Back at #BGA2026, in the symposium "Untangling the Web", examining the genetic relationship between psychiatric disorders. Sophie Breunig introducing the symposium and talking first about Prioritizing Modifiable Risk Factors for Psychiatric Disorders via Genomic Structural Equation Modeling

1/9 🚨 BREAKING OUT OF STEALTH MODE 🚨 Multivariate GWAS in Genomic SEM now runs on a laptop! New preprint + package update: a closed-form analytic solution makes multivariate GWAS ~800× faster, cutting runtimes from hours on HPC clusters to minutes on a personal computer.

The Predator Emerges

ALT: The Predator Emerges

static.klipy.com

Also see this write-up in CU Boulder today about the article: www.colorado.edu/today/2026/0...

Mental, physical illnesses often go hand in hand. Genetic study helps explain why

An analysis of DNA from two million people shows that that the same genetic architecture that underlies things like depression, ADHD and substance abuse also

colorado.edu

New Nature Communications paper from IBG graduate student Jeremy Lawrence describes high genetic overlap across 73 physical illnesses (e.g., cancers, heart failure, pneumonia) and internalizing, substance use, and neurodevelopment disorders.🧬 www.nature.com/articles/s41...

If you're looking to build or deepen your knowledge in statistical genetics, the ISG Workshop (June 1–11) covers the full range: biometrics, GWAS, polygenic scores, causal inference, and more. Open to all levels, virtual, and international: www.colorado.edu/ibg/workshop... Retweets appreciated 🙏

1/5 Merola et al. (2026) and Richards et al. (2022) used genomic structural equation modelling (gSEM) to identify latent genetic constructs and explore how they map onto observed traits.

I'm very honored to be recognized for the 2026 Janet Taylor Spence Award. ❤️ Thank you to the APS and congratulations to the other recipients this year!

Association for Psychological Science@psychscience.bsky.social · 6mo ago

Congratulations to the 2026 APS Spence Award Recipients! @dorsaamir.bsky.social, @williambrady.bsky.social, @esfinn.bsky.social, @andrewgrotzinger.bsky.social, @ycleong.bsky.social, @danieljamesyon.bsky.social, www.psychologicalscience.org/members/awar...

Analysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants go.nature.com/3Ymtiwg

Huge genetic study reveals hidden links between psychiatric conditions

Analysis of more than 1 million people shows that mental-health disorders fall into five clusters, each of them linked to a specific set of genetic variants.

go.nature.com

Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed? go.nature.com/48AooC4

Shared genetic risk in psychiatric disorders

Scientists have characterized the broad genetic patterns that are shared across 14 psychiatric disorders. Could it reframe how mental-health conditions are diagnosed?

go.nature.com

Want to echo Abdel and encourage reading this excellent commentary he put together!

Abdel Abdellaoui@dr-appie.bsky.social · 9mo ago

For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7

For more context, see also the @nature.com News & Views article about this work, where I unpack what it means when genetic risk for psychiatric disorders overlaps with normal-range traits, including some positive associations with education-related outcomes: rdcu.be/eT4U7

Andrew Grotzinger@andrewgrotzinger.bsky.social · 9mo ago

1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...

1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...

Mapping the genetic landscape across 14 psychiatric disorders - Nature

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders...

nature.com

IBG is saying a fond farewell to former postdoc @isyfoote.bsky.social. Isy was an invaluable asset to the institute in her time here. She is a Wellcome Trust Fellow and new faculty Queen Mary University of London. We can't wait to see what comes next for this exceptionally bright scholar 🧠🧬!

I'm delighted to say that, as of yesterday, Dr. Isy Foote @isyfoote.bsky.social is now my former postdoc as she is staring a faculty position at Queen Mary University of London. Isy is starting the position with a Wellcome Trust Fellowship 🏆. I couldn't be prouder and she will be sorely missed! ❤️

Our new preprint is out: "Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders"! 🧬🦠 www.medrxiv.org/content/10.1...

Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders

This study explored the genetic links between 11 immune-mediated diseases and 13 psychiatric disorders, addressing the limited understanding of what links these illnesses. Utilizing genomic structural...

medrxiv.org

University of Colorado Boulder Department of Psychology & Neuroscience is searching for TWO tenure track assistant professors. This is open to all department areas, including Behavioral, Psychiatric, and Statistical Genetics🧬 jobs.colorado.edu/jobs/JobDeta...

University of Colorado Boulder Psychology & Neuroscience is searching for TWO tenure track assistant professors!! jobs.colorado.edu/jobs/JobDeta... #socialpsychology #cogpsyc #PsychSciSky #PsychJob #psycjobs #psychology 1/n

Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!

Institute for Behavioral Genetics (IBG)@ibg.colorado.edu · last yr.

New work in Nature Genetics from IBG members lead by @isyfoote.bsky.social (along with @andrewgrotzinger.bsky.social) examining different measures of frailty using Genomic SEM. Findings reveal six genomic factors with unique biological pathways and clinical correlates. www.nature.com/articles/s41...

Some recent data: - First scores for frailty measurements (@isyfoote.bsky.social & @andrewgrotzinger.bsky.social‬): www.pgscatalog.org/publication/... - Comprehensive comparison of type 2 diabetes PGS in Qatari Biobank: www.pgscatalog.org/publication/... Share PGS 👉 www.PGSCatalog.org/submit!

Check out this new work from IBG graduate student @breunigsophie.bsky.social that applies Genomic SEM to examine the relationship between genomic factors for immune-mediated diseases and psychiatric disorders. www.nature.com/articles/s41...

Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders - Translational Psychiatry

Translational Psychiatry - Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders

nature.com

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41... (feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)

Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex - Nature Genetics

Genomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric...

nature.com

One of my talented graduate students (@breunigsophie.bsky.social) is putting together an immune-psychiatric focused symposium submission for the Behavior Genetics Association 2025 meeting in Atlanta. She needs one more talk to fill the symposium; if interested send me a message!

You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2 www.medrxiv.org/content/10.1...

Genomic network analysis characterizes genetic architecture and identifies trait-specific biology

Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...

medrxiv.org

New preprint! www.medrxiv.org/content/10.1... We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis. @andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.social

Genomic network analysis characterizes genetic architecture and identifies trait-specific biology

Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...

medrxiv.org

Exciting post-doc position available working on my NIH funded project "Longitudinal multi-omic biomarkers for neurocognitive decline prior to dementia onset". Based in the beautiful city of Edinburgh within @edinunilbc.bsky.social elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Postdoctoral Research Associate

The Lothian Birth Cohorts Group within the Psychology Department, School of Philosophy, Psychology and Language Sciences is seeking a PDRA on a full time, fixed term contract until 30th of June 2025 i...

elxw.fa.em3.oraclecloud.com

If you're not following the Behavior Genetics Association account yet (@behaviorgenetic.bsky.social), please do! 🧬🧠🤸🏽 Me and Margot van de Weijer will be running it for the time being, sharing BGA updates and summaries of interesting research from their classic journal 📜 RTs appreciated! 🙏🏽

🚨Writing to say that I am actively recruiting PhD students in the clinical -or- behavioral, psychiatric, and statistical genetics program (BPSG) at CU Boulder for a Fall 2025 start date. My lab focuses on genomic methods development and applications to psychiatric and aging outcomes (e.g., dementia)

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders https://www.medrxiv.org/content/10.1101/2024.07.18.24310651v1

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders https://www.medrxiv.org/content/10.1101/2024.07.18.24310651v1

Importance: Autoimmune and autoinflammatory diseases have been linked to psychiatric disorders in th

medrxiv.org

New preprint just dropped! 🧬🦠 For this project, we looked at the genetic relationships between psychiatric disorders and immune-mediated diseases. Check out the full paper here: www.medrxiv.org/content/10.1...

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders

medRxiv - The Preprint Server for Health Sciences

medrxiv.org