In this Outlook, Lee Zou discusses the new work by Seppa et al., comparing single-strand and double-strand DNA repair mechanisms in BRCA mutant cancers. #OpenAccess Read the Outlook here: ➡️ tinyurl.com/gd352827 Read the full story here: ➡️ tinyurl.com/gd352421

Genes & Development@genesdev.bsky.social · last yr.

In this study, Seppa et al. dissect the mechanisms by which DNA nucleases resect single-strand DNA gaps and regulate repair kinetics, with critical implications for BRCA1-deficiency and PARP inhibitor sensitivity. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352421

In this study, Seppa et al. dissect the mechanisms by which DNA nucleases resect single-strand DNA gaps and regulate repair kinetics, with critical implications for BRCA1-deficiency and PARP inhibitor sensitivity. #OpenAccess Learn more here: ➡️ tinyurl.com/gd352421

Still can’t believe the “DNA Replication Gaps, Cancer and Disease” Keystone Symposia is done! Grateful that Keystone thought my work was important enough to provide me with the Future of Science Fund scholarship to present my work.

Keystone Symposia@keystonesymposia.bsky.social · last yr.

Wrapping up an insightful conference on DNA Replication Gaps, Cancer, and Disease! 🎉 Congrats to our Future of Science Fund winners, Larissa Milano and @seppai99.bsky.social! Your achievements inspire us. 🌟 #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social

Super lucky to work with the best people who celebrate achievements in the yummiest way possible! Thank you @vindignilab.bsky.social @vermalab-washu.bsky.social 😊

An interesting collaboration with the @vindignilab.bsky.social on the mechanism of resection at gaps. Spoiler alert: the MRE11 complex acts very differently at gaps vs. at DNA breaks genesdev.cshlp.org/content/earl...

Really excited to share my co-first author paper with @cejkalab.bsky.social looking at how/which nucleases are involved in resecting ssDNA gaps generated by PARPi! Can’t wait to talk about our work at the DNA Replication Gaps, Cancer and Disease meeting in South Korea next month!

Vindigni Lab@vindignilab.bsky.social · last yr.

Check out our new paper led by @seppai99.bsky.social from the Vindigni Lab in collaboration with @cejkalab.bsky.social delving into the role of nucleases resecting ssDNA gaps generated by PARPi. You can read more here: genesdev.cshlp.org/content/earl...