👀 Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism Another outstanding contribution to our understanding of HSL, on adipose biology from the team of @dominiquelangin.bsky.social. Such a fascinating story! www.sciencedirect.com/science/arti...

Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism

In adipocytes, hormone-sensitive lipase (HSL) plays a key role in hydrolyzing triacylglycerols that are stored in lipid droplets. Contrary to the expe…

sciencedirect.com

New content online: Adipose tissue thermogenesis is not proportional to temperature

Adipose tissue thermogenesis is not proportional to temperature

Nature Reviews Endocrinology, Published online: 07 August 2025; doi:10.1038/s41574-025-01163-3Adipose tissue thermogenesis is not proportional to temperature

nature.com

Online now: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women

Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women

Dumont et al. reveal that although heat generated by shivering muscles and by the heart increases based on the degree of cold exposure, heat-producing mechanisms present in adipose tissues like brown and white fat respond in an all-or-nothing fashion. In brown fat, the heat produced likely reflects its thermogenic capacity.

dlvr.it

🧪📣Have you ever wondered how shivering and brown adipose tissue interact and respond to different degrees of cold stress in humans?❄️ Conclusion: Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temp in cold-exposed humans. authors.elsevier.com/a/1lRgJ5WXUl...

🧪 Very pleased to have contributed to this important and very comprehensive review on a topic I have thought about for many years - it lays an important foundation to some original human data we hope to put out soon!

Pegah Poursharifi@pegpoursharifi.bsky.social · last yr.

Excited to share our timely and comprehensive review published in Physiological Reviews, bringing together insights from multiple leading labs in metabolism: Marc Prentki and Murthy Madiraju, Shingo Kajimura, @denispblondin.bsky.social, and Christopher Nolan. journals.physiology.org/doi/abs/10.1...

#FridayPhysiologyFact: APS member @denispblondin.bsky.social‬ shares his thoughts with ‪@gretchenxreynolds.bsky.social‬ @washingtonpost.com about whether or not cold plunges are good for us: ow.ly/GEeN50W4oFC #ISpyPhysiology 🧪

🔊PSA: If you are studying BAT in humans...👏Infrared👏Thermography👏of👏supraclavicular👏fossa👏is👏not👏BAT👏THERMOGENESIS!!!!!!! 🧪 Stop saying it is, it's not, and you are actively misleading the field!

⏳Many years in the making, including collaborating with engineers to develop a new temperature control system. This study provides the first ever dose-response of BAT, WAT and myocardial thermogenesis in cold-exposed humans ❄️. We hope to receive some insightful feedback on our findings!

bioRxivpreprint@biorxivpreprint.bsky.social · 2y ago

Shivering, but not adipose tissue thermogenesis, increases as a function of mean skin temperature in cold-exposed men and women https://www.biorxiv.org/content/10.1101/2025.02.24.639578v1

After several decades, in a comorbidity-free U.S.-based population with #T2D the use of GLP-1 RAs did not increase their risk of pancreatitis. Their use was associated with a lower lifetime risk of #pancreatitis www.mdpi.com/2077-0383/14...

Since 2007, there's been a surge in studies investigating the function of BAT. Along the way, there's been much debate on various topics. In this perspective, we highlight the importance of carefully considering your cooling protocol when studying BAT🔥in humans.❄️ www.cell.com/cell-metabol...

Emerging debates and resolutions in brown adipose tissue research

The explosive growth in the study of human BAT has led over time to lively debates over central physiological concepts. This perspective discusses six areas of current disagreement and proposes experiments to achieve resolutions and move the field forward.

cell.com

Our latest review in NJP Metabolic Health and Disease: eur02.safelinks.protection.outlook.com?url=https%3A...

Human adipose depots’ diverse functions and dysregulations during cardiometabolic disease - npj Metabolic Health and Disease

npj Metabolic Health and Disease - Human adipose depots’ diverse functions and dysregulations during cardiometabolic disease

eur02.safelinks.protection.outlook.com

#Tirzepatide for Obesity Treatment & Diabetes Prevention SURMOUNT-1 Trial ✅ Reduced progression to T2DM by 93% #CardioSky #EndoSky #MedSky #NEJM www.nejm.org/doi/full/10....

Tirzepatide for Obesity Treatment and Diabetes Prevention | NEJM

Obesity is chronic disease and causal precursor to myriad other conditions, including type 2 diabetes. In an earlier analysis of the SURMOUNT-1 trial, tirzepatide was shown to provide substantial a...

nejm.org

Created a NeuroMetabolism starter pack. It’s just beginning…who to add?? #neurometabolism #metabolism #brain #peripheralnerve go.bsky.app/4nbSbNR

In our recent paper in @Cell_Metabolism @jananerahbani and no-twitter Jakub Bunk demonstrate that thermogenic adipocytes utilize non-paralogous protein redundancy—through UCP1 and CKB—to promote cold-induced energy dissipation. www.cell.com/cell-metabol...

✅Love cold exposure❄️, heat exposure🔥, or exercise physiology🚴? ✅Looking to do an MSc/PhD/Postdoc🔬? ✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry? Come join us in Sherbrooke, Canada 🇨🇦!