I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research! ahidalgolab.com Thank you to Gerardo Barcia for his beautiful design and constant support in building it

Hidalgo Lab | Mapping Innate Immunity

Research on neutrophil biology, innate immunity, and cardiovascular disease at Yale School of Medicine. Led by Dr. Andrés Hidalgo.

ahidalgolab.com

I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca

📰 Press Release: Researchers at @yaleschoolofmed.bsky.social have identified a way to suppress the daily fluctuations in the activity of key immune cells known as neutrophils. www.eurekalert.org/news-release... See original paper from the @drusqui.bsky.social group: rupress.org/jem/article/...

What are #Neutrophils? why are there so many? how are they shaped by disease? how is it that they maintain memory despite their short lifespan? Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇 authors.elsevier.com/a/1mFj9L7PXu...

Nature research paper: Architecture of the neutrophil compartment go.nature.com/4oD2Nh5

Architecture of the neutrophil compartment - Nature

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

go.nature.com

Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. Stifter, Greter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...

Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils "interpret" physiology.

Daniela Cerezo-Wallis@dcerezowallis.bsky.social · 8mo ago

I’m thrilled to introduce you to the NeuMap! our latest work in@nature.com. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour de force www.nature.com/articles/s41...

Thrilled to share our Perspective on structural immunity, where we discuss how immune cells double as architects, weaving and reshaping the fabric of our tissues. Grateful to @drusqui.bsky.social, all co-authors, and the wonderful @natrevimmunol.nature.com team for making it such a joy to write!

Nature Reviews Immunology@natrevimmunol.nature.com · 9mo ago

NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM #structuralimmunity #immunosky

Here is a full-text access to a view-only version of the paper: rdcu.be/eM7xA

Structural immunity: immune cells as architects of tissue barriers

Nature Reviews Immunology - This Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in...

rdcu.be

Nature Reviews Immunology@natrevimmunol.nature.com · 9mo ago

NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM #structuralimmunity #immunosky

Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.

Nature Reviews Immunology@natrevimmunol.nature.com · 9mo ago

NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM #structuralimmunity #immunosky

Here's our take on how neutrophils can be a critical link between cancer and cardiovascular disease! "Heart of the matter: Neutrophils, cancer, and cardiovascular disease", just published @jem.org with Saira Ambreen, Afshan McCarthy and @drusqui.bsky.social rupress.org/jem/article/...

🚨 Our new study is live in The Lancet Microbe! “The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study” Led by @jaycrandell.bsky.social , Valter Monteiro and Lauren Pischel www.sciencedirect.com/science/arti... A thread 🧵!

The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study

Cross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbrea…

sciencedirect.com

OBS #Immunology Seminar Neutrophils and regulation of skin physiology 📆 Thu, 10th April, 12 pm EDT/5 pm CET 🎙️ Speaker @alazozcan.bsky.social @yalesph.bsky.social @drusqui.bsky.social @cnic @nature.com 📣 Moderator @eugecc.bsky.social us02web.zoom.us/meeting/regi...

Nature research paper: Matrix-producing neutrophils populate and shield the skin https://go.nature.com/4iJSgy5

Matrix-producing neutrophils populate and shield the skin - Nature

A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

go.nature.com

Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork! Free link: rdcu.be/eeeA2 www.nature.com/articles/s41...

Matrix-producing neutrophils populate and shield the skin

Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...

rdcu.be