Daniel Durocher
@durocher1.bsky.social
Scientist: durocherlab.org @ Lunenfeld-Tanenbaum Research Institute, Toronto. Founder: Repare Therapeutics & Induxion Therapeutics
Basal-like breast cancer has poor outcomes because we did not know which genes drove it. LTRI-led study out now in @nature.com reveals 81 new genes driving the disease in a major first step towards targeted therapy. 🧬 Read the story➡️ bit.ly/4vohaZY #BLBC
Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.
SLX4IP acts as a genome-wide brake on BLM helicase activity to preserve replication fork stability under stress – both globally and at ALT telomeres Stephanie Panier @spanier55.bsky.social, Kavi Mehta @k4v1.bsky.social and coworkers link.springer.com/article/10.1...
SLX4IP limits replication stress globally and at ALT telomeres - The EMBO Journal
Faithful DNA replication is essential for genome stability, yet replication forks face constant stress. The Bloom syndrome helicase (BLM) safeguards fork integrity, but excessive BLM activity can itse...
link.springer.com
We are so excited to see our work out in @nature.com! We present a multi-omic single-cell atlas of 12 organs in human fetal development, explore the enhancer landscape, use deep learning to infer rules of transcription factor activity, and interpret non-coding variants in complex traits: #GeneReg 🧬🖥️
John Greally@greally.bsky.social · 4mo agoThis @anshulkundaje.bsky.social, Kyle Fahr and William Greenleaf paper is finally out, we've been following it for a while in its preprint form, phenomenal work. www.nature.com/articles/s41...
Great conference, great science and great location!
Ross Chapman@rosschapmanlab.bsky.social · 4mo agoExcited to announce: the EMBO Workshop: DNA damage response in cell physiology & diseases - 12–16 Oct 2026 - in stunning Sounio, Greece - fabulous speaker speaker lineup representing the cutting-edge of genome stability research: Abstract deadline: 17 May meetings.embo.org/event/26-dna... Join us!
Maple syrup under a microscope. That is why Canadians are so happy, we literally eat glitter. 😊 #Canada
Fresh off the press, my latest YouTube extravaganza, sponsored by the Wendover tourist board
Britain's most controversial farm track
YouTube video by The Value of Nothing
m.youtube.com
The most important #RNA conference of the year with lots of amazing science and a really friendly atmosphere. This year in beautiful Montreal 🇨🇦 ! www2.rnasociety.org
RNA Society
www2.rnasociety.org
📣 The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open) 🗓 May 30–31, 2026 ✨ Talks will be selected from abstracts, with a strong focus on trainees and new investigators. Please RT & share with your labs! 🔗 sites.google.com/view/kumc-mi...
Great response so far for the DNA Repair Meeting in April 2026 ! 🧬 A few poster spots are still available. ✨ Early-bird registration extended to February 28th ✨ New invited speakers added: check the site: dnarepairmeeting-egmond2026.com Don’t miss this outstanding meeting!
To all DNA repair aficionados 🧬 who want to attend the Egmond Repair Meeting in April 2026: The deadline for early registration is January 10th, 2026! 🗓️ Sign up soon to benefit from the early-bird registration fee 🐦💸 See you all in Egmond! 🌊✨
Luijsterburglab@luijsterburglab.bsky.social · 9mo agoRegistration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com
That will be fun to explore!
Ernst Schmid@ernstschmid.bsky.social · 9mo agoThrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
How can we scale subcellular spatial proteomics across many experiments and conditions? Our new paper presents a genetic algorithm and evaluation framework that optimizes bait subsets for proximity proteomics platforms like BioID enabling context-specific proteome mapping.
9 days to go: * 2 x open positions! * Exceptional environment, competitive start-up package * University of Toronto appointments * Toronto has great (and peaceful) quality of life!
Daniel Durocher@durocher1.bsky.social · 11mo agoJOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!
Kickstarting our Bluesky🦋 account with great news! Our REPAIRome study finally out today in @science.org www.science.org/doi/10.1126/...
A comprehensive genetic catalog of human double-strand break repair
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...
science.org
We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
Investigating the interplay between DNA damage repair mechanisms, genomic instability and radiotherapy resistance - CRUK RadNet
Investigating the interplay between DNA damage repair mechanisms, genomic instability and radiotherapy resistance Primary supervisor: Sarah McClelland, Queen Mary University of London Secondary superv...
crukradnet.colcc.ac.uk
CRUK Radiation Research City of London Centre @cruk-rrc-col.bsky.social · 10mo agoInterested in carrying out research in cancer Radiotherapy and Radiobiology? Applications are open now for our PhD programme for 2026 intake! @kingscollegelondon.bsky.social @qmbci.bsky.social @crick.ac.uk @ucl.ac.uk crukradnet.colcc.ac.uk/phd-students...
I really wonder what a $2K set of peanut butter jars from the NATIONAL INSTITUTES OF STANDARDS & TECHNOLOGY could be for?
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data! Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models. Start mining data now: dataminer.depmap.sanger.ac.uk
Happy to share our latest research on the BRCA1-BRCTs now online. academic.oup.com/nar/article/... Congrats to first author Venda for putting it all together! This project was a great collaboration with the @titiasixma.bsky.social lab who helped us give structural meaning to our observations.
Validate User
academic.oup.com
New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n www.biorxiv.org/content/10.1...
Mitotic single-stranded DNA suppression by DDIAS
Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...
biorxiv.org
Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...
DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis
DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...
biorxiv.org
Job Alert 🚨 Are you an emerging leader in biomedical discovery or population health data science? We are looking for outstanding candidates to join our institute! Learn more & apply: Biomedical Discovery ➡️ apply.interfolio.com/172703 Population Health Data Science ➡️ apply.interfolio.com/172529
New from @hartjackson.bsky.social: 104‑plex #IMC on 3 serial PDAC sections, 200+ patients, whole-slide & cellular modes. Spatial proteomics guides LCM + genomics to define tumor–immune–stromal spectra. A tour de force. biorxiv.org/content/10.1... @standardbiology.bsky.social #SpatialBio #IMC
Integrated spatial proteomics of human PDAC uncovers an expanded tumour–immune– stroma spectrum with genomic associations
Distinctively, pancreatic ductal adenocarcinoma (PDAC) consists of sparse tumour lesions intertwined with extensive desmoplastic stroma. The complexity of tumour–microenvironment interactions within t...
biorxiv.org
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!
Welcome Alissa! We are very excited to have you with us!
alissa greenwald@alissacg.bsky.social · 12mo agoI'm thrilled to share that I'll be starting my lab (www.greenwald-lab.org) at the Lunenfeld-Tanenbaum Research Institute @sinaihealth.bsky.social and joining @moleculargenetics.bsky.social at the University of Toronto as an assistant professor this fall. 1/
I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌 www.cell.com/molecular-ce...
Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress
Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone mH2A1.2 ubiquitination in p...
cell.com