🧵 Following developments in PKD research and clinical trials can be challenging, particularly for patients who are unfamiliar with—or find it difficult to navigate—the information available on ClinicalTrials.gov
Dominique Guerrot
@dguerrot.bsky.social
Nephrology, Hypertension, ADPKD, Clinical investigation | Rouen University Hospital, France
A three-year randomized, double-blind, placebo-controlled study of lanreotide in stage 2/3 autosomal dominant polycystic kidney disease doi.org/10.1016/j.kint.2026.05.018 #NephSky #MedSky #OpenAccess #ADPKD #genetickidneydisease
📖 Don't miss our @kidneyint.bsky.social #ISNFridaySelection: Individual participant-level analysis of four RCT examined therapeutic effects of BP lowering on hierarchical kidney outcome using win statistics https://www.kidney-international.org/article/S0085-2538(26)00233-4/fulltext
Finérénone au-delà du diabète : trois analyses, un même message #ERA26 nephro.blog/2026/06/06/f...
Finérénone au-delà du diabète : trois analyses, un même message
#ERA26 La session de late-breaking clinical trials du 5 juin à Glasgow a réservé vingt minutes au bloc finérénone — trois présentations consécutives, trois publications simultanées dans le New Engl…
nephro.blog
Huge effect of mTOR inhibition (sirolimus, everolimus?) in tuberous sclerosis academic.oup.com/ckj/article/... in @ckj-era.bsky.social Not an RCT of course - rare disease and all that! Via @dguerrot.bsky.social on LI #NephSky
Real-world management of tuberous sclerosis complex–associated renal angiomyolipomas: the impact of mTOR inhibitors
ABSTRACTBackground. Renal angiomyolipomas (AMLs) drive substantial morbidity in tuberous sclerosis complex (TSC) through haemorrhage and repeated invasive
academic.oup.com
Perfect timing for @kireports.bsky.social to publish the IgG4 review as the @nejm.org publishes this RCT of Obexelimab www.nejm.org/doi/full/10....
Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · 3mo agoExcellent review of IgG4 disease and treatment in KIR
💊 How do you taper corticosteroids in patients with ANCA-associated vasculitis? Try CorTapANCA, free interactive tool to prescribe steroid tapering protocols in AAV: 🔗 CorTapANCA App Please repost to help us reach more colleagues. #Nephrology #Vasculitis #AAV #ANCA #Glucocorticoids #KidneyDisease
Safety of kidney biopsies during pregnancy - 1/2nd trimesters academic.oup.com/ndt/advance-... Selection bias as ~ 43% turned out to be lupus? Biopsies were safe, but lot of IUGR and 9% fetal death - likely related to underlying dz and meds and not the biopsy itself
Important metaanalysis presented at #ESH2026 & in The Lancet: In patients with CKD, each 5 mmHg reduction in systolic BP reduced major cardiovascular events by ~9%, with similar relative benefits across CKD stages, proteinuria status and baseline BP levels. linkinghub.elsevier.com/retrieve/pii...
Pour ceux qui rêve d'un système à l'américaine pour maitriser les dépenses de santé. Je mets ça là et puis pour la cour des comptes un des problèmes du déficit c'est peut être aussi les recettes. Choix politique bien évidement.
You ever read a title and feel it reach through your consciousness, tap you on the shoulder, and whisper, "It's all been worth it. Expertise matters."
Monoallelic IFT140 Variants Causing Childhood-Onset Autosomal Dominant Polycystic Kidney Disease bit.ly/3J9ZIWT
EDITORIAL: Guidance on Care for Autosomal Dominant Polycystic Kidney Disease: A Patient Perspective bit.ly/4bIyDEt (FREE)
Le #CJN en mode running c'est le #NEPHRORUN 🦵 l'occasion de visiter #STRASBOURG en brûlant des calories🥨 @dguerrot.bsky.social @mickaelbob.bsky.social @lobbedezt.bsky.social
J'ai lu le rapport provisoire de l'inspection générale des finances sur l'Ordre des médecins. Accrochez-vous, c'est du brutal ! 1/13 x.com/FannyRga/sta...
Fanny Ruz-Guindos on X: "Villa avec piscine, notes astronomiques de champagne et de taxis … Avec @JouanAnne1 nous avons mis la palme sur un document confidentiel de l’Inspection générale des finances étrille l’Ordre des médecins. https://t.co/gtv7FT1ZWp" / X
Villa avec piscine, notes astronomiques de champagne et de taxis … Avec @JouanAnne1 nous avons mis la palme sur un document confidentiel de l’Inspection générale des finances étrille l’Ordre des médecins. https://t.co/gtv7FT1ZWp
x.com
FIND CKD meets primary outcome (GFR slope) in n ~ 1500 with proteinuric non-diabetic CKD Bayer press release: www.bayer.com/media/en-us/... BL data + design paper pubmed.ncbi.nlm.nih.gov/38858818/ in NDT H/T Brendon Neuen on LinkedIn (!)
Urinary dipstick findings and UTI risk with SGLT2 inhibitors: a post hoc analysis of the CANVAS and CREDENCE trials doi.org/10.1093/ndt/...
Saline Doesn’t Ruin Hyponatremia Labs (and it might help) How many times have you been evaluating a patient in the ED and bemoaned the sneaky liter of saline they got before anyone sent some urine for analysis. Turns out it doesn't ruin the labs at all. pbfluids.com/2026/03/sali...
Saline Doesn’t Ruin Hyponatremia Labs (It Might Help)
A study by Dr. Chienwichai highlights challenges in diagnosing hyponatremia due to undisclosed intravenous saline administration. While saline infusion does not obscure urine biochemical tests, it …
pbfluids.com
Great to see the fantastic nephrology podcast community highlighted by #NephMadness 👍 French-speaking listeners may also enjoy #NephrOdio, a nephrology education podcast with 630K downloads to date !
#NephMadness 2026: The PodCrawl Featuring these podcasts: - GN in Ten @isgd.bsky.social - Global Kidney Care @theisn.org - @freelyfiltered.bsky.social - @febrilepodcast.com - Kidney Commute @nkf-professionals.bsky.social - @coreimpodcast.bsky.social - Nephron Segment bit.ly/NM26Podcrawl
#NephMadness 2026: The PodCrawl
Submit your picks! | @NephMadness |@nephmadness.bsky.social | NephMadness 2026 Do you prefer your information in audio form? If so, bookmark this page, where we’ll be sharing links to NephM…
bit.ly
Finerenone improves kidney and cardiovascular outcomes in patients with chronic kidney disease and type 2 diabetes, but its efficacy in type 1 diabetes is unknown. The FINE-ONE trial involving patients with CKD and type 1 diabetes is summarized in a new Quick Take video. nej.md/3PcIJWt
This prospective study in #ASNJASN of 976 adults measured the association between subclinical primary aldosteronism and kidney outcomes. Read more: kidney.pub/JASN1039 Rémi Goupil
🙋♀️🙋♂️ Help shape practice on hypertension in ADPKD! 🔎 An ERKNet survey for adult & pediatric nephrologists, based on a PKD France initiative with support by ERA Kidney & Genes WG and ESPN 🇪🇺 Many thanks for your input ! Dominique Guerrot & Djalila Mekahli
ERKNet Survey | Blood Pressure Management in ADPKD - A European Survey of Clinical Practice
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🙋♀️🙋♂️ Help shape practice on hypertension in ADPKD! 🔎 An ERKNet survey for adult & pediatric nephrologists, based on a PKD France initiative with support by ERA Kidney & Genes WG and ESPN 🇪🇺 Many thanks for your input ! Dominique Guerrot & Djalila Mekahli
ERKNet Survey | Blood Pressure Management in ADPKD - A European Survey of Clinical Practice
Take this survey powered by surveymonkey.com. Create your own surveys for free.
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www.sciencedirect.com/science/arti... Podocyte targeted therapy: TRPC6 inhibition for the treatment of focal segmental glomerulosclerosis: a randomised, placebo-controlled, phase 2 trial of BI 764198
TRPC6 inhibition for the treatment of focal segmental glomerulosclerosis: a randomised, placebo-controlled, phase 2 trial of BI 764198
In focal segmental glomerulosclerosis (FSGS), transient receptor potential cation channel, subfamily C, member 6 (TRPC6) overactivity might cause podo…
sciencedirect.com
Protein Intake and Mortality in Older Adults With CKD url: jamanetwork.com/journals/jam... discovered thanks to @cyrilmousseaux.bsky.social
Protein Intake and Mortality in Older Adults With CKD
This multicohort study estimates the associations of total, animal, and plant protein intake with all-cause mortality in older adults with mild or moderate chronic kidney disease (CKD) and compares th...
jamanetwork.com
Meta-analysis: #SGLT2 inhibitors slow kidney decline consistently across CKD severity and albuminuria range, supporting their routine use for kidney health. ja.ma/4pNzTve
CKD prevalence in elderly and the eGFR inflation effect, a very important paper in the @ndt-era.bsky.social . Not just for elderly but also for the young CKD population academic.oup.com/ndt/article/... #nephinp #nephrology_in_practice
Dans une nouvelle étude des scientifiques de l'Inserm ont analysé comment le système lymphatique se dérègle dans l’insuffisance cardiaque. Ils ont, pour la première fois, identifié les mécanismes responsables de ce dysfonctionnement. Lire le communiqué : presse.inserm.fr/decouverte-d...
Découverte de valves au cœur du système lymphatique cardiaque et de leur rôle dans l’insuffisance cardiaque - Salle de presse de l'Inserm
Dans une nouvelle étude, des chercheurs de l’Inserm et de l’Université de Rouen Normandie, en collaboration avec une équipe de l’Université de Wurtzbourg (Allemagne), ont analysé comment le système ly...
presse.inserm.fr