neurodegenerative diseases ...
biorxiv.org
Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity
The requirements for supplying source data for Nature journal family papers is out of control.
Very nice work on histone modifications of mitotic chromosomes ! And also points at issues working with nocodazole-mediated synchronization, which still so many labs use - this work here shows how it artificially results in loss of mitotic histone acetylation. www.cell.com/molecular-ce...
cell.com
Join us at the LS2 #Theory #across #Biology chalk talk symposium! 12 June 2026 in Bern, CH. @lifesciswitzerland.bsky.social No movies that fail, no Mac to PC issues. Only the best ideas and exchange across biology from evolution and ecology to physics of life. meetings.ls2.ch/theory-acros...
Monthly median Received to Accepted time (days) at Nature Genetics
Do we grow wiser as we age? I spent 15+ years chasing glam journals, wasting time and energy (and frustrating my team and co-authors). I don’t want to wake up at 70 and realize my life went into convincing a few editors my work was trendy enough. Enough. I’ll try to be smarter.
Non-science post - Any plans for Easter ? If not, come join us in Evian 🇫🇷 on 4.4. for the piano marathon ! My menu: Brahms : Rhapsodie op.79 n°1, Schumann : 2 pieces from Fantaisiestücke op. 12, Chopin : Ballade n°4 & Mazurka op.59 n°2 info 👇 marathondupiano.com www.youtube.com/watch?v=ya7M...
Teaser - Concert Evian
YouTube video by David Suter
youtube.com
Email spam in 2026 is so out of control that it feels like smashing nagging mosquitoes on a hot summer night
Very interesting work from on the role of IDRs in DNA binding specificity - in the cases studied here, the DBD plays almost no role 😮. www.science.org/doi/epdf/10....
science.org
TFs search are governed by many parameters, what about electrostatic forces? @simsakong.bsky.social led a multi-scale study on Sox2 revealing how electrostatic interactions influence its search. In close collaboration with @davidsuter.bsky.social. Congratulations Sim 🎉 www.nature.com/articles/s41...
Electrostatic properties of disordered regions control transcription factor search and pioneer activity - Nature Communications
This work describes how positive charge in the peptide chain flanking the DNA-binding domain of transcription factors speeds up their search on free and chromatinized DNA, helping to explain why some ...
nature.com
How do electrostatic forces impact TF search ? In joint effort with @beatfierz.bsky.social , tour-de-force from @simsakong.bsky.social who single-handedly combined in vitro SPT on DNA & chromatin, in cellulo SPT, ChIP-seq and ATAC-seq www.nature.com/articles/s41...
Electrostatic properties of disordered regions control transcription factor search and pioneer activity - Nature Communications
This work describes how positive charge in the peptide chain flanking the DNA-binding domain of transcription factors speeds up their search on free and chromatinized DNA, helping to explain why some ...
nature.com
Waou ! Fabulous documentary, so much deserved !
The Tennessee Holler @thetnholler.bsky.social · 5mo ago‘Mr. Nobody Against Putin’ Director: “This is about how you lose your country — through small acts of complicity: when a government murders people on the streets, when oligarchs take over the media… we all face a moral choice. But even a nobody is more powerful than you think."
How do the H2A.Z histone variant and its dedicated chromatin remodeller SRCAP regulate gene expression ? Beautiful work from @armelletollenaere.bsky.social now published @ www.nature.com/articles/s41...
Mechanisms of gene regulation by SRCAP and H2A.Z - Nature Communications
SRCAP depletion causes rapid replacement of H2A.Z by H2A, leading to upregulation of lineage-specific transcription factors. SRCAP also prevents pioneer transcription factor binding by steric hindranc...
nature.com
You are finishing your PhD and looking to continue in science? The Martin lab @biology-unige.bsky.social has an open postdoctoral position in cell biology to study cell-cell fusion. For more information, please consult mocel.unige.ch/research-gro.... Thanks for reposting!
Contact/Job - Department of Molecular and Cellular Biology - UNIGE
mocel.unige.ch
