Ben Kuznets-Speck
@biophysben.bsky.social
Biophysicist working at the edge of single cell biology, machine learning, and statistical-mechanics. Incoming Assistant Professor at Fred Hutch. Postdoc at Northwestern; PhD in biophysics, UC Berkeley; BS in math and physics, CWRU.
This is just a fucking carjacking. How the hell was he supposed to know it was a state sponsored carjacking. what the fuck are we doing here.
Aaron Reichlin-Melnick@reichlinmelnick.bsky.social · 2w agoThe NYPD just released surveillance video of the ICE shooting (which occurred off camera). Two men in civilian clothes run up to a car with guns drawn. One second later, one man begins smashing the butt of his gun into the driver’s side window. The driver appears to panic and hit the gas.
Postdocs! Excellent opportunity to work with @biophysben.bsky.social! The Kuznets-Speck Lab is seeking a Postdoc Fellow to develop statistical and machine learning methods for single cell and omics data, with room to pursue independent research directions. careers-fhcrc.icims.com/jobs/31990/p...
Fred Hutchinson Cancer Center
Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.
careers-fhcrc.icims.com
Thrilled to be recruiting a postdoc to work with me Fred Hutch! See below for details:
Fred Hutch Biostatistics Program@fredhutchbiostat.bsky.social · 2w agoPostdocs! Excellent opportunity to work with @biophysben.bsky.social! The Kuznets-Speck Lab is seeking a Postdoc Fellow to develop statistical and machine learning methods for single cell and omics data, with room to pursue independent research directions. careers-fhcrc.icims.com/jobs/31990/p...
I see that @anthropic.com is now competing with PhD students in Biology/Bioengineering labs, whose biggest worry until now was being inevitably scooped by the Feng Zhang and Jennifer Doudna labs. Very different from Wild West days of RT discoveries in my PhD. www.anthropic.com/news/claude-...
Claude discovers a novel enzyme system
In early results from our new life sciences research lab, Claude agents found an enzyme system whose function is still unknown.
anthropic.com
Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.
Fred Hutch Basic Sciences Division@basicsci.fredhutch.org · 3mo agoJoin @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.
We have been fortunate to have our community enriched by a remarkable stream of Fellows, both theorists and experimentalists. This is our annual effort at renewal. Please apply if it looks like a good fit!!
@cpbf.bsky.social · 2mo agoApply here! apply.interfolio.com/188492
🎉 Welcoming @biophysben.bsky.social to our Biostat Program in January 2027! He works across ML, physics, and biology, using generative models to map genetic drivers of disease, infer gene networks from sister cell data, and predict cellular responses from gene co-fluctuations. 🎉benkuznets-speck.com
👀 We are super excited for Ben to bring his energy and ideas to Fred Hutch. Welcome, @biophysben.bsky.social !!
Ben Kuznets-Speck@biophysben.bsky.social · 4mo agoThrilled to announce I'll starting my lab in Biostatistics at Fred Hutch Cancer Center, where we'll fearlessly cross the boundaries of statistical physics, AI, and single-cell biology to study drug resistance, metastasis, and immune exhaustion! Huge thanks to everyone who made this possible.
Thrilled to announce I'll starting my lab in Biostatistics at Fred Hutch Cancer Center, where we'll fearlessly cross the boundaries of statistical physics, AI, and single-cell biology to study drug resistance, metastasis, and immune exhaustion! Huge thanks to everyone who made this possible.
A cartoonist named Daniel "Des" Rolando Sanchez Estrada was tried as a terrorist and sentenced to 30 years in prison for having anti-Trump comics in his car. Prosecutors connected him to a 2025 anti-ICE protest he didn't even attend because he was in the same book club as others who were.
30 years for moving a box of zines. Des Sanchez Estrada was not even at the noise demo that led to this. The state is attempting to make an example of these anti-fascist political prisoners. We can expect the crackdowns to continue & escalate. Take this seriously. Don't back down
People’s City Council - Los Angeles @pplscitycouncil.bsky.social · 8mo ago"Wearing All Black at Protests Makes You Guilty of Terrorism, Prosecutors Tell Jury The Prairieland case is a major test of the Trump administration’s push to label “antifa” protesters as terrorists." All eyes on Prairieland 👀 Read: theintercept.com/2026/03/12/a...
They can control the copy right but we're all Tarheels. The Tar Heels ARE for everyone, and the UNC administrators who deleted this can go to hell.
Jesus Christ this is the most chilling thing I've read in ages. The "new understanding of truth" described here is not new in any way, it is basically a return to pre-literate dark ages & the inevitable result is going to be fascism.
Gen Z Is Pioneering a New Understanding of Truth
The first generation to truly grow up online, Generation Z and their cohort live in a social media ecosystem that blends facts and feelings. It’s significantly shifting how they understand what’s true...
wired.com
Travel applications for our upcoming workshop, ‘Cell State Transitions and Fate (in)decisions,’ are due in one week! Don’t miss your opportunity to join a community formalizing a unified framework for understanding plasticity and cell state-fate relationships www.nitmb.org/cell-state-t...
Just in: Supreme Court rules against law banning conversion therapy for minors. 8-1 decision. Justice Ketanji Brown Jackson was the lone dissenter. www.huffpost.com/entry/suprem...
Supreme Court Rules Against Law Banning Conversion Therapy For Minors
The justices ruled 8-1, with Justice Ketanji Brown Jackson as the lone dissenter.
huffpost.com
Breaking news: A federal judge found that the IRS violated federal law “approximately 42,695 times” when it shared confidential taxpayer addresses with immigration enforcement officials last summer.
Judge: IRS broke law ‘approximately 42,695 times’ in giving DHS data
A court on Thursday issued an opinion on a data-sharing agreement between the taxpayer agency and federal immigration authorities.
wapo.st
Shame on NYU Langone for ending gender-affirming care & kicking trans New Yorkers to the curb. It's a violation of their promise to treat all people equally, kindly, and respectfully — and a violation of NYC's human rights law as well. Bending the knee is bad; denying people care is even worse.
The nazis redistributed the stolen property of deported Jews to the German population. It was called Aryanization. This is no different. en.wikipedia.org/wiki/Aryaniz...
Aaron Rupar@atrupar.com · 9mo agostraight up Gestapo shit
Out in @physrevlett.bsky.social: @sfuphysics.bsky.social postdoc Antonio Patrón Castro (in tight collaboration with my colleague John Bechhoefer) pushes our information engine to higher dimensions! doi.org/10.1103/xwjd...
Harnessing Higher-Dimensional Fluctuations in an Information Engine
We study the optimal performance of an information engine consisting of an overdamped Brownian bead confined in a controllable, $d$-dimensional harmonic trap and additionally subjected to gravity. The...
doi.org
So excited to be co-organizing this!! If you're in the Chicago area, I highly recommend you join us for this 2.5 day workshop -- we have stellar speakers talking about all sorts of theory and biology. Make sure to apply before the deadline if you are interested!
NSF-Simons NITMB@nitmb.bsky.social · 9mo agoJoin a community of early-career researchers across disciplines inspiring new avenues of collaboration across the experiment-theory spectrum! Applications for the ‘Curiosity-Driven Dialogue and Collaboration Between Experiment and Theory’ workshop are due TOMORROW, January 23rd Application 🔗 ⬇️
Excited to share new work by Daiki and Hector in collaboration with Monika: arxiv.org/abs/2512.13859 We introduce a gating mechanism in classic associative memory models and find capacity is increased far above the Hopfield limit without the usual catastrophic breakdown.
Neuromodulation-inspired gated associative memory networks:extended memory retrieval and emergent multistability
Classical autoassociative memory models have been central to understanding emergent computations in recurrent neural circuits across diverse biological contexts. However, they typically neglect neurom...
arxiv.org
Super happy to be associated with this work !!
Ben Kuznets-Speck@biophysben.bsky.social · 11mo agoToday we’re excited to share Keeping SCORE, a framework that turns any diffusion model into a thermodynamic inference machine. Using only a model’s score function, we compute exact class likelihoods and uncertainty—and even decompose which features drove the decision. www.biorxiv.org/content/10.1...
NEW PREPRINT led by stellar postdoc @biophysben.bsky.social We turn diffusion models into inference machines. Score function→exact likelihoods, uncertainty estimate & interpretablity. Diffusion models generate. But classify? Untapped—until now @chanzuckerberg.bsky.social shorturl.at/s32uX
Interpretable Thermodynamic Score-based Classification of Relaxation Excursions
Classification and regression are cornerstones of computational biology and science at large, from identifying cell types to stratifying patients by disease state. Current deep learning classifiers pr...
shorturl.at
Ben Kuznets-Speck@biophysben.bsky.social · 11mo agoToday we’re excited to share Keeping SCORE, a framework that turns any diffusion model into a thermodynamic inference machine. Using only a model’s score function, we compute exact class likelihoods and uncertainty—and even decompose which features drove the decision. www.biorxiv.org/content/10.1...
Today we’re excited to share Keeping SCORE, a framework that turns any diffusion model into a thermodynamic inference machine. Using only a model’s score function, we compute exact class likelihoods and uncertainty—and even decompose which features drove the decision. www.biorxiv.org/content/10.1...
Not sure why @lpachter.bsky.social did not post this here. But it is brilliant. Single cell genomics finally makes it to the clinic.
excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social looking to hire 2 postdocs to join us in this endeavor. more details can be found here: sites.google.com/uw.edu/statp...
SPE - join us
Postdoctoral position: In January 2026, we are relocating to Yale university to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI). We are looking for talented postd...
sites.google.com
Babies who are threat to DHS = 0 DHS teargas grenades thrown at babies = More than 0 (Before anyone blames adults for bringing baby there, video shows woman pull baby from her obstructed car to escape area. No indication she was there for a protest.)
Don Moynihan@donmoyn.bsky.social · last yr.Yeah, that is a tear gas canister being fired toward the retreating couple holding the baby
