#Music teacher, conductor & composer Nadia Boulanger is regarded as the most influential music pedagogue of the 20th century. Shattered glass ceilings by becoming the first woman to conduct the Boston Symphony Orchestra, NY Philharmonic & the Royal Philharmonic Society in London. #MusicSky🧵

Sounds very exciting - for sure my own ignorance, but I cannot help being surprised that in some fields, N=1 --> big splash. In mine, N=1 --> ...most likely an artifact.

Michael Greshko@michaelgreshko.bsky.social · 3w ago

BREAKING: The world's most sensitive dark matter detector has announced it has spotted something it can't easily explain: a single event that's tantalizingly consistent with a type of theorized dark matter particle. Very early days yet, but pretty wild. 🧪 www.science.org/content/arti...

Remember this? bsky.app/profile/did:... Rigorous visualization of the structure in your high-dimensional data. Fantastic work by @dhdegroot.bsky.social With help of the reviewers of Nat Biotech it is now updated, extended an officially published here: www.nature.com/articles/s41... 1/n

Bonsai reconstructs tree representations for distortion-free visualization and exploration of high-dimensional data - Nature Biotechnology

High-dimensional data are visualized through representation on tree structures.

nature.com

Erik van Nimwegen@erikvannimwegen.bsky.social · last yr.

Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...

New paper from the lab! authors.elsevier.com/sd/article/S... We find that protein degradation is broadly slower in human segmentation clock cells than in mouse cells, regardless of the degradation pathway or protein category! 1/

Systematic differences in protein stability underlie species-specific developmental tempo

Human embryonic development proceeds more slowly than in mice. The segmentation clock offers a tractable model for studying species-specific developme…

authors.elsevier.com

Very much enjoyed this preprint - getting closer to a quantitative understanding on how promoter/enhancer interactions drive transcriptional activity: www.biorxiv.org/content/10.6...

What a tour-de-force ! Makes me think that the mechanisms enhancer-mediated transcriptional activation are now truly falling into place

Anders Sejr Hansen@andersshansen.bsky.social · 3mo ago

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

Q.E.D. 🤦‍♀️🇨🇭🤦‍♂️

Non-science post: join us in beautiful Cully for the Lavaux Festival www.lavauxclassic.ch ! I will play along with many other laureates of the Lavaux piano competition - concert will take place outside on the lake shore, free entrance, three hours of music, Saturday June 20, 13:00 to 16:00 🎹 🎶

Epigenetics means different things for different people. In this workshop we will discuss two major views anchored on transcriptional memory: chromatin vs networks. Come and share with us our excitement for the topic and the magnificent place, the Andalusian Baeza. urldefense.com/v3/__https:/...

Workshop Transcriptional memory in health and disease

The idea that cells remember past states to prepare their future endeavors has split into two parallel languages that rarely converse. On one side, chromatin epigenetics defines inheritance through th...

urldefense.com

"The Case for a Validity Layer in Life Science Research" - a very interesting article by Meir Maor, QED's CTO. Meir explains why biology is harder for AI than mathematics. www.qedscience.com/blog/life-sc...

The case for a validity layer in life science research

When OpenAI recently announced that one of its models had disproved a long-standing conjecture in discrete geometry, the scientific community took notice...

qedscience.com

Postdoc position available now in the Smith Group lsi.exeter.ac.uk/groups/smith... to test the hypothesis that differentiation biases between human pluripotent stem cell lines may be eliminated by reversion to the naïve state. careers.exeter.ac.uk/vacancies/79...

Not only at MIT...

Vicky C Yang@vcyang.bsky.social · 4mo ago

Between 1985--2023, MIT's faculty grew 9%. Administrative staff grew 189%. 📈 Why? In new @pnas.org paper, we use dynamical system model to show administrative bloat can emerge without empire-building--just from well-intentioned problem-solving gone awry www.pnas.org/doi/10.1073/...

Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!

📢 New preprint alert ! www.biorxiv.org/content/10.6... Joanna Dembska developed a highly scalable image-base screening platform for protein turnover modulators in human neurons, based on our fluorescent timer system. Protein turnover is perturbed in nearly all neurodegenerative diseases ...

Hello all, our lab is recruiting a PhD candidate to study how 3D genome folding impacts gene regulation in development. We're located at the Center for Integrative Genomics department of the University of Lausanne, Switzerland. Please email me if interested. #PhDPosition, #PhDOpportunity

This thread is brilliant

Charlotte Clymer@charlotteclymer.bsky.social · 5mo ago

I realize this is obvious to most but allow me to rant: At the core of Trump's base love for him is a simmering resentment over their mediocrity and gratitude for him making it permissible to be arrogant whilst mediocre. Everything in this cult can be traced back to that. (thread)

Some useful public speaking tips from Freud here.

Very nice work on histone modifications of mitotic chromosomes ! And also points at issues working with nocodazole-mediated synchronization, which still so many labs use - this work here shows how it artificially results in loss of mitotic histone acetylation. www.cell.com/molecular-ce...

Join us at the LS2 #Theory #across #Biology chalk talk symposium! 12 June 2026 in Bern, CH. @lifesciswitzerland.bsky.social No movies that fail, no Mac to PC issues. Only the best ideas and exchange across biology from evolution and ecology to physics of life. meetings.ls2.ch/theory-acros...

Monthly median Received to Accepted time (days) at Nature Genetics

Do we grow wiser as we age? I spent 15+ years chasing glam journals, wasting time and energy (and frustrating my team and co-authors). I don’t want to wake up at 70 and realize my life went into convincing a few editors my work was trendy enough. Enough. I’ll try to be smarter.

Non-science post - Any plans for Easter ? If not, come join us in Evian 🇫🇷 on 4.4. for the piano marathon ! My menu: Brahms : Rhapsodie op.79 n°1, Schumann : 2 pieces from Fantaisiestücke op. 12, Chopin : Ballade n°4 & Mazurka op.59 n°2 info 👇 marathondupiano.com www.youtube.com/watch?v=ya7M...

Teaser - Concert Evian

YouTube video by David Suter

youtube.com

Email spam in 2026 is so out of control that it feels like smashing nagging mosquitoes on a hot summer night

Demons - Dostoïevski

K.W. Colyard@kristianwriting.bsky.social · 6mo ago

So what was everyone's book they read way too young?

Very interesting work from on the role of IDRs in DNA binding specificity - in the cases studied here, the DBD plays almost no role 😮. www.science.org/doi/epdf/10....

TFs search are governed by many parameters, what about electrostatic forces? @simsakong.bsky.social led a multi-scale study on Sox2 revealing how electrostatic interactions influence its search. In close collaboration with @davidsuter.bsky.social. Congratulations Sim 🎉 www.nature.com/articles/s41...

Electrostatic properties of disordered regions control transcription factor search and pioneer activity - Nature Communications

This work describes how positive charge in the peptide chain flanking the DNA-binding domain of transcription factors speeds up their search on free and chromatinized DNA, helping to explain why some ...

nature.com

How do electrostatic forces impact TF search ? In joint effort with @beatfierz.bsky.social , tour-de-force from @simsakong.bsky.social who single-handedly combined in vitro SPT on DNA & chromatin, in cellulo SPT, ChIP-seq and ATAC-seq www.nature.com/articles/s41...

Electrostatic properties of disordered regions control transcription factor search and pioneer activity - Nature Communications

This work describes how positive charge in the peptide chain flanking the DNA-binding domain of transcription factors speeds up their search on free and chromatinized DNA, helping to explain why some ...

nature.com

Waou ! Fabulous documentary, so much deserved !

The Tennessee Holler @thetnholler.bsky.social · 6mo ago

‘Mr. Nobody Against Putin’ Director: “This is about how you lose your country — through small acts of complicity: when a government murders people on the streets, when oligarchs take over the media… we all face a moral choice. But even a nobody is more powerful than you think."