Wow - JustEat think ripping off kids is an acceptable business model. Refused to refund my daughter for goods that weren’t delivered because she didn’t know to reposition a pin on a map that their crappy GPS system placed nowhere near the address.
David Bhella
@dbhella.bsky.social
Professor of Structural Virology and Associate Director at the MRC-University of Glasgow Centre for Virus Research (CVR). Director of the Scottish Centre for Macromolecular Imaging. CryoEM, viruses, music, field archery, scicom and pix of our toy poodle.
Interested in learning about cryo-ET on JEOL microscopes? Sign up for a pre-IMC21 one-day workshop in Liverpool 30/08/2026 here: www.imc21.org.uk/congress/pre...
A great collaboration with Morgan Herod and colleagues in Leeds. Thermally stable murine norovirus shows a delayed uncoating phenotype, with cryoEM led by Lee Sherry and Charlotte Lewis at the @cvrinfo.bsky.social.
Enhanced inter-chain hydrogen bonding in the murine norovirus VP1 capsid leads to increased particle stability and delayed viral uncoating https://www.biorxiv.org/content/10.64898/2026.06.30.735626v1
We really appreciate the time and work that @orestissavva.bsky.social put into preparing the PreLights article, and his thoughtful questions were a nice avenue for Charlotte to expand on her work. Thanks to BioRxiv for highlighting this resource.
Community Reviews are science in real time! Check out this new and recent example of open feedback in action: @cb99-lewis.bsky.social et al.’s preprint just got reviewed by a community-organized group through preLights! 📄 doi.org/10.64898/202... (@dbhella.bsky.social) #Preprints #openRxiv
Thanks @juanrv.bsky.social and Denis Ptchelkine for the invitation to visit AFMB and speak at their cryo-EM workshop. What treat to see the beautiful Luminy campus, hear some fantastic science and catch up with @sonia-longhi.bsky.social.
Cats: the ultimate pets and scientific heroes. 🐱 Studying feline viruses to identify innovative solutions to prevent human infections. #preprint by @cb99-lewis.bsky.social, @dbhella.bsky.social & team #microbiology #preLight by @orestissavva.bsky.social: prelights.biologists.com/highlights/i...
Inhibition of VP2-mediated entry: a potential antiviral strategy to treat or prevent calicivirus disease - preLights
Cats: the ultimate pets and scientific heroes. Researchers are studying feline viruses to identify innovative solutions to prevent human infections
prelights.biologists.com
Wow - this is just amazing. Hui Guo and colleagues from John Briggs’ lab use cryoEM helical reconstruction to discover how filamentous influenza virion assembly is directed by multiple conformations of M1 - explaining how NA is concentrated at the proximal pole. www.biorxiv.org/content/10.6...
biorxiv.org
France confines more than 1,700 people to cruise ship over suspected norovirus death
France confines more than 1,700 people to cruise ship over suspected norovirus death
One elderly passenger on vessel docked in Bordeaux has died and about 50 people have symptoms, say officials French authorities have confined more than 1,700 passengers and crew members on a cruise ship docked in Bordeaux after a passenger died from suspected norovirus, officials have said. The Ambassador Cruise Line vessel carrying 1,233 passengers, most of them British or Irish, arrived in Bordeaux on Tuesday. One 90-year-old passenger had died and about 50 people had shown symptoms of the virus, French health officials said. Continue reading...
theguardian.com
Amazing work from Charlotte Lewis - our latest preprint describes structure guided development of an antiviral peptide, targeting VP2 portal assembly - a strategy that may have broad application to treat or prevent calicivirus disease. www.biorxiv.org/content/10.6...
biorxiv.org
Really happy to see this paper out now in PLOS Pathogens - a really nice collaboration with @alanlparker.bsky.social - led by Kasim Waraich and Rosie Mundy. journals.plos.org/plospathogen...
Identification of a novel fiber shaft structural motif and overexpression of key transcripts elucidated in human adenovirus D 10
Author summary Adenoviruses cause infections with pathologies ranging from cold like respiratory symptoms to gastroenteritis and conjunctivitis. In addition to research on adenovirus pathology, substa...
journals.plos.org
How to get ahead in academia 1. Creative thinking. French professor investigated for awarding himself fake prize www.bbc.co.uk/news/article...
French professor investigated for awarding himself fake prize
The academic is accused of dreaming up the prize he went on to win and has been suspended from his university.
bbc.co.uk
First time out in the woods at Palacerigg this year. Not too shabby groups, although my bow feels very heavy… will take a bit of practice before I shoot a round I think.
🚨New pre-print!🚨 Because influenza virions are highly variable in form no single method can show their molecular architecture in detail. Here, we integrate multiple structural and compositional approaches to identify new features of these beautiful virus particles www.biorxiv.org/content/10.6...
Delighted to share our latest preprint describing an integrative model for influenza A virions. We combined proteomics, lipidomics and cryo-ET to build a comprehensive set of models, using subtomogram averaging we show that IAV filaments package cofilactin. www.biorxiv.org/content/10.6...
biorxiv.org
The abstract deadline for the 21st International Microscopy Congress has been extended to 20th March. Pranav Shah and I will be chairing a one-day session on “Imaging pathogen biology from structure to mechanism” and we would love to hear about your work! www.imc21.org.uk
Homepage
imc21.org.uk
A research team from the Max Planck Institute for Multidisciplinary Sciences, the Institut Pasteur, and EMBL has shown in a Nature paper how the influenza polymerase, a molecular thief, uses the host RNA to replicate. Check out the MPI press release: www.mpinat.mpg.de/5179649/pr_2...
Abstract submission closes this Friday. If you have a story to tell and have just seen this do apply! @dbhella.bsky.social and myself look forward to your abstracts!
📣 Submit your abstract for the 21st International Microscopy Congress #IMC21 by *THIS FRIDAY* (6 March) Don't miss the chance to share your work with the global #microscopy community in Liverpool this summer! Abstract submission: https://www.imc21.org.uk/congress/abstract-submission.html
Thanks so much to Profs. Manidipa Banerjee, Ashok Patel, Ramanathan Natesh, Prem Kaushal and Subhash Yadav for inviting me to participate in this years EMBO CryoEM and 3D Image Processing workshop. It is so inspiring meeting all the fantastic students and hearing about their exciting science!
Very excited to share our work, a fish herpesvirus' cryo EM structure. It features a long PVAT tail, with new and host-like proteins discovered using modelAngelo, Dali, and Viro3D, including a host-like macrodomain doi.org/10.64898/202... @dbhella.bsky.social @grovearmada.bsky.social
doi.org
I am excited to share our latest preprint - An evolutionarily divergent herpesvirus with a giant tail. Featuring symmetry breaking and genome annotation from structure using ModelAngelo. doi.org/10.64898/202...
Calling all microscopy enthusiasts! I have been working with Gail McConnell to coordinate the life-science section of the 21st International Microscopy Congress taking place in Liverpool, UK this September. We have some great symposia lined up! Registration and abstracts 👉 www.imc21.org.uk
Homepage
imc21.org.uk
Thanks to @sjorsscheres.bsky.social and Kiarash Jamali for coming to hear me fan-boy about Relion and ModelAngelo in my talk and bringing more advice on how to do cool stuff even better….
Had a fantastic day visiting the Virology Division in the University of Cambridge Dept of Pathology. Thanks to Myra Hosmillo, Ian Goodfellow, Andrew Firth, Hazel Stewart and Valeria Lulla for great virus- and science-life chat.
Had a fantastic day visiting the Virology Division in the University of Cambridge Dept of Pathology. Thanks to Myra Hosmillo, Ian Goodfellow, Andrew Firth, Hazel Stewart and Valeria Lulla for great virus- and science-life chat.
The UK cloud cover forecast for tomorrows geomagnetic storm. If there is one guarantee in life it’s 100% cloud cover when there is a forecast of northern lights. www.bbc.co.uk/weather/arti...
Huge congratulations to Emma Davis, the winner of 2025's Early Career Microbiologist of the Year prize! We agree with Emma that all of the finalists' talks were brilliant and a massive well done to everyone involved!
My nightmare: “Almost 100 people came down with norovirus aboard a Royal Caribbean ship amid a 13-day voyage, the Centers for Disease Control and Prevention reported earlier this week… The first reports of illness were made on Sept. 28, with four crew members and 94 guests falling ill”
Norovirus Outbreak Sickens Nearly 100 on Royal Caribbean Cruise
nytimes.com
This is the coolest resource - so much more than a repository of predicted viral protein structures. Check it out…
Viro3D paper is out! We predicted 85,000 protein structures from human & animal viruses. 1/5 🧵 📑 Paper doi.org/10.1038/s443... 🔭 Explore virosphere viro3d.cvr.gla.ac.uk
Check out this new BBC documentary on Disease X and pandemic preparedness, broadcast tonight (22/09) and on BBC iPlayer. It features @cvrinfo.bsky.social's work using #AI to investigate #virology and much, much more. 🧪🦠🤖 It was a real pleasure working with Chris VT and the team. Thank you!
I am delighted to share this preprint describing the structure and transcriptomics analysis of adenovirus D10 - a fantastic collaboration - and a lot of hard work by Kasim and Rosie.
Identification of a novel structural motif and overexpression of key transcripts elucidated in Adenovirus 10 https://www.biorxiv.org/content/10.1101/2025.09.20.677498v1
Second time in a week - so proud of Charlotte’s achievements. ECR oral presentation prize at the 9th international Calicivirus workshop. So accomplished and just starting year 3 of her PhD.