Alfonso Martinez Arias
@amartinezarias.bsky.social
Interested in how cells use genes to create shape, form and function in #embryos as well as in Societal Wellbeing #NotInTheGenes #InNumbersWeTrust #gastruloids #gastrulation
Over 15 years of our work consistently supports a cohesive model of neurodegeneration providing useful concepts and directions for future research: "the dependency cycle of local axon homeostasis". Enjoy the read of our completely revamped manuscript: doi.org/10.1101/2025... (PDF fixed)
© Summer Jane. 'Composure,' 2024. Palette knife acrylic painting. 70 × 90 cm.
Well, this is a surprise. Weng'an Biota (Doushantuo Formation), where some can be interpreted as embryos and within them….some suggestive images. Probably not what I think I see but #Amazing. #PreCambrian lyellcollection.org/doi/full/10....
Tribute to Gail Martin www.sciencedirect.com/science/arti... Discoverer of #EScells whose curiosity went beyond cells, genes / embryos. Good for younger generations to learn @ these giants. NB. Unfathomable why she was overlooked for a Nobel Prize, though this says more @ prizes than @ her.
A true giant of #DevBiol! For you youngsters who might not know, among her decades of fantastic discoveries was this thing she found in 1981 that she called "Embryonic Stem Cells." I think some people still study them. Thanks to Alex for writing this lovely piece!
Developmental Biology@devbiol.bsky.social · 3w ago#DBfeature A tribute to Gail R Martin, mouse geneticist and mentor extraordinaire (April 12, 1944 - Feb 9, 2026) By Alexandra Joyner doi.org/10.1016/j.ydbio.2026.05.007
For those of us of a certain age his work, that changed the way we think @ the #ImmuneSystem and answered a key question - #AbDiversity- was an inspiration in an era of true discoveries S. Tonegawa l1nq.com/a3rwkdo
In the midst of foundational models of the cell (or should I say pseudocell), seen as an “bag”, this www.cell.com/cell/fulltex... is a great antidote, and one that anyone who knows that a cell is more than its genes, can relate to and understand #RealCellsRUs #NotInTheGenes
Establishing a conceptual framework for holistic cell states and state transitions
Technological advances have brought “big data” to the cellular level. Rafelski and Theriot share their vision of defining a cell's state in a holistic way that reflects all molecular, organizational, ...
cell.com
🚨 New pre-print alert! 🚨 Adult neural stem cell state and fate decisions are hidden within transcriptional heterogeneity. To find out how we decoded these heterogeneities to identify a molecularly encoded quiescence cycle, check out the pre-print on bioRxiv! doi: doi.org/10.64898/202...
My image "The phases of gastrulation" made it to the top 10 in this year #YEN2026 image competition! I took this video of a gastrulating 🐸 embryo while testing a new microscope in the lab. One of the rare #devbio theme videos I got. Check out the others here: thenode.biologists.com/results-of-t...
“move from preprint to peer-reviewed publication leaves the central claims of most abstracts intact, indicating preprints are a reliable source…papers that were never posted as preprints were retracted at roughly twice the rate of those that were…” www.biorxiv.org/content/10.6...
Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models
Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...
biorxiv.org
This www.nature.com/articles/s41... is a very troublesome paper. Either human embryos are totally different from other mammals or there is a problem with this specimen. In either case @Nature should have been cautious.
Epiblast diversification and blood formation in a human pregastrula - Nature
High-resolution spatial transcriptome analysis of a human embryo at Carnegie stage 6 reveals three distinct developmental trajectories from the epiblast towards amnion, primitive streak and axial meso...
nature.com
Impressive bench to bedside, Agnete Kirkeby, promise of pluripotent cell technologies. To end our 2-week course, a dinner cruise on the Seine. Magical evening, great company, students and instructors made this a successful and fruitful exchange of ideas. Thanks to all! See you in 2027 #ASCB course!
Matthias Lütolf engineered his way through organ regeneration with impressive micropatterns/microfluidics/imaging - to recapitulate growth and oncogenesis.
A travel through development and tumour biology with Cédric Blanpain, the power of lineage tracing, modelling and imaging! Then chick and quail: Charlène Guillot with Olinda Alegria-Prevot - ex ovo electroporation of embryos - viewing segmentation/growth, beautiful to watch!
2nd week of #ASCB! Evolution of regeneration, Eve Gazave, hands-on Platynereis regeneration wonderfully demonstrated, with help from Zoé Velasquillo, Rémi Strehl. Francina Langa Vives and expert CIGM team had everyone try pronuclear injections + ES into blastocysts - steady hands of creation.
Fritz Kahn had an amazing eye to convey the beauty and magic of biology, Here, from “man in structure and function”, the way #evolution has shaped fish gills into various human organs. #Infographics before its time.
Wonderful time, as always, at #ASCB! Thanks @pasteur.fr @LabTajbakhsh , @zenlabpasteur A great course, an stimulating atmosphere, great students have & to cap it all, boat trip on the Seine against the backdrop of Paris. #Gastruloid module w/ @da40cambs
End of the first and full week #ASCB. Pondering, and exchanges on a research career, then ST's lecture @tajbakhshlab.bsky.social , isolation of muscle stem (satellite) cells + myofibre niche. Plate & wait. Quiescence to differentiation. Barbara Gayraud-Morel, with help from Liza Sarde - thanks!
Every creature leaves a mark on the Earth. And humans? We leave behind plastic bottles, packaging, containers, and trash. The saddest part is that we are the only species that understands the damage—yet we keep doing it. Our footprint should be one of responsibility, not pollution.
- In 1969, I changed my choice of PhD when I hear Antonio's talks (coming back from Caltech). He dazzled, astounded, seduced me. I became his first PhD student. Without him my life would have be very different.
fly paper broadcast@fly-broadcast.bsky.social · 2mo agoAntonio García-Bellido: A brief history of flies, lineages, and a new developmental genetic logic #Drosophila
I will never get over how good this is! Already on day 3 of @bacell3d.bsky.social organoid conference - great science and discussions, as always!
Our Stem Cell Course #ASCB is back! After 2nd day, @institutpasteur.bsky.social @tajbakhshlab.bsky.social, @zenlabpasteur.bsky.social, Barbara Gayraud-Morel, and great interactive students. Laurence Daheron, Frank Yates, Michel Cohen-Tannoudji covered pluripotency and generating hiPSCs. Great team!
IMPORTANT study from @hocinerekaik.bsky.social @denisduboule.bsky.social and a significant validation of SCBEMs, #gastruloids in particular, as a discovery tool www.biorxiv.org/content/10.6... 🧵
Reminds me of currency devaluation caused by mass printing of money in a futile attempt to bolster an economy. And our treatment of papers as “currency” in measuring a scientists productivity value has led to this situation.
