Our lab has just launched a new website! 🎉🧫 Take a look at our research projects and meet the people behind the science at the Developmental Resilience Lab, based at @iribhm.bsky.social @ulbruxelles.bsky.social . dejaimesoguero-lab.ulb.be

Our paper about predicting cell fates from combinatorial signals in 2D human gastruloids received a preprint highlight in @dev-journal.bsky.social Thank you @ancheldjs.bsky.social for a great perspective piece on our work! 👉 journals.biologists.com/dev/article/...

David Brückner@davidbrueckner.bsky.social · 3mo ago

Can a snapshot of cell signaling predict cell fate? 🤔 Combining iterative immunofluorescence, information theory & machine learning we show that combinatorial signaling encodes fate at single-cell level in 2D human gastruloids This reveals an interpretable & generalizable signal-to-fate map 🗺️

Interested in stem cell-based models of early mammalian development? Our JoVE Methods Collection is actively seeking exciting new contributions. If you have a novel method, protocol, or perspective, we'd love to hear from you—reach out and submit an abstract! www.jove.com/methods-coll...

Meet our Preprint Editors We are pleased to welcome our first group of Preprint Editors to our editorial team, responsible for handling our 'In preprints' articles. #preprints journals.biologists.com/dev/pages/ed...

Excited to be part of the first cohort of Preprint Editors at @dev-journal.bsky.social @biologists.bsky.social I will discuss selected preprints in stem cell biology, embryogenesis, signaling & genome integrity. Contact me if you come across an interesting preprint that you wish to highlight!

New hypothesis paper: the anterior–posterior (A–P) axis in early embryos may do more than pattern the body—it could create gradients of genome stability, with anterior regions more error-prone and posterior regions protected by morphogen signaling. 🧬 onlinelibrary.wiley.com/doi/10.1002/...

🚨 PhD opportunity Interested in stem cells, mammalian development, and omics? The Migeotte & De Jaime-Soguero labs are recruiting a PhD student with bioinformatics background to work on embryonic and extraembryonic development. 🗓 Deadline April 2026 👇 Details below www.iribhm.org/open-positio...

PhD Position — IRIBHM Jacques E. Dumont

Anchel De Jaime Soguero Lab: PhD position in cellular and developmental biology

iribhm.org

🚨 Paper alert! The final version of our latest manuscript is published. We are excited to share this new resource for the zebrafish community and beyond: doi.org/10.7554/eLif... Congratulations to all authors! 🥳

A single-cell transcriptomic atlas reveals resident dendritic-like cells in the zebrafish brain parenchyma

The zebrafish brain combines a conserved heterogeneity of immune cells with a unique dendritic cell-like population.

doi.org

Beautiful, thorough, personal in places, memoir of John Gurdon from Eddy de Robertis, disciple and friend. Å #MustRead about a generation and a time from which we have moved on but that laid the foundation for contemporary biology. www.sciencedirect.com/science/arti...

Cellular signaling (BMP/SMAD) at the helm of chromosomal instability in cancer, similar as what we described during development and lineage specification. Congrats to our collaborators at the Bastians lab.

bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 8mo ago

SMAD4 loss drives cancer chromosomal instability through transcription-replication conflict-induced replication stress https://www.biorxiv.org/content/10.64898/2025.12.17.694873v1

‼️‼️📢📢 Job Alert! Our lab at @iribhm.bsky.social - @ulbruxelles.bsky.social is seeking for a PhD student to work on the proteostasis of early mammalian development using stem cell models and the embryo. If you are enthusiastic about cell and dev biology, please apply!

Excited to present our work tomorrow online at Social DNAing series. 18.00PM CEST time following the link below.

Zha Lab@zhalab.bsky.social · last yr.

Are you ready for the 2nd half of 2025? Social DNAing is ready. Check out the speaker list and schedule! Sign up at www.cancer.columbia.edu/research/pro...

The modularity of the mammalian #embryo in display. Controlled assembly of classic #gastruloids and uncommitted precursors in #hypoxia, patterns the AP axis www.biorxiv.org/content/10.1... Beautiful & insightful from @bulutkarslioglu.bsky.social‬ group. Building models to learn and learning.

Crick researchers have developed a new stem cell model of the mature amniotic sac development. The team is now exploring the potential for using these new 3D models in clinical applications, such as cornea reconstruction and treating ulcers. www.crick.ac.uk/news/2025-05...

New stem cell model sheds light on human amniotic sac development

Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four wee...

crick.ac.uk

Join us tomorrow for our next seminar: 🗓️ Thursday, May 08 ⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET

Virtual Gastrulation Zoom Talks@vgzt2021.bsky.social · last yr.

Next Western 🌙 VGZT coming up: 🗓️ Thursday, May 08 ⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET 👉 @ancheldjs.bsky.social (Regulation of chromosome segregation fidelity across lineage specification) 👉 @emmanuelhaillot.bsky.social (Mesoderm and endoderm formation in Nematostella)

Looking forward to giving this talk next week!

Virtual Gastrulation Zoom Talks@vgzt2021.bsky.social · last yr.

Next Western 🌙 VGZT coming up: 🗓️ Thursday, May 08 ⏰ 9:30 PDT / 12:30 EDT / 16:30 UTC / 17:30 BST / 18:30 CET 👉 @ancheldjs.bsky.social (Regulation of chromosome segregation fidelity across lineage specification) 👉 @emmanuelhaillot.bsky.social (Mesoderm and endoderm formation in Nematostella)

Aneuploidy is the leading cause of pregnancy loss. In work led by @saracarioscia.bsky.social and @aabiddanda.bsky.social, we reanalyzed genetic testing data from 139,416 IVF embryos to discover variants associated with recombination phenotypes and aneuploidy risk. www.medrxiv.org/content/10.1...

Last few months have been of change. I finished my postdoc at @cosheidelberg.bsky.social and moved to Belgium to begin my research group at @iribhm.bsky.social. I will reflect here my thoughts about the last years experience.

In this Review, @eliananehme.bsky.social, @amiteshp.bsky.social, Isabelle Migeotte and @pasquelab.bsky.social give an overview of the embryonic origin and function of extra-embryonic mesoderm in vertebrates from in vivo studies. journals.biologists.com/dev/article/...

Do you want to illuminate your studies on innate immune responses? Our new biosensor monitors mtDNA from apoptosis, viral infections, other sources of dsDNA and environmental cGAMP. We also show that micro nuclei are poor activators of the #STING response

The EMBO Journal@embojournal.org · last yr.

SIRF: Sergio Acebron @acebronsp.bsky.social @cosheidelberg.bsky.social and colleagues develop a new #biosensor reporting on functional interactions between dsDNA sensor STING and #IRF3, allowing to capture STING activation upon various triggers www.embopress.org/doi/full/10....

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.   Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

Design of a STING fluorescent real time biosensor. Tour de force of my colleague #Steve under Sergio @acebronsp.bsky.social supervision. 👏👏👏

The EMBO Journal@embojournal.org · last yr.

SIRF: Sergio Acebron @acebronsp.bsky.social @cosheidelberg.bsky.social and colleagues develop a new #biosensor reporting on functional interactions between dsDNA sensor STING and #IRF3, allowing to capture STING activation upon various triggers www.embopress.org/doi/full/10....

Novel insights on cellular signaling regulation of DNA replicative dynamics. BMP signaling not only prevents from replicative stress in pluripotency, as we described recently (www.nature.com/articles/s41...) but also drives regeneration through same mechanisms. www.nature.com/articles/s41...

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress - Nature Communications

Zebrafish show robust heart regeneration after injury. Here they show that zebrafish cardiomyocytes experience replication stress, which BMP signaling alleviates via a conserved mechanism of replicati...

nature.com

Surprisingly we find that as few as 2 starting p53KO cells will compete in an environment of @300 WT cells. Also, see an input for BMP & Wnt signalling that mirrors work on the control of chromosomal segregation in stem cells www.nature.com/articles/s41...

Great work on cell competition during mammalian gastrulation. It aligns with our observations on chromosome stability-driven by morphogens and open further questions on the relation of cellular fitness and genome integrity. Congrats!

Alfonso Martinez Arias@amartinezarias.bsky.social · 2y ago

1/3 Embryogenesis requires fit cells. Here, following work from @miguel-torres-1963.bsky.social & @tristanrodriguez72.bsky.social and led by @joshifrenster.bsky.social we develop a #gastruloid model of #CellCompetition www.biorxiv.org/content/10.1... showing it recapitulates much of the embryo 🧵

Great city, great environment and cool projects (including stem cell modelling, development, homeostasis and cancer biology). Have a look to the research groups offer and do not hesitate to apply!

IRIBHM Jacques E Dumont@iribhm.bsky.social · 2y ago

🎉 We’re pleased to announce the launch of the IRIBHM Jacques E. Dumont International PhD Programme 2025! A great opportunity to shape the future of biomedical sciences by preparing the next generation of leaders. 🚀 Don’t miss your chance to be part of this innovative adventure! iribhmphd.ulb.be

Great opportunity for a PhD in Brussels. Outstanding mentor and project addressing bottlenecks in human development

Anchel de Jaime-Soguero@ancheldjs.bsky.social · 2y ago

🚨 🚨 Job Alert! I am currently opening my research lab at @iribhm.bsky.social @ulbruxelles.bsky.social in Belgium and I am seeking for an enthusiastic PhD candiate to study cellular stress across mammalian development and lineage specification! If you are interested, info below. Please RT!

⚠️📢 Few weeks to close the call. If you love cell & devbio, and are interested on doing a PhD in stress resilisence, please APPLY!

Anchel de Jaime-Soguero@ancheldjs.bsky.social · 2y ago

🚨 🚨 Job Alert! I am currently opening my research lab at @iribhm.bsky.social @ulbruxelles.bsky.social in Belgium and I am seeking for an enthusiastic PhD candiate to study cellular stress across mammalian development and lineage specification! If you are interested, info below. Please RT!

Gracias a Pilar Perla y @heraldo.es por la difusión de nuestro trabajo en el lab de Sergio Acebrón @acebronsp.bsky.social y mi opinión sobre la investigación básica en mi tierra, Aragón. www.heraldo.es/noticias/ara...

Anchel de Jaime Soguero: "Aragón necesita dar un impulso a la investigación básica"

Tras pasar por Alemania, el biomédico aragonés lidera su propio grupo en el Instituto Interdisciplinar de Biología Humana y Molecular, en Bruselas.

heraldo.es

Registration is open for the 12th Advances in Stem Cell Biology Course #ASCBcourse at the @pasteur.fr Hands-on training in different models, embryonic stem cells, iPS cells and much more on #StemCells. 🕘June23-July04, 2025 👉https://qrfy.io/VEcoKQpGfV