1/10 🧵 Suomalainen media ei kyseenalaista, miksi markkinoiden luottamus on se itsestäänselvä lähtökohta, josta talousuutisia kirjoitetaan. Ilmiö näkyy selvästi, kun vertailee kahta juttua samasta pääministeristä. Ero paljastaa jotain oleellista.👇

13. Hence our dismal conclusion: rather than finding that LLMs free us to do a better job of what we were doing before they came along, they shift scientific incentives (and the playing field of academic competition) in ways that compel us to do more and more, faster and faster, less and less well.

1/13 🔎 Olen ihan oikeasti yrittänyt hahmottaa, mihin Kokoomuksen maine talousosaajana perustuu. En löydä sille kovin vahvaa näyttöä tuloksista: velkasuhde on noussut, kasvu ollut heikkoa ja työllisyyskehitys vaihtelevaa myös sen hallitusvastuun aikana. 🧵⬇️

Mikko Tuomi@mustapipa.bsky.social · 3w ago

Aivan kuin tässä oltaisiin yhteiskuntana hiljalleen havahtumassa sellaisiin kiusallisiin tosiasioihin, että: 1) Oikeiston talousosaaminen on huijausta 2) Ahneus on oikeiston toimintaa määrittävä tekijä 3) Oikeiston äänestäjät kärsivät Tukholma-syndroomasta www.is.fi/politiikka/a...

📢 #TOPMed e/sQTL atlas is out in @science.org today! Happy to contribute to this amazing team effort and rich resource for the genomics community: 69k cis-eQTL + 35k cis-sQTL across 6 tissues/cell types and diverse ancestries. Still more to discover 😉🧬 www.science.org/doi/10.1126/...

Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed

Most genetic variants associated with complex traits are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we characterized 14,324 RNA-sequen...

science.org

Very happy to share our pre-print co-led with Nathan Andrews where we reveal splicing and isoform changes in a single-cell CRISPRi screen. For example, GEMIN5 knockdown produced minimal gene expression changes yet extensively reshaped the isoform landscape.

Tuuli Lappalainen@tuuliel.bsky.social · 4w ago

With my postdocs Nathan Andrews and @josiegleeson.bsky.social , we demonstrate the importance and analyze methods for isoform-level resolution in single cell-CRISPR perturbations. TL;DR: Long reads are the way. 3/3 www.biorxiv.org/content/10.6...

Excited to share two new preprints from the lab! 1/3 www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...

We're recruiting! An open functional genomics postdoc position at @scilifelab-ngi.bsky.social / my lab / Robert Månsson lab. Top notch environment for technology and applications development in lovely Stockholm. Please spread the word or apply if interested: www.kth.se/lediga-jobb/...

Very good piece by @tuuliel.bsky.social @nevillesanjana.bsky.social @singht.bsky.social & colleagues: “Current challenges in GWAS integration and fine-mapping for variant interpretation” 🧪🧬 www.biorxiv.org/content/10.6...

Current challenges in GWAS integration and fine-mapping for variant interpretation

Over the past two decades, genome-wide association studies (GWAS) have identified thousands of trait- and disease-associated loci. However, the mechanistic understanding of these loci remains incomple...

biorxiv.org

“move from preprint to peer-reviewed publication leaves the central claims of most abstracts intact, indicating preprints are a reliable source…papers that were never posted as preprints were retracted at roughly twice the rate of those that were…” www.biorxiv.org/content/10.6...

Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models

Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...

biorxiv.org

Suomen talouden korjatut kasvuluvut osoittavat entistä selvemmin, että Orpon hallitus on onnistunut tuhoamaan suomalaisia työpaikkoja tuhatmäärin keskellä vahvaa suhdannetta. #talous #politiikka

The proposed cap, and to some extent the current limit to 6 proposals per FY, dismantles MPI science. Less collaboration will be the result.

TK (Takashi DY) Kozai@bioniclab.bsky.social · last mo.

🧪 One U19 with four MPIs charges four slots for one shared budget. Four sole-PI R01s charge four slots for four separate budgets. Same cap cost, very different funded science, so MPI roles are the first thing PIs drop under renewal pressure.

I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review. open.substack.com/pub/blekhman...

My Peer Review of The 1%

I wanted to like QED's new 1% ranking. I don't.

open.substack.com

NIH grants have been under political scrutiny since early 2025. But what does the screening process actually look like? What is being flagged? I spent a month digging into leaked docs and emails. We've published the 235-word list that are being flagged by an internal AI tool. And so much more. 🧵

Inside the new political screening that’s stalling NIH grants

Mandatory reviews by top health officials and checks for 235 disfavoured terms have left hundreds of vetted grant applications in administrative limbo.

nature.com

Arvoisa sosiaali- ja terveysministeri Wille Rydman. Poliitikkojen tehtävä ei ole ohjailla, mitä saa tutkia. Heidän tehtävänsä on varmistaa, että tiede saa riittävät ja vakaat resurssit. tieteentekijat.fi/poliittinen-...

We regret that our event on Extreme Heat: Improving governance and strengthening action around the world has been cancelled due to the red extreme heat warning issued by the UK Met Office. Our apologies to everyone who was planning to attend the event.

Unpopular opinion: Going straight to AI limits your creatively, because it short-circuits the iterative process you need to develop new ideas.

A unique job opportunity to work on some of the most exciting genomic datasets in the world!

Institute for Molecular Medicine Finland (FIMM)@fimm-uh.bsky.social · 2mo ago

The Computational and Statistical Genomics Group led by @srubinacci.bsky.social at FIMM, together with @finngen.bsky.social project, is looking for a Genomics Data Analyst with skills to ensure that our WGS and WES data are harmonized & analysis-ready. Apply here: 🔗 jobs.helsinki.fi/job/Helsinki...

Happy to share that this work led by @mihkeljesse.bsky.social has now been published at PLOS Genetics! journals.plos.org/plosgenetics... A couple of thoughts below.

Ultra-fast genetic colocalisation across millions of association signals

Author summary Over 90% of human genetic variants associated with human traits and diseases lie in non-coding regions of the genome, making it difficult to interpret the mechanisms by which these vari...

journals.plos.org

@mihkeljesse.bsky.social · 11mo ago

After 1.5 years of work in @kauralasoo.bsky.social’s lab, we finally published my preprint! We introduce gpu-coloc, a GPU-accelerated implementation of coloc, show comparability to CLPP and aim to provide practical guidelines. Now accessible on BioRxiv: www.biorxiv.org/content/10.1...

🏆 Congratulations to Tuuli Lappalainen, ESHG Award Lecturer 2026! In her Award Lecture, Professor Lappalainen will discuss the next steps in interpreting these effects and the tools that will help researchers uncover the molecular mechanisms underlying genetic variation. #Genetics #eshg2026

Next up, Adam Ameur shares that long-read WGS efforts are ongoing in Sweden for population genomics and clinical diagnostics. They bridge these projects by using a joint analysis framework and shared variant databases. #ESHG2026 #PacBio #ESHG

New Yorkers singing Empire State of Mind

To all attending #eshg2026: if you are ready to spent extra attention to detail throughout the entire conference, I recommend the informal ESHG bingo card. Brought by our great postdoc @lydiasagath.bsky.social @eshg.bsky.social First bingo gets a kanelbullar from me… tinyurl.com/eshgbingo2026

ESHG 2026 BINGO

Play virtual ESHG 2026 BINGO with your friends for free on any device. Customize the bingo cards and generate printable or virtual bingo cards for free.

tinyurl.com

🚀 #EASIGEN-DS is heading to #ESHG2026 Join us at the 59th ESHG conference that brings together leading experts across the field for four days of intensive collaboration!🧬 🏆 Don’t miss the ESHG Award Lecture by @tuuliel.bsky.social, our WPs leader, who has been honored with this year’s award

Petteri Orpo pyysi katsomaan tuloksia. OK, tehdäänpä niin. 1/4

Petteri Orpolta kahden sanan täyslaidallinen kriitikoilleen: ”Katsokaa tuloksia” – IL seuraa

Kokoomus pitää puoluekokouksensa Jyväskylässä. Iltalehti seuraa tapahtumia läpi viikonlopun.

iltalehti.fi

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

We are gliding serenely towards the worst El Niño in recorded history as Iran War hamstrings food industries across the globe

We built a joint experimental and computational platform for scalable multi-modal single-cell chemical screens — profiling RNA, protein (including phospho-signaling), and chromatin accessibility responses to thousands of small molecule perturbations in parallel. www.biorxiv.org/content/10.6...

It’s truly astonishing to see how comprehensively the US government is tearing down every part of the system that has made it up until now a world-leading power in science, research, and technological development. The entire world will suffer from this wanton destruction.

Dan Vergano@danvergano.bsky.social · 2mo ago

White House proposes new rules giving political appointees final approval of research grants These proposed Office of Management and Budget regulations would render the federal research grant review process opaque www.scientificamerican.com/article/whit...