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Laboratory of Exercise and Health - ETH Zürich

@debocklab.bsky.social

K. De Bock - Passionate scientist at the Swiss Federal Institute of Technology (ETH - Zurich) and proud mother of four children - muscle, vascular biology and metabolism.

28 Posts365 Follower266 Folgt
Cell Metabolism@cp-cellmetabolism.bsky.social · 4mo ago

Online now: How to train your rodent: Recommendations for the preclinical study of exercise-induced benefits in metabolic research

How to train your rodent: Recommendations for the preclinical study of exercise-induced benefits in metabolic research

Regular physical activity is fundamental in promoting health; however, uncovering the molecular adaptations remains challenging in humans. Rodent models have been indispensable for unveiling biological responses to exercise, but performing preclinical interventions can be challenging. Here, we outline key experimental considerations to guide best practices in future preclinical exercise studies.

dlvr.it

Laboratory of Exercise and Health - ETH Zürich@debocklab.bsky.social · 5mo ago

Nice collaboration with @grauperalab.bsky.social and Marc Claret! All credit to them. www.cell.com/cell-metabol...

Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice

Chivite et al. show that the genetic inactivation of the mitochondrial fusion protein MFN2 in the endothelium triggers a protective stress response that boosts fat burning, increases secretion of the ...

cell.com

Laboratory of Exercise and Health - ETH Zürich@debocklab.bsky.social · 7mo ago

Healthy tendons do not contain an extensive #vascular network, so why would I be interested? Well, vascular ingrowth is a hallmark of #tendinopathy! 👇 Look at what Greta discovered! #snedekerlab #debocklab www.science.org/doi/10.1126/...

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment

HIF1α activation promotes tendinopathy, and its inhibition prevents overload-induced maladaptation, suggesting therapeutic potential.

science.org

Andres Hidalgo@drusqui.bsky.social · 8mo ago

Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils "interpret" physiology.

Daniela Cerezo-Wallis@dcerezowallis.bsky.social · 8mo ago

I’m thrilled to introduce you to the NeuMap! our latest work in@nature.com. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour de force www.nature.com/articles/s41...

Laboratory of Exercise and Health - ETH Zürich@debocklab.bsky.social · 11mo ago

Great and unique resource for those who are interested in studying peripheral artery disease mechanisms 👇. Congratulations to Guillermo Turiel and huge thanks to all our collaborators @ethz.ch and Kantonsspital Baden. #PAD #endothelialcells #peripheralarterydisease rdcu.be/eGpZI

Single-cell compendium of muscle microenvironment in peripheral artery disease reveals altered endothelial diversity and LYVE1+ macrophage activation

Nature Cardiovascular Research - Using single-cell and spatial transcriptomics on muscle samples from non-ischemic patients and patients with peripheral artery disease (PAD), Turiel et al. identify...

rdcu.be

Ondine Cleaver@ondinecleaver.bsky.social · last yr.

As scientists, we all need to speak up. Thanks, Guillermo Oliver and @labonnelab.bsky.social for all the science advocacy. 🔬 But we ALL need to be telling our friends, family, and neighbors how important science is. Educate them about the medical cures that came from basic discoveries. #science

Society for Developmental Biology@socdevbio.bsky.social · last yr.

Developmental biologist and former SDB board member Guillermo Oliver published a letter in Science 'US funding freeze threatens biomedical research' in which he highlights the effects of the federal funding freeze on Northwestern University & other institutions. www.science.org/doi/full/10....

Letters US funding freeze threatens biomedical research Guillermo Oliver, Northwestern University Federal funding is crucial for producing cutting-edge scientific, technological, and clinical breakthroughs, allowing universities to cover salaries, purchase reagents and equipment, and enroll patients in clinical trials. Yet in April, funding freezes were enacted at that affect Harvard University, Columbia University, Princeton University, Brown University, University of Pennsylvania, and Northwestern University (1). At Northwestern, almost $800 million has been frozen, without official notification, updates, or recourse (2,3). University faculty and leadership must speak out to make the public and colleagues aware of the funding freeze and to emphasize the dire effects of this policy on research, patients, and public health (4). The frozen funding corresponds to grants that have already been awarded after a stringent, competitive evaluation process that deemed them valuable. To earn a federal grant, basic and clinical researchers must generate and test their results in a laboratory or enroll patients in a long-term clinical trial. Next they must prepare a grant application and submit it to a government funding agency, where a panel of experts carefully reviews it. Only a small number of applications are funded, and it can take up to a year to receive the money. Professors, postdocs, student, and laboratory technicians at US universities come from all over the world to contribute to research projects that could improve human health. Funding freezes with unspecified end dates are demoralizing and stressful, potentially depleting the current and future clinical workforce. Students and postdocs are questioning the viability of a scientific career (5,6), and job applications from domestic and international scientists are likely to decline. These unprecedented, punitive measures against universities and medical schools put both research and patient welfare at risk.
Daniel Drucker@danieljdrucker.bsky.social · last yr.

The emerging vascular biology of GLP-1 medicines in people with #T2D and PAD dom-pubs.onlinelibrary.wiley.com/doi/full/10....

Liraglutide improves peripheral perfusion and markers of angiogenesis and inflammation in people with type 2 diabetes and peripheral artery disease: An 18‐month follow‐up of a randomized clinical trial

Aims In a six-month randomized clinical trial, improved peripheral perfusion has been shown with liraglutide, associated with favourable vascular effects in people with type 2 diabetes and periphera...

dom-pubs.onlinelibrary.wiley.com

Mariona Graupera@grauperalab.bsky.social · last yr.

We are excited to share our work on Context-dependent response of endothelial cells to PIK3CA mutation. A tour the force of many; thank you all for your invaluable contribution. @aangulou.bsky.social @ruibenedito.bsky.social @debocklab.bsky.social @sandradcastillo.bsky.social bit.ly/4blKSqa

Context-dependent response of endothelial cells to PIK3CA mutation

Cancer mutations in the PIK3CA gene cause congenital disorders. The endothelium is among the most frequently affected tissues in these disorders, displaying aberrant vascular overgrowth in the form of...

bit.ly

Laboratory of Exercise and Health - ETH Zürich@debocklab.bsky.social · last yr.

When you're working in an engineering school you end up talking about mechanics ;-). Together with Jess Snedeker-lab, we embarked on studying the molecular mechanisms underlying #tendinopathy. Currently revising the comments of the reviewers, but you can read it now: www.biorxiv.org/content/10.1...

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment

Tendons are mostly avascular dense connective tissues that link muscles to bones, withstanding some of the highest mechanical stresses in the body. Mechanical overload and tissue hypervascularity are ...

biorxiv.org