I’m excited to share that my PhD work is now published in @natcomms.nature.com! Big thanks to @davidsuter.bsky.social & @beatfierz.bsky.social for your guidance throughout this work. We show that electrostatic differences in disordered regions control TF search and chromatin invasion. More details👇

David Suter@davidsuter.bsky.social · 5mo ago

How do electrostatic forces impact TF search ? In joint effort with @beatfierz.bsky.social , tour-de-force from @simsakong.bsky.social who single-handedly combined in vitro SPT on DNA & chromatin, in cellulo SPT, ChIP-seq and ATAC-seq www.nature.com/articles/s41...

The work of Xingyu Liu @xingyuliu9595.bsky.social in collaboration with Wei Cai in Beat Fierz @beatfierz.bsky.social group @lcbm-epfl.bsky.social and Anne-Sophie Chauvin on peptide-cyanoarenes used as photocatalysts is now accepted in @angewandtechemie.bsky.social ! doi.org/10.1002/anie...

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established. www.science.org/doi/10.1126/...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.

science.org

I am very happy to share that I was awarded a PhD fellowship from the Boehringer Ingelheim Fonds (BIF) for my project about nucleosome depletion in @lcbm-epfl.bsky.social with @beatfierz.bsky.social. Looking forward to joining the BIF community 😊🥳

#SIRT7 is a histone deacetylase with highly specific activity on #chromatin substrates. We just published mechanism-based #cryoEM structures of #SIRT7 on nucleosomes to understand its activity 👇 www.nature.com/articles/s41... (1/8) #ChemBio #ChemSky

Don’t miss tomorrow's in-person #chembio seminar by Prof. Dr. Nina Hartrampf @ninahartrampf.bsky.social 👉 "New Methods for the Chemical Synthesis of Post-Translationally Modified Peptides and Proteins" ⏱️🇨🇭16:15 › 17:15 📢 bit.ly/3MOjVjy

Chemical Biology Seminar Series 3 (CH-637)

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bit.ly

Always nice to share the ideas together! Many THX to who show interest and ideas in our project 🙏 If interested in TF target search, feel free to contact us 📧 @beatfierz.bsky.social @davidsuter.bsky.social THX to the EMBL travel grant for me to attend such great conference #EMBLOmics

🎖️ Yesterday PhD #Benjamin won a presentation price at the LS2 sub-section meeting – nice recognition for his careful #DyeCycling work! 🟢🔴🧬 Many thanks to @beatfierz.bsky.social, #KatjaOdening & all for organizing! Also great to meet the 🇨🇭 community, #SimonScheuring, #ChanCao, #WayneYang ...👌

Are you looking for a PhD position in peptide synthesis, automation, and computational analysis? 🧪 💊💻 We have an open position for a collaborative PhD thesis (with Novo Nordisk). For more details, please see: jobs.uzh.ch/job-vacancie... ⏰ Application deadline = November 15

UZH: PhD Position in Solid-Phase Peptide Synthesis (Industry Collaboration)

A PhD position is available in the group of Prof. Dr. Nina Hartrampf at the Department of Chemistry, University of Zurich (Switzerland), in collaboration with the company Novo Nordisk in Måløv, Denmar...

jobs.uzh.ch

Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by Alexandra Teslenko at ISIC EPFL, a tour-de-force of single-molecule enzymology! www.biorxiv.org/content/10.1...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Chromatin regulation relies on "writer" enzymes that add post-translational modifications (PTMs) to histone proteins. Variant Polycomb repressive complex 1 (PRC1) exists as several subtypes, which are...

biorxiv.org

Lots of movement on bsky, it’s getting lively!

Want to see how PRC1 writes the Polycomb ubiquitin mark on chromatin, in real-time? Check out our latest preprint, done all by Alexandra Teslenko at ISIC EPFL, a tour-de-force of single-molecule enzymology! www.biorxiv.org/content/10.1...

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Chromatin regulation relies on "writer" enzymes that add post-translational modifications (PTMs) to histone proteins. Variant Polycomb repressive complex 1 (PRC1) exists as several subtypes, which are...

biorxiv.org

Check out the new review from @carlosmyruela.bsky.social on the using synthetic chromatin to investigate the function of histone deacylases! doi.org/10.1042/BST2...

Impressions from the LCBM Xmas party.!Happy holidays!!! 🎄🎁🎅🏽

Check out our work on centro-chromatin, where CENP-A and CENP-B collaborate to generate a dynamic chromatin state! A great collaboration between Nikolina Sekulic’s lab & us, and the labs of Mario Halic and Tatsuo Fukagawa. Congrats Harsh and Ahmad! www.nature.com/articles/s41...

The work of Xingyuu Liu and Jerome Waser, in collaboration with us and the Radenovic lab and funded within project SeleCHEM (ERC), on the gold catalyzed macrocyclization of peptide-EBXs to make fluorescent macrocycles is now in JACS! pubs.acs.org/doi/10.1021/...

Are you a junior scientist 🏋️ in 🇨🇭#chembio, 🔎opportunities for lasting professional relationships & showcase your research? 🧪🔬 👉🏻 ask your PI to join the SNE #ChemBio network! 👉🏻 submit your request bit.ly/3QuphmC #ChemicalBiology #Networking #ChemBio

Another exciting position at EPFL in Life Science Engineering, spanning the disciplines of: synthetic, systems and computational biology, cellular and tissue engineering, biomaterials, functional genomics, proteomics and metabolomics! Find the details here: www.epfl.ch/about/workin...

Congratulations to PhD student Arthur Despois for his poster prize at the joint posters exhibition of SCGC-EDCH! actu.epfl.ch/news/best-po...

We are hiring! We look for Postdocs in the field of biophysics / chemical biology of gene regulation within a context of a SNSF Advanced Grant starting in 2024! More details here: www.epfl.ch/schools/sb/r...

Are you developing new biosynthesis and/or green chemistry approaches? Here is a tenure track faculty position that might be of interest to you! There is less than a month left to apply for this position (deadline Oct 15)! So, apply here and join us at EPFL! www.epfl.ch/about/workin...