Maybe corny but it was helpful for me to hear Henry Rollins saying "this is not time to be dismayed, this is punk rock time, this is what Joe Strummer trained you for... You can be thunderous in your own life, to the eight people around you. That rubs off... Goodness is viral"

The Papua New Guinea Courier is in rare form.

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Nice paper showing ~1/540 people have a sex chromosome trisomy from 3 large biobanks (UKB, FinnGen, MVP) comprising 1.5 million individuals along with their phenotypic impact. www.medrxiv.org/content/10.1...

Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals. Browse scans at: mvp-ukbb.finngen.fi

I agree with this, and would add that data of regulatory annotations doesn't cover all cell types where the variant effect might be driving the trait association. scATAC probably has the best coverage of cell types, but it's not perfect either.