Using data from more than 1,100 Finnish blood donors participating in FinnGen, @masakanai.bsky.social and colleagues have created an atlas of over 10 million immune cells that links disease-associated genetic variants to the genes they control. The findings were just published in @nature.com.

Our single-nucleus immune multiome atlas is now out in @nature.com! 🧬 10M PBMCs from 1,108 @finngen.bsky.social donors recruited by Finnish Blood Service, profiled at @broadinstitute.org with chromatin accessibility and gene expression in the same nuclei, to trace how disease variants act 🧵👇

FinnGen-tutkimusaineistoa on hyödynnetty ensimmäisessä laajassa fibromyalgiaan keskittyvässä geenitutkimuksessa. Tulokset osoittavat, että sairauden taustalla on keskushermoston poikkeava tapa käsitellä kipua, ja auttavat näin ymmärtämään fibromyalgian syntyä: 🔗 www.finngen.fi/fi/edistysas...

Edistysaskel kipututkimuksessa: geenit osoittavat keskushermoston merkityksen fibromyalgian taustalla | FinnGen

Suuri kansainvälinen tutkimus on löytänyt uusia fibromyalgialle altistavia geneettisiä riskitekijöitä. Löydös auttaa ymmärtämään fibromyalgian syntyä ja voi vauhdittaa uusien hoitojen kehittämistä.

finngen.fi

Pregnancy-related liver disease remains poorly understood, but genetics is helping to change that. A recent study identified novel genetic factors associated with intrahepatic cholestasis of pregnancy, providing new insights into the disease mechanisms. Read more: www.tuni.fi/en/tau/news-...

Large-scale genetic study uncovers new factors associated with a pregnancy-related liver disease | Tampere University

Intrahepatic cholestasis of pregnancy (ICP) is the most common liver condition that occurs during pregnancy and is characterised by a disruption in the normal flow of bile from the liver. A new int...

tuni.fi

FinnGen-based study by Nina Mars, Joni Turunen and colleagues demonstrates that polygenic risk scores can identify individuals at substantially increased risk of developing glaucoma and those whose disease is likely to progress more rapidly. Read more: www.helsinki.fi/en/news/gene...

Genetic information helps predict the onset and progression of glaucoma | University of Helsinki

Polygenic risk scores can identify individuals at substantially increased risk of developing glaucoma and those whose disease is likely to progress more rapidly. A new screening model based on these f...

helsinki.fi

A unique job opportunity to work on some of the most exciting genomic datasets in the world!

Institute for Molecular Medicine Finland (FIMM)@fimm-uh.bsky.social · 4mo ago

The Computational and Statistical Genomics Group led by @srubinacci.bsky.social at FIMM, together with @finngen.bsky.social project, is looking for a Genomics Data Analyst with skills to ensure that our WGS and WES data are harmonized & analysis-ready. Apply here: 🔗 jobs.helsinki.fi/job/Helsinki...

FinnGen-konsortioon kuuluvat tutkijat Oulun yliopistosta ovat tunnistaneet kymmeniä uusia geneettisiä riskitekijöitä lannerangan selkäydinkanavan ahtaumalle. Tutkimus auttaa ymmärtämään paremmin tätä yleistä selkäsairautta. Lue lisää @oulu.fi tiedotteesta: www.oulu.fi/fi/uutiset/s...

Suuri geenitutkimus paljasti uusia riskitekijöitä yleiselle selkäsairaudelle

Tutkijat tunnistivat kymmeniä uusia geneettisiä riskitekijöitä lannerangan selkäydinkanavan ahtaumalle.

oulu.fi

FinnGen-konsortioon kuuluvia tutkijoita Itä-Suomen yliopistosta on osallistunut kansainväliseen yhteistyötutkimukseen, jossa tunnistettiin yli 90 Alzheimerin taudin riskiin liittyvää geneettistä aluetta. Laaja meta-analyysi tuotti uutta ymmärrystä taudin biologiasta. 🔗 www.uef.fi/fi/artikkeli...

Tutkijat tunnistivat yli 90 geenialuetta, jotka liittyvät Alzheimerin taudin riskiin

Tulokset korostavat immuunijärjestelmän, beeta-amyloidin, tau-proteiinin sekä rasva-aineenvaihdunnan keskeistä roolia Alzheimerin taudissa.

uef.fi

We are pleased to announce the release of FinnGen DF13 results! 🧬 While the number of participants remains unchanged, DF13 incorporates updated health register data, increasing the number of cases across most disease endpoints. Browsing & download instructions here: www.finngen.fi/en/access_re...

We’re looking for a Project Manager to join our FinnGen team in Helsinki! The role centers on financial management of a major international research collaboration project. If keeping complex projects financially on track are your thing, this might be for you! jobs.helsinki.fi/job/Helsinki...

Two inspiring days at the FinnGen meeting at Novartis, Cambridge! Partners shared latest insights from FinnGen data across diseases & advances in biobank-scale analyses. Just as important were discussions on the future, outlining the next phase of FinnGen. Many thanks to our hosts and participants!

Tutkimuksemme kärjet ovat Tulevaisuuden teknologiat, Oppivat ja muuntuvat yhteiskunnat, Yksilöllinen terveys ja Kestävä planeetta. www.helsinki.fi/fi/uutiset/y...

Helsingin yliopisto on tunnistanut neljä tutkimuksen kärkeä – monitieteinen huippututkimus kohtaa aikamme suuret haasteet | Helsingin yliopisto

Helsingin yliopisto on tunnistanut neljä tutkimuksen kärkeä, jotka kokoavat yhteen yliopiston tutkimuksen vahvuudet. Kärjet yhdistävät ihmis-, elämän- ja luonnontieteellistä huippututkimusta ja vastaavat aikamme keskeisiin haasteisiin.

helsinki.fi

Large-scale FinnGen-based study by Reeve et al., just published in Nature Genetics, provides the most detailed genetic map of autoimmune hypothyroidism to date and reveals a surprising inverse relationship between hypothyroidism risk and skin cancer risk. www.broadinstitute.org/news/study-r...

Study reveals genetic balancing act between autoimmunity and cancer risk

Researchers pinpoint genetic factors linked to both higher risk of a common autoimmune disorder and lower cancer risk

broadinstitute.org

Tiesitkö, että FinnGen-tutkimuksessa tuotettu genomitieto on palautettu takaisin näytteen toimittaneeseen biopankkiin? Veripalvelun biopankissa on pilotoitu tähän tietoon perustuen hemokromatoosin riskitiedon palauttamista biopankkiin kuuluville verenluovuttajille: www.veripalvelu.fi/verenluovutt...

Verenluovuttajat saivat ensimmäistä kertaa tietoa perinnöllisestä sairausriskistä

Suomen Punaisen Ristin Veripalvelun biopankista palautettiin tietoa riskistä sairastua hemokromatoosiin eli tautiin, jossa elimistöön kerääntyy liikaa rautaa.

veripalvelu.fi

The largest genetic study of anxiety disorders to date has identified 58 genetic variants associated with anxiety. The research, published in Nature Genetics, was based on data from >120,000 individuals with anxiety disorders, from various cohorts, including FinnGen. www.nature.com/articles/s41...

🌍 On #WorldCancerDay we recognise those in the BBMRI-ERIC community working to advance cancer research. 🔬 In our first post, we looked at EU projects. Let's turn the spotlight on the researchers & biobankers driving cancer innovation - The teams behind the data, discoveries & breakthroughs. 🧵 1/2

FinnGenin suomalaisten partnerien edustajat tapasivat eilen Biomedicumissa Helsingissä ja etäyhteyden välityksellä. Kiitos kaikille osallistujille aktiivisuudesta tutkimuksen seuraavan vaiheen suunnittelussa!

This week, Aarno Palotie and Mark Daly are visiting our Finnish partner organisations presenting what FinnGen has achieved and discussing how to develop it in the future. Great that the seminars, organised with help from the analysts that support FinnGen locally, have turned out to be popular!

We've been contributing to an international study identifying 13 genetic markers associated with infection with the Omicron variant of the coronavirus. The study, led by Statens Serum Institut, was recently published in Nature Genetics: 🔗 www.nature.com/articles/s41... 🔗 en.ssi.dk/news/news/20...

New study finds distinct genetic risk factors for infection with the Omicron variant of the coronavirus

Genetic differences may influence the risk of infection with the highly transmissible Omicron variant, and the patterns differ from earlier coronavirus variants, according to a new large international...

en.ssi.dk

New preprint 👇 Does diagnostic misclassification in EHR-based psychiatry GWAS suppress genetic discovery? We use simulations and FinnGen data to expand the SuperControl framework and propose a new ML approach (PRISMA) to boost signal discovery. Led by Lisa Eick & Zhiyu Yang!

On behalf of all of us in FinnGen team, we wish you Happy Holidays and a wonderful New Year full of exciting scientific discoveries! Thank you for being part of the FinnGen community and for helping move this effort forward together. 🧬❄️

Kindly note that the URLs for our publicly available meta-analysis result browsers have been updated. The browsers are now accessible at: ➡️FinnGen + pan-UKBB meta-analysis results: public-metaresults-fg-ukbb.finngen.fi ➡️FinnGen-MVP-UKBB meta-analysis results: public-mvp-ukbb.finngen.fi

FinnGen@finngen.bsky.social · 2y ago

Million Veteran Program & FinnGen teams are pleased to release v1 meta-analysis of MVP, FinnGen and UKBB GWAS data. This first version includes ~300 binary disease definitions across >1.5 M individuals. Browse scans at: mvp-ukbb.finngen.fi

Autumn semester publication wrap-up! 📄 This autumn, FinnGen researchers contributed to a remarkable set of papers across human genetics, medicine, and methods; spanning @natgenet.nature.com, @natcomms.nature.com, Hypertension, @ajhgnews.bsky.social and more. Here’s a 🧵 highlighting these studies ⬇️

We are looking for a Software Developer to join our international team in Finland! With us, you will gain invaluable experience in high-impact software solutions that empower researchers to analyse and visualise extensive genomic and health data. Apply by 30 Jan: jobs.helsinki.fi/job/Helsinki...

Excited to share our new FinnGen single-nucleus multiome preprint! 🧬 We profiled ~10M PBMCs (snRNA-seq + snATAC-seq) from 1,108 Finnish donors to map how genetic variants drive complex disease through chromatin and gene regulation 🧵👇 🔗 Link: www.medrxiv.org/content/10.1...

Researchers from the University of Edinburgh carried out the largest genetic analysis of delirium to date, drawing on data from several study cohorts, including FinnGen. The results demonstrate that APOE contributes to delirium susceptibility independently of dementia. www.ed.ac.uk/news/study-f...

Study finds gene linked with risk of delirium | News | The University of Edinburgh

A major genetic risk factor for delirium has been identified in a landmark study that analysed the DNA of more than one million people worldwide.

ed.ac.uk

In a new study, @hheyne.bsky.social and her team identified a Finnish-enriched missense variant in the SCN5A gene that acts like a natural lifelong cardiac sodium channel blockade, decreasing the risk of cardiac arrhythmias while also having some negative effects. hpi.de/en/article/h...

HPI study finds advances in the treatment of heart disease

HPI researchers Dr. Henrike Heyne, Julian Wanner and their team discover gene variant that acts like heart medication. Their study has now been published.

hpi.de

Check out our new article in #Circulation on an astonishing genetic variant in the ion channel #SCN5A that enables us to learn about #cardiac-arrhythmia and their treatment with sodium channel blockers. @finngen.bsky.social www.ahajournals.org/doi/10.1161/... Congrats to @jwanner.bsky.social

Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade | Circulation

BACKGROUND: Atrial fibrillation and other cardiac arrhythmias pose a major public health burden, but prevention remains difficult. We investigated a genetic variant that we found to act like a natural...

ahajournals.org

Depression in young adulthood has a stronger hereditary component and is associated with a higher risk of suicide attempts than depression that begins later in life, according to a new study led by researchers @ki.se, including FinnGen as one of the study cohorts: news.ki.se/genes-may-pr...

Genes may predict suicide risk in depression

Depression in young adulthood has a stronger hereditary component and is associated with a higher risk of suicide attempts than depression that begins later in life, according to a new study published...

news.ki.se

We are proud to welcome Alnylam Pharmaceuticals as the 15th pharma company to join our public-private partnership! Alnylam brings world-leading expertise in RNAi therapeutics to the consortium, further enriching the scientific and translational potential of the study. www.finngen.fi/en/alnylam-b...

Alnylam Becomes Newest Partner in FinnGen Consortium | FinnGen

FinnGen is proud to welcome Alnylam Pharmaceuticals as its newest industry partner. As the 15th pharmaceutical company to join the public-private partnership, Alnylam brings world-leading expertise in...

finngen.fi