Today (May 15) is the last day to get your special edition @rnacanada.ca RNEh? tshirts to celebrate your Canadian RNA pride at #RNA2026 @rnasociety.bsky.social. Order here: gametime.gearware.com/stores/rna! Delivery ONLY to RNA2026 in MTL/no shipping. Image design by Jasmine Tsang.

RNA Canada ARN is excited to be at the 2026 RNA Society Meeting. We will be set up at a table in the exhibition hall! Stop by to talk with RNA Canada members, grab some free swag, and sign up to renew your membership. !

The small GTPase Arf1 regulates TORC1 in two different ways! Great work by Ludovic Enkler and a great collaboration with @mihaelazavolan.bsky.social . Check out our preprint! www.biorxiv.org/content/10.6...

And there's more meetings.embo.org/event/26-gen...

Lots of things RNA going on early summer 2026 and I'm looking forward to Montreal! www2.rnasociety.org

How does a major liver function, protein synthesis, change when the organ can't cope anymore with challenges and cancer develops? Here's what we found: www.biorxiv.org/content/10.6... Another productive collaboration with Salvatore Piscuoglio. Thanks to my great team - Asier, Meric, Aleksei & co!

Context: Gene expression noise has been observed to decrease with growth rate in E. coli. journals.plos.org/plosbiology/... Consequently, fast growing cells are more phenotypically stable, and this has major implications for phenotypic adaptation www.pnas.org/doi/10.1073/... 2/n

Genome-wide gene expression noise in Escherichia coli is condition-dependent and determined by propagation of noise through the regulatory network

Genome-wide flow cytometry measurements reveal that gene expression noise in bacteria is highly condition-dependent; while absolute noise levels of all genes decrease with growth-rate, theoretical mod...

journals.plos.org

What are the main sources of gene expression noise in bacteria, and why do slower growing bacteria exhibit more expression noise? TLDR: we found growth-rate fluctuations are a key driver of gene expression noise that increase as average growth rate decreases. www.biorxiv.org/content/10.6... 1/n

Sad day... way too soon

SIB Swiss Institute of Bioinformatics@sib.swiss · 8mo ago

We are deeply saddened to share the passing of Amos Bairoch, pioneer of bioinformatics and co-founder of SIB. His lifelong commitment for high-quality, open data transformed global research. We honour his legacy by continuing to build the future of bioinformatics.

Is this f*g real? The comedic tragedy we're living in.

Aaron Rupar@atrupar.com · 11mo ago

"Don't take Tylenol!" -- Trump has said this about a dozen times during this press conference

Are you excited to pursue your own research interests and contribute to our group’s experimental research in the quantitative biology of microbes? We have an opening for a potentially permanent position as research associate. Please repost and notify potential candidates!

Biozentrum, University of Basel@biozentrum.unibas.ch · 11mo ago

Research Associate (100%) Starting from 1 November 2025 or as per agreement Group @erikvannimwegen.bsky.social @biozentrum.unibas.ch @unibas.ch www.biozentrum.unibas.ch/open-positio... #job #research #biology #microbiology #science #basel #recruiting #career

What novel biological dynamics might be hiding under the measurement noise of your time-lapse fluorescence microscopy data? Try our new RealTrace tool to find out! Fantastic work by Bjoern Kscheschinski and others. Tweetorial follows. 1/n www.biorxiv.org/content/10.1...

RealTrace: Uncovering biological dynamics hidden under measurement noise in time-lapse microscopy data

One of the most powerful approaches for identifying the mechanisms underlying complex biological phenomena is not just to measure bulk populations, or even take single-cell snapshots, but to directly ...

biorxiv.org

Publication by the Becskei & Zavolan labs w/ co-1st authors Asier González, Muskan Pandey & Niels Schlusser "Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines" in Scientific Data buff.ly/WYwzw5V @mihaelazavolan.bsky.social @biozentrum.unibas.ch

Hey there, #mRNAtranslation buffs! Our latest multi-faceted dataset from liver cancer cell lines is out in #ScientificData: RNA-seq, ribosome run-off/ribo-seq, polysome-seq, pSILAC. rdcu.be/eC86H. Great team effort spearheaded by Asier Gonzalez Sevine and Niels Schlusser. Happy data crunching!

Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines

Scientific Data - Multi-omic assessment of mRNA translation dynamics in liver cancer cell lines

rdcu.be

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

Sarafan ChEM-H@stanford-chemh.bsky.social · 11mo ago

Open faculty position! We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa

🤔 Can migrating cells 'remember' their past trajectories? In collab w/ @sgabriele.bsky.social & @kyohalie.bsky.social, we address this question: Confined cells undergo geometry-sensitive morphology switches, and these switches depend on the past migration history! www.nature.com/articles/s41...

The actin cortex acts as a mechanical memory of morphology in confined migrating cells - Nature Physics

Cells often navigate through confined spaces. Now it is shown that cells retain a mechanical memory of previous confinement events, which makes them more efficient at migrating through narrow microenv...

nature.com

The key point here is rather "who would your rather trust"? Because what is offered is not for anyone to decide for themselves, but rather one is coerced to go along with decisions made by few. People are expected to follow the orders of someone who understands nothing.

Carl T. Bergstrom@carlbergstrom.com · 12mo ago

1. "'Trusting the experts is not a feature of either a science or democracy," Kennedy said." It's literally a vital feature of both science and of representative democracy. I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.

OTD in 1949 Soviets forcibly deported 30,000 people from Moldova, after we had "liberated them from fascism". Imagine mass deportations happening today...

Right! Maybe these folks who like to push others into various spheres of influence should try living there.

The Kyiv Independent@kyivindependent.com · last yr.

⚡️NATO expansion 'fair' concern for Putin, Kellogg says.

Really nice to see some fresh initiatives on the Romanian science scene 1health.ro/biotech-boot... kudos to the biomentorhub.ro and all those who made this possible.

Biotech Bootcamp 2025 – One Health Incubator

1health.ro

Back to reality www.brainonllm.com. Now imagine the cognitive debt on stuff that involves some abstraction...

Your Brain on ChatGPT: Accumulation of Cognitive Debt when Using an AI Assistant for Essay Writing Task

Your Brain on ChatGPT: Accumulation of Cognitive Debt when Using an AI Assistant for Essay Writing Task

brainonllm.com

RNase L cleaves most tRNAs in the anticodon loops into various tRNA-derived RNAs (tDRs) including 5'-tDRAla that shows a translation inhibitory effect. Some tRNAs are also cleaved in variable loops bit.ly/3YTwlNq

'Data analysed by the BBC show that Ukraine's Western allies have paid Russia more for its hydrocarbons than they have given Ukraine in aid.' What a bleak set of statistics.

How the West is helping Russia to fund its war on Ukraine

Data shows that Russian fossil fuel revenues are three times higher than aid allocated to Ukraine.

bbc.co.uk

It's really happening: AI-enabled noise injection in scientific information, from which models are trained, for more automated noisy inferences... journals.plos.org/plosbiology/...

Bonsai is out! Finally, we can visually explore high-dimensional data in a distortion-free way. Try it out! It works from scRNA-seq data (bonsai.unibas.ch/bonsai-scout...) up to football statistics (bonsai.unibas.ch/bonsai-scout...). 
Ever wondered why low-dimensional embeddings like t-SNE

Erik van Nimwegen@erikvannimwegen.bsky.social · last yr.

Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...

An alternative to tSNE & UMAP for more accurate data visualization: Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data. The trees are constructed to accurately represent true distances between the objects in the high-dimensional space.

Amazing tour-de-force through the representation and analysis of scRNA-data analysis from @dhdegroot.bsky.social @erikvannimwegen.bsky.social‬, with strikingly deep implications. Oranje boven! 😂

Erik van Nimwegen@erikvannimwegen.bsky.social · last yr.

Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

Integrative analysis of RNA binding proteins identifies DDX55 as a novel regulator of 3′UTR isoform diversity

The 3′ untranslated regions (3′UTRs) of mRNAs play a critical role in controlling gene expression and function because they contain binding sites for microRNAs and RNA binding proteins (RBPs) that alt...

biorxiv.org

Bacteria have a simple yet potent mechanism that controls their sensitivity to environmental stimuli. A new study by researchers led by @erikvannimwegen.bsky.social @biozentrum.unibas.ch shows: the slower cells grow, the more sensitively they respond to their environment.

Slow-growing bacteria respond more sensitively to their environment

Bacteria have a simple yet potent mechanism that controls their sensitivity to environmental stimuli. A new study by researchers at the Univer...

unibas.ch

This is how you do it!

Darth Putin@darthputinkgb.bsky.social · last yr.

Day 1165 of my 3 day war. A Ukrainian sea drone costing $250k converted 2 Russian fighters, worth $60,000,000, into submarines. I remain a master strategist.