Cortical expansion and genetic risk for PD. Led by Houman Azizi and Nooshin Abbasi. With @ptenigma.bsky.social @misicbata.bsky.social @yasharneuro.bsky.social @ndrewvo.bsky.social and many others www.medrxiv.org/content/10.6...

Brain size links neurodevelopment to neurodegeneration in Parkinson's disease

Genetic studies have advanced our understanding of Parkinson's disease (PD) pathogenesis, establishing a role for autophagy and lysosomal dysfunction. However, how genetic risk translates into neurona...

medrxiv.org

Why does your brain shrink in Parkinson’s? Word shrink in this case refers to measurable loss of brain tissue (atrophy), which reflects thinning of cortex/loss of volume in key brain regions. New paper shows widespread atrophy following brain’s wiring diagram and local biological vulnerabilities.

Being an academic means 25% of your time is spent approving 2FA requests and resetting your password for journal portals 😑

New preprint. @ndrewvo.bsky.social‬ and @enigmabrains.bsky.social‬ analyzed MRI of > 3,000 people with Parkinson’s disease. W-score method to compare PD to matched controls confirmed extensive loss of cortical thickness, surface area and subcortical volumes in PD, even in early stages

Convergent large-scale network and local vulnerabilities underlie brain atrophy across Parkinson's disease stages: a worldwide ENIGMA study https://www.medrxiv.org/content/10.1101/2025.05.25.25326586v1

how long before this thing descends into the dumpster fire that is/was academic twitter? 🫣