Fantastic science and fantastic atmosphere at the Ubiquitin Fusion Meeting in Portugal! Many thanks to the organizing team: Florian Bassermann, Henning Walczak, and Vishva Dixit.

Fantastic to be back at Oxford, where I completed my PhD. The Biochemistry Department @oxfordbiochemistry.bsky.social continues to be a true powerhouse of excellence and innovation. A sincere thank you to @robklose.bsky.social and @elliottlab.bsky.social for the invitation and the inspiring science!

Over the past 5 years, 50 structures of full-length HECT-type ligase constructs have been deposited in the PDB. What have we learned from these studies, and what key questions remain open? Check out our new review on this exciting and fast-moving field: www.jbc.org/article/S002...

HECT-type ubiquitin ligases: Emerging principles in the era of full-length structures

Ubiquitin coordinates a complex network of cellular pathways through covalent modification of substrates. Specificity in substrate recognition and modification choice is largely conferred by ubiquitin...

jbc.org

Passionate about ubiquitin biology, its mechanistic underpinnings and therapeutic exploitation? We are looking for a PhD student or postdoc to join our team. Applications and informal inquiries welcome! www.mpinat.mpg.de/19-26?c=3895...

PhD student or Postdoc (f/m/d)- Understanding and manipulating ubiquitin ligase specificities -

The research group Ubiquitin Signaling Specificity (Dr. Sonja Lorenz) invites applications for the position as PhD student or Postdoc (f/m/d) – Understanding and manipulating ubiquitin ligase specifi...

mpinat.mpg.de

Congratulations, Dr. Banos! I am so happy that we will have the opportunity to continue working together in the coming years. Thanks so much to all supporters of Blanca's research and career!

MPI for Multidisciplinary Sciences@mpi-nat.bsky.social · 6mo ago

Blanca Baños receives a Marie Skłodowska-Curie Fellowship🥂🎉! Congratulations! Our postdoctoral researcher @sonjalorenzlab.bsky.social aims to decipher the structural mechanisms by which ubiquitin ligases build ubiquitin chains and to develop new strategies to identify their substrates.

Sledding to the lab - what a great way to start the year! Have a fantastic 2026, everybody!

Exciting! Yet another Spotlight article has come out today in @cp-trendsparasitol.bsky.social, featuring our work on kinase-ligase crosstalk in a Leishmania virulence factor. Thanks so much, @jnpruneda.bsky.social and Shun-Je Bhark! www.sciencedirect.com/science/arti...

Practicing self-control: Leishmania TKUL exhibits intramolecular kinase-ubiquitin ligase crosstalk

Leishmaniasis, a neglected tropical disease caused by Leishmania parasites, poses an immense global health burden in desperate need of additional foun…

sciencedirect.com

Thanks so much, Richard de Heiden and Monique Mulder, for featuring exciting findings on drug-like small-molecule ubiquitination by my research group and that of Jonathan Ostrem. Check out thisTiBS spotlight: www.sciencedirect.com/science/arti...

Drug ubiquitination: an unwelcome mode of action or a novel modality

Recent reports by Orth, Pohl, et al. and Li, Garcia-Rivera et al. show that ubiquitin can mark drug-like molecules in cells. This non-canonical ubiqui…

sciencedirect.com

Exciting opening for a lab technician in the Rink department @mpi-nat.bsky.social: www.mpinat.mpg.de/5123253/36-25 The lab is looking for a technician to support and develop next-generation sequencing applications. Please forward the announcement:

Technische Assistenz (w/m/d) - zur Unterstützung und Entwicklung  von Next-Generation Sequencing Anwendungen -

Die Abteilung Gewebedynamik und Regeneration (Prof. Dr. Jochen Rink) sucht eine Technische Assistenz (w/m/d) - zur Unterstützung und Entwicklung von Next-Generation Sequencing Anwendungen -

mpinat.mpg.de

Tropical disease Leishmaniasis affects the world’s poorest regions. Scientists led by Thornton Fokkens & Sonja Lorenz @sonjalorenzlab.bsky.social have shown that leishmania parasites require the protein TKUL to maintain infections of host cells. 👇 (1/3)

Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators! www.sciencedirect.com/science/arti...

A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity

Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…

sciencedirect.com

Surprising tag: Scientists from @sonjalorenzlab.bsky.social and colleagues have now discovered that the human ligase HUWE1 can tag synthetic drug-like molecules in cells with ubiquitin. Their finding could open up new avenues in drug discovery and biotechnology. @compbiophys.bsky.social

Join us - in person or online - for the Göttinger Literaturherbst, a literature festival with a unique science series. We will feature Katalin Karikó, among other research leaders. Honoured to host Julian Nida-Rümelin on the pressing topic of democracy, 29 Oct. www.mpinat.mpg.de/5094670/pr_2...

We’re excited that our article on the ubiquitination of drug-like small molecules in cells has been selected as an Editorial Highlight in #NatureCommun! 🎉 Check it out here 👉 www.nature.com/ncomms/edito...

Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social ‬ #NatCommun for expertly guiding the winding publishing path. rdcu.be/eDzPk

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1

Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...

rdcu.be

Are you interested in a science policy career? Check out this interesting opening an EMBO! www.embo.org/vacancy/poli...

Policy Assistant, EMBO Policy Programme – EMBO

Your role  As Policy Assistant, you will support the daily operations of the EMBO Policy Programme and contribute to projects on topics such as research assessment, research integrity, and science–pol...

embo.org

Congrats to our lab member, Sait! And thanks very much to all who supported his application! Looking forward to great discoveries to come.

MPI for Multidisciplinary Sciences@mpi-nat.bsky.social · 11mo ago

Congratulations to Sait Şeyhanlı @sonjalorenzlab.bsky.social on securing a coveted Boehringer Ingelheim PhD Fellowship 🎉! The Boehringer Ingelheim Fonds supports exceptional young scientists worldwide in their PhD projects in basic biomedical science. ‬‬‬‬

Summer is now☀️, literature autumn next 🍂📖. The program of the literature festival Göttinger Literaturherbst is out – and our scientific lecture series from Oct 24 to Nov 2 features brilliant Nobel Prize laureates, scientists, & non-fiction authors tackling big questions. Get your tickets!

Congratulations to our lab member, Dr. Thornton Fokkens, for his outstanding research, flawless PhD defense, and smooth climb to the Gänseliesel, the Göttingen landmark that is kissed by all new graduates!

Congratulations to our fantastic @mpi-nat.bsky.social student representatives at the Lindau Nobel Laureates Meeting! Have fun! #LINO25 Delighted that Rosi Junker from @sonjalorenzlab.bsky.social can attend. Many thanks to all supporters, including Brenda Schulman, @embo.org and GGNB Goettingen!

Europe’s choice is clear. To put science at the heart of its economy. To become the home of scientific freedom and collaboration. And to welcome talent from all over the world. I’m glad to present the first elements of our Choose Europe Initiative. → europa.eu/!TTbWbJ

We @natsmb.nature.com recently published an insightful manuscript on ubiquitin-independent proteasomal degradation via the NUB1-FAT10 axis by the lab of Andreas Martin. A very interesting read found here: www.nature.com/articles/s41...

NUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome - Nature Structural & Molecular Biology

Here, Arkinson et al. reconstitute NUB1-mediated FAT10 degradation by the human 26S proteasome and use biochemistry, cryo-EM and hydrogen–deuterium exchange to show that NUB1 acts as an ATP-independen...

nature.com

Fantastic Ubiquitin CSH Meeting! Great science, reunion with old friends and many new contacts. Thanks to the master organizers: @annebertolotti.bsky.social, @labthoma.bsky.social, and Achim Werner!

Hi! Our lab has moved to Bluesky! We will discontinue our Twitter presence in the near future, so please watch out our news here!