Cantorlab
@cantorlab.bsky.social
Our lab studies ssDNA gaps as the cause of BRCAness and investigates how these gaps create a therapeutic window for sensitizing cancer cells to anti-cancer therapies.
PARPi sensitivity without HRD isn’t a paradox if you measure the right lesion. Inherent Gaps + active PARP1 = PARPi sensitivity doi.org/10.1158/0008...
Detection of Single-Stranded DNA Gaps Reveals a Functional Biomarker of Therapeutic Response
AbstractSingle-stranded DNA (ssDNA) gaps represent an underappreciated vulnerability that directly shapes therapeutic response in BRCA-deficient models. Current clinical biomarkers remain anchored to ...
doi.org
Happy to share a new publication on Mechanistic Coupling of Enzyme Activities at the Replisome in JBC. We #Traklab compare and contrast strategies used across organisms to coordinate the many enzymatic processes that occur during DNA replication. Hope it is helpful. doi.org/10.1016/j.jb...
Enjoying Brisbane from TRI seminar to Felons brewery with Kum Kum Khanna and MathewJones.
9 days to go: * 2 x open positions! * Exceptional environment, competitive start-up package * University of Toronto appointments * Toronto has great (and peaceful) quality of life!
Daniel Durocher@durocher1.bsky.social · last yr.JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!
Happy to share new work from my lab by co-authors Peng and Lee-when BRCA1 is absent, RAD51 is busy authors.elsevier.com/sd/article/S...
Wrapping up an insightful conference on DNA Replication Gaps, Cancer, and Disease! 🎉 Congrats to our Future of Science Fund winners, Larissa Milano and @seppai99.bsky.social! Your achievements inspire us. 🌟 #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together! @albertociccia.bsky.social @labvincenzo.bsky.social
Submit poster abstracts by 4/3, 11:59pm MST for DNA Replication Gaps, Cancer, and Disease in Daejeon, South Korea. Join experts to explore DNA errors and cancer. keysym.us/KSDNARep25. youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
KSQA: Dr. Kyungjae Myung (DNA Replication Gaps)
YouTube video by KeystoneSymposia
youtu.be
Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability. doi.org/10.1093/nar/...
I was very sad to learn of the passing of Mike Volkert, brilliant scientist always with kind smile...obit is posted www.umassmed.edu/maps/
Department of Microbiology
The Department of Microbiology was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology.
umassmed.edu
Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td
Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability
Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...
rdcu.be
Please join the conversation and get your abstract in!
Keystone Symposia@keystonesymposia.bsky.social · 2y agoJoin Helle D. Ulrich & experts this April to explore DNA replication errors, breaks, repair, and cancer! Submit abstracts and scholarships by Jan. 28 (11:59pm MST)! keysym.us/KSDNARep25 #KSDNARep25 #DNAreplicationgaps @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
Groundbreaking, first ever meeting dedicated to DNA GAPS 📅 Save the Date: April 27-30, 2025 | Daejeon, South Korea www.keystonesymposia.org/conferences/...
DNA Replication Gaps, Cancer and Disease | Keystone Symposia
Join us at the Keystone Symposia on DNA Replication Gaps, Cancer and Disease, April 2025, in Daejeon, with field leaders!
keystonesymposia.org
