#LRP1‑targeted #polymersomes reprogram #BloodBrainBarrier trafficking, enabling rapid #Amyloidβ clearance and sustained cognitive recovery in #AlzheimersDisease models. @beppebattaglia.bsky.social @ucl.ac.uk @icta-uab.bsky.social #CoverPage in #STTT: doi.org/10.1038/s413...
Beppe Battaglia
@beppebattaglia.bsky.social
ICREA Professor | Bioengineer @ IBEC-BIST Leading the Molecular Bionics Group—where physics, chemistry & biology converge to create future medicines. Motto: “The more I know, the less I know—yet all I want is to know how you know!” www.molecularbionics.org
A multivalent angiopep-2 polymersome that targets LRP1 in the BBB modulates receptor-mediated transport and biases LRP1 trafficking toward #Transcytosis to promote efficient Aβ removal. @beppebattaglia.bsky.social @ucl.ac.uk @icta-uab.bsky.social #OpenAccess: doi.org/10.1038/s413...
#PCBCommunity |🧠 Científics de @ibecbarcelona.eu aconsegueixen revertir l’ #Alzheimer en ratolins amb només tres injeccions de #nanopartícules per a restaurar la funció normal del sistema vascular en lloc d’actuar sobre les neurones o cèl·lules cerebrals, com s’ha fet fins ara. 💉🐁 👉 tuit.cat/iDeul
💡A RES Success Story to advance Neurodegenerative Disease Research💡 📋"LRP1's extended glycosylation may affect the protein's quaternary structure formation and stability" led by @beppebattaglia.bsky.social from @IBECBarcelona 🖥️ #Cibeles @uam.es 👉Full story: www.linkedin.com/feed/update/...
Very happy to share our latest #ACSNano work! www.linkedin.com/feed/update/...
#acsnano | Giuseppe Battaglia
Our latest work, published in #ACSNano and showcased in the issue cover, shows how to grow 2 nm gold nanoparticles inside polymersome membranes — not as decoration, but as engines. These tiny plasmoni...
linkedin.com
Out in @jmaterchem.rsc.org B. We’re excited to share our research on nanoparticle morphology! Check out our findings here: [Link](pubs.rsc.org/en/content/a...) #Nanomedicine #DrugDelivery
Morphological insights in oxidative sensitive nanocarrier pharmacokinetics, targeting, and photodynamic therapy
Nanoparticle (NP) morphology holds significant importance in nanomedicine, particularly concerning its implications for biological responses. This study investigates the impact of synthesizing polymer...
pubs.rsc.org
🚨 PhD Opportunities at IBEC! 🚨 Join #IBEC, a Severo Ochoa Research Centre, and start your research career with one of 12 fully-funded PhD fellowships in bioengineering! 🌟
Matter still remains, reshuffled like a deck—yet life’s flush is now gone.
🆕 We’re now on BlueSky! 🌐✨ Follow us for the latest updates in #bioengineering, groundbreaking #research, and inspiring initiatives from #IBEC. 🎓🔬 We’ll share engaging content in English, Catalan, and Spanish. Stay tuned and let’s explore together! 🚀
A Cixin Liu inspired haiku. -Vast universe swells, light too frail to span its reach— limbs lost to the void.
How did the universe start? A question without answer. But how about a different question, what’s time? And now if we have time we have a start if we don’t we don’t. Again no answer.
🎥 Watch Dr. Carla Garcia-Cabau, the first author of the study, along with Dr. Anna Bartomeu, explain the details of this research work. ▶️ youtu.be/KPrxBSPQ03o #IRBScience
🗣️Dr. @xsalvatella1.bsky.social: "In this study, we’ve discovered that this neuronal microexon is crucial for maintaining the condensates' stability & dynamics formed by #CPEB4 in neurons. Without it, condensates are less dynamic and can form solid aggregates that don’t work correctly."
🫧🔍Key breakthrough in #autism: pivotal role of #CPEB4 condensates revealed. 💊The study opens new avenues for the development of targeted treatments for autism. 📰 Nature @natureportfolio.bsky.social ✍️ Carla Garcia-Cabau, Anna Bartomeu et al. ➡️ bit.ly/3BfEGlR 📌 DOI: 10.1038/s41586-024-08289-w