Excited to welcome Delphine Bichet and Franck Chatelain to @mrclmb.ac.uk next month. More details (including contact for external attendees) here: mrclmb.ac.uk/news-events/.... Please help to spread the word!
Denise Walker
@denisewalker.bsky.social
Neuroscientist @MRC LMB, 🪱worm tamer, ion channel enthusiast, gardener
Very happy to have this work finally published! How do embryos sculpt their shape? We map the contractile & adhesive forces shaping early C. elegans embryos. With K. Yamamoto @ittoku04.bsky.social G. Charras' lab @gcharras.bsky.social & my team @turlierlab.bsky.social shorturl.at/xv7G5 1/6
Get the skoup! Microglia pinch off neuronal processes containing proteolytic organelles - Shigeki Wanatabe's group terms this garbage removal SKOUPOCYTOSIS. A new class of extra-large extracellular vesicles?!?! Similar to exophers in C. elegans? www.biorxiv.org/content/10.6...
Microglia extract neuronal proteolytic organelles via skoupocytosis
Neurons face unique challenges in maintaining protein homeostasis due to their tortuous morphology and extended processes. Proteolytic organelles are typically transported retrogradely towards their s...
biorxiv.org
After about a year from the preprint, our scRNAseq atlas of the developing Drosophila nerve cord has been published in @nature.com www.nature.com/articles/s41...
A global molecular code for birth order and neuronal identity in Drosophila - Nature
A high-resolution developmental transcriptional atlas of the Drosophila melanogaster nerve cord identifies a shared transcriptional code that records neuronal birth order and organizes neuronal d...
nature.com
In brain development, timing is everything. @sebastiancachero.bsky.social @erikadona.bsky.social & @jefferis.bsky.social have mapped 450,000+ cells from developing fly nervous systems to build an expansive atlas, revealing how neurons 'remember' when they were born. shorturl.at/tfI4s #LMBResearch🧪
Thousands of possible receptor-peptide combinations. One AI-powered solution. Led by @lariferg.bsky.social, a study from @schaferlab.bsky.social & Isabel Beets has developed DeorphaNN, a neural network to identify peptide pairings for GPCRs. Read more: mrclmb.ac.uk/news-events/... #LMBResearch
📣 REGISTRATION IS OPEN 📣 Our 7th annual #BlackInNeuroWeek is coming soon 🧠 From July 27th to August 2nd, we have an ✨AMAZING✨ week of events planned for you all, free and open to the public 🤗 Don’t miss out! Register for #BINW26 here ⤵️ events.zoom.us/ev/AgaErvpe_... #BlackInSTEM #Neuroskyence 🧪
So nice to be involved with this review by @delladavid-lab.bsky.social & coworkers, examining the emerging landscape of the Extracellular Proteostasis Network & its challenges with age @proteostasisuk.bsky.social @babrahaminst.bsky.social @phar.cam.ac.uk febs.onlinelibrary.wiley.com/doi/10.1111/...
febs.onlinelibrary.wiley.com
🎉 New/updated preprint! From 🌟 GS Kirsten Judge + Most neuronal cilia form during development. Can adult neurons rebuild damaged cilia? Are functions restored? Does regrowth use different pathways from ciliogenesis? Answers (in C. elegans): Yes, yes, and partly. 1/6 www.biorxiv.org/content/10.6...
Neuron-intrinsic and glial pathways regulate sensory cilia regeneration in adult C. elegans
Primary cilia are microtubule-based organelles that mediate cellular responses to environmental cues. Although cilia disassemble and reassemble upon cell cycle entry and exit, respectively, in dividin...
biorxiv.org
Glia-released serotonin drives nose touch responses in Caenorhabditis elegans
Glia-released serotonin drives nose touch responses in Caenorhabditis elegans
Touch perception depends not only on neurons but also on active signaling from glia. Using the C. elegans nose touch mechanosensory system, Logan et al. show that glial release of serotonin in response to mechanical stimulation enables neuronal activation and tunes touch sensitivity, with additional feedback signaling refining sensory output.
dlvr.it
🎉Save the date! Black In Neuro Week 2026 is July 27–Aug 2. We're celebrating our 6th annual BIN Week with returning favorites like #NeuroRacism, #NeuroAcrossTheDiaspora, and #BINRollCall plus a brand new theme: #BlackInTime. ✨ 🧠 #BINW26 #AReimaginedFuture
Functional characterization of pathogenic CaV1.1 mutants reveals a pathological role of depolarization-induced calcium release in malignant hyperthermia susceptibility. doi.org/10.1038/s420...
Pathogenic CaV1.1 Variants Cause Hyperpolarizing Shift of Depolarization-Induced Ca2+ Release in Malignant Hyperthermia Susceptibility - Communications Biology
Functional characterization of pathogenic CaV1.1 mutants reveals pathological role of depolarization-induced calcium release in malignant hyperthermia susceptibility.
doi.org
Why does breast cancer so often spread to the brain? 🧠🎗️ New research uncovers a possible mechanism, and identifies a promising therapeutic target. Read about it in Renata’s article! 🔗 www.womeninneuroscienceuk.org/post/why-is-... #Neuroscience #BreastCancer #CancerResearch
A systematic analysis of claudin-like cell adhesion molecule expression in #Celegans nervous system identifies CLC-3 as a neuronally expressed claudin that regulates motor system output. 🪱 Learn more about this work from @kavita-babu.bsky.social lab in #GENETICS: 🔗 buff.ly/30wGQVN
Homelessness among neurodivergent people isn’t just about housing, it reflects repeated failures across support systems.
How gaps in education, work and welfare support can push neurodivergent into homelessness
Homelessness among neurodivergent people isn’t just about housing, it reflects repeated failures across support systems.
tcnv.link
My kids are both doing History in British schools ATM and I was surprised at the lack of WW2 content at GSCE or A Level. Much more US history than I expected - Ford’s new deal, Civil Rights movement. But no Holocaust / Hitler on their exams.
I won't pay $4,000 for a ticket to see my Knicks play in the NBA Finals for the first time in 27 years, but for some reason I routinely pay three times that much for open access to papers that I wrote myself.
Excited to share that our paper on mirror use in octopuses is published today in @currentbiology.bsky.social! This is the first time mirror-mediated spatial navigation has been demonstrated in an invertebrate. 🐙 www.sciencedirect.com/science/arti...
Octopus bimaculoides can learn to utilize a mirror to localize a reward outside the line of sight
Mirror-mediated localization of hidden objects is well documented in vertebrates1,2,3,4,5,6,7,8,9,10,11,12 but has never been demonstrated in inverteb…
sciencedirect.com
Big picture, fundamental research can change lives. Building on work first begun at the LMB in the 1970s, the NHS has begun rolling out a new, injectable cancer immunotherapy. Read more about the new treatment here: www.ukri.org/news/from-mr... #LMBintheNews
From MRC discovery research to a one-minute cancer treatment
A new injectable cancer immunotherapy is being rolled out across the NHS, offering faster treatment for tens of thousands of patients each year.
ukri.org
We’re excited to announce #Worm27 will be in Kobe, Japan, July 18–22, 2027. Join the global Worm community for science, collaboration, and connection in a stunning city between mountains and sea. Save the date—Kobe awaits! What are you most excited for? Tell us below.⬇️
🪱 A new study in the May issue of #GENETICS establishes #Celegans as a model for #Hippo signaling, identifying Hippo-dependent and -independent signals that control WTS-1 in epithelia and intestine, respectively. 🔗 buff.ly/7WfEcYy 📷️ credit: Razan Fakieh
Cambridge friends: come and join us on 14th June. 16 gardens, plant sales, live music, teas and more, all in our beautiful villages of Histon & Impington. Supporting 4 great charities, HI Feast, Deaf Reach, Cambridge Acorn Project and Breast Friends 🌷
One last piece of news to cap off the year.... the Lee lab is now funded by an ✨NSF CAREER✨!!! We'll explore how transgenerational inheritance affects the earliest decisions in C. elegans embryos AND build new CUREs for our first-gen students. 🪱🧬 This is how we feel about being funded! 👇
“If your neighbour’s house is on fire, you don’t wait and watch. You help to put it out before the fire spreads to yours. That’s the interconnected world we live in, and an important lesson for all politicians watching the crisis unfold.” Excellent from @profdevisridhar.bsky.social
Ebola in the DRC needs the world’s attention now – if your neighbour’s house is on fire, you don’t wait and watch | Devi Sridhar
In the interconnected world we live in the west can’t afford to turn away, says Devi Sridhar, chair of global public health at the University of Edinburgh
theguardian.com
The olfactory receptor SNIF-1 mediates foraging for leucine-enriched diets in <i>C. elegans</i>
The olfactory receptor SNIF-1 mediates foraging for leucine-enriched diets in C. elegans
Behavioral analyses combined with genetics revealed that Caenorhabditis elegans uses an olfactory receptor-ligand module to forage for essential nutrients.
buff.ly
“Tommy Chooses Love”. Something positive from this disgusting hate march
Central Bylines@centralbylines.co.uk · 3mo agoThis is brilliant...... “Tommy Robinson’s far right march has unwittingly raised over £100k for refugees. “Over 2,000 of you have chipped in to make tomorrow’s far right march the biggest sponsored walk for refugees EVER.”
So great to see @usbumer1's cool story out at @commsbio.nature.com! Funding thanks DBT and India Alliance. Umer et al have found a role for the neuropeptide FLP-15 in worm foraging. Thanks to all authors and our collaborators @monikakscholz.bsky.social lab. www.nature.com/articles/s42...
FLP-15 functions through the GPCR NPR-3 to regulate local and global search behaviours in Caenorhabditis elegans - Communications Biology
FLP-15 neuropeptide regulates foraging in C. elegans via NPR-3 in dopaminergic neurons, controlling reversal dynamics and spatial exploration during off-food search
nature.com
