First day of AACR: spatial and pups.

@hggadvances.bsky.social's latest article provides systematic evidence that sex-differentiated somatic regulation underlies tumor-intrinsic mechanisms in multiple myeloma, reinforcing the need for sex-aware molecular analyses in precision medicine: https://bit.ly/4s6j2VE #ASH #HumanGenetics

New publication! Lead by Lori Hogencamp, we present the Evolutionary Stress Framework, a complexity-based model that reframes neurodevelopmental variation as the emergent outcome of stress–energy regulation and predictive processing over time. 1/3

Should biology put complexity first? www.sciencedirect.com/science/arti... - excellent essay by @philipcball.bsky.social. I would add epistasis to polygenicity and pleiotropy as a ubiquitous and fundamental phenomenon, not some optional complication that we can try to account for afterwards

Should biology put complexity first?

The dictum “Everything should be made as simple as possible, but no simpler” poses a problem for biology. How simply can it be told without doing dama…

sciencedirect.com

Important and alarming autism news from @rosebroderick.bsky.social at @statnews.com www.statnews.com/2026/01/23/k...

Key autism committee is being reshaped to support Kennedy's vaccine agenda, researchers and advocates fear

Researchers and advocates fear a key autism committee is being reshaped to support Kennedy's vaccine agenda.

statnews.com

I would appreciate if the members of the committee could elaborate and clarify if their goal is truly to “fight against autism”

The idea that America needs to occupy Greenland because we actually care enough about native people and want to build oncology centers is enough to make your head fully explode

Aaron Rupar@atrupar.com · 7mo ago

Waltz: "Denmark has ignored Greenland from a defense standpoint and they have ignored the Greenlandic native iniut people ... if you get a cancer diagnosis in Greenland right now, it's darn near a death sentence. Denmark has not invested in the way it should've over the years."

www.theatlantic.com/science/2026...

Science Is Drowning in AI Slop

Peer review has met its match.

theatlantic.com

I'm happy to share that I will be serving in an ASHG @geneticssociety.bsky.social professional guidance writing group on the participation of people with disabilities in genomics and precision medicine research. 1/2

Join our January #ELSIFridayForum: how genetic embryo selection is being shaped by commercial incentives, regulatory gaps, and shifting cultural expectations of parenthood. January 9th, 2026; 12pm ET/9am PT Register: www.addevent.com/event/kct18q...

Why are more young adults getting appendix cancer? In the latest Cancerwise podcast episode, our experts explain why this rare cancer is often missed and share the latest treatment advances. Listen now: spr.ly/6014COB7p #EndCancer

Cancerwise Podcast

MD Anderson's Cancerwise podcast features insights from our experts on cancer diagnosis and treatment, research breakthroughs, and prevention, as well as stories from survivors and caregivers who've faced cancer firsthand.

spr.ly

HAPPY HOLIDAYS TO ALL OF YOU!🎄✨

One journal editor in chief called the results “concerning,” while another thought the analysis was looking for problems on purpose.

‘Elite cohort’ of biz school scholars and editors scratch each others’ backs, study finds

Image: Mohamed Hassan/Pixabay Academics who publish frequently in two top business journals often have prior working relationships with the editors who handle their papers, according to a new analy…

retractionwatch.com

New pathway discovered!

What Other Diagnoses Could Learn From Autism’s Diagnostic Appeal The role of cognitive-perceptual mechanistic explanations A response by Riva Stoudt to my autism differential diagnosis post www.psychiatrymargins.com/p/what-other...

What Other Diagnoses Could Learn From Autism’s Diagnostic Appeal

The role of cognitive-perceptual mechanistic explanations

psychiatrymargins.com

💯🙌

Abdel Abdellaoui@dr-appie.bsky.social · 8mo ago

For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7

1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...

Mapping the genetic landscape across 14 psychiatric disorders - Nature

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...

nature.com

New preprint alert! Drawing from our experiences and observations on two initiatives with participatory aspirations, we have identified challenges, strategies, and recommendations for better and neurodiversity-affirming autism research. 10.13140/RG.2.2.27146.12481 1/

Someone get me (genetic epidemiologist) & my husband (school psychologist) on a podcast bc our rants on these people are...fiery. We spent 5y in the bay around these folks and oh boy. I'm also so sick of these puff pieces that avoid saying plainly what this actually is. Shoddy science for eugenics.

Hypervisible @hypervisible.blacksky.app · 8mo ago

Tech bros 🤝 eugenics

I'm excited to share that I will be participating in the @sitcancer.bsky.social Sparkathon program, class of 2026. I'm looking forward to connecting with the class and the organizers at the Spring Scientific in Tucson! @tgenresearch.bsky.social

A #ScienceSignaling study examines the activities of ligand-based #CARTcells and shows they induce proliferative signaling events within target cells, a finding that has implications for the design and application of future CAR T cells in the clinic. https://scim.ag/47CxSMB

CSF1R-CAR T cells induce CSF1R signaling and can promote target cell proliferation

Chimeric antigen receptor–stimulated responses in target cells may affect target cell clearance by CAR T cells.

scim.ag

I was interviewed for an article about autism and the gut microbiome published yesterday in @science.org. Check it out! www.science.org/content/arti...

Research linking gut microbes to autism is deeply flawed, critics say

Amid growing investment in the field, a new paper argues it rests on shaky foundations

science.org

What a great webinar featuring @drmbothapsych.bsky.social. An important reminder: dehumanization of autistic people and moral disengagement motivate remediation. pmc.ncbi.nlm.nih.gov/articles/PMC...

ELSIhub | CERA@elsihub.bsky.social · 9mo ago

Genomic and other Autism research raises hopes for improved health outcomes yet also raises concerns. 💡Join our upcoming #ELSIFridayForum to explore the responsibilities of Autism researchers towards the individuals and community they study. Signup: cumc.co1.qualtrics.com/jfe/form/SV_...

Our work was highlighted by @jguerriero.bsky.social at #SITC25 today, session "Cellular Therapies for Solid Tumors, Cell Therapies beyond CAR T Cells." Check out the pre-print on BioRxiv! @sitcancer.bsky.social @sgholamin.bsky.social @nebanovich.bsky.social

Excited to be attending my first SITC Annual Meeting! On Friday, Brandon Fischer from @nebanovich.bsky.social will present a poster on some of our work on Chlorotoxin CAR T cells. Check it out! #SITC25

Society for Immunotherapy of Cancer@sitcancer.bsky.social · 10mo ago

#SITC25 Science Preview: Examine immune regulatory subsets in tumors with Jennifer Guerriero, PhD, Sergio Quezada, PhD, UCL News, @bcellbruno.bsky.social, Florent Ginhoux, PhD and Aurélien Marabelle, MD, PhD Gustave Roussy 🏥 View session details: https://ow.ly/TqBo50XgUsp

#SITC25 Science Preview: Examine immune regulatory subsets in tumors with Jennifer Guerriero, PhD, Sergio Quezada, PhD, UCL News, @bcellbruno.bsky.social, Florent Ginhoux, PhD and Aurélien Marabelle, MD, PhD Gustave Roussy 🏥 View session details: https://ow.ly/TqBo50XgUsp

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @naturehumbehav.bsky.social💰🧬🎓 Link: rdcu.be/efacK Thread below 👇🏽

I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:

What we talk about when we talk about risk

How embryo selection exploits our flawed intuitions about risk

open.substack.com

The use of dichotomized labels for traits that are actually continuous has bothered me ever since I started working on complex trait genetics. Sasha's blog post provides an excellent explanation of why this matters in the context of polygenic risk and embryo selection.

Sasha Gusev@sashagusevposts.bsky.social · last yr.

I wrote about how genetic risk works in the context of embryo selection and how people often think about it all wrong. A short 🧵:

Genetics is transforming lives—but communication is key. Join our webinar to explore how to engage communities, promote understanding, and advocate for justice in genomics. 📅November 12 Register now: learning.ashg.org/products/mee... #ASHG