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Luis E. Valentin-Alvarado

@luisvalentin.bsky.social

HFSP Research Fellow studying microbes, mobile DNA & RNA-guided immune systems.

35 Posts601 Follower330 Folgt
Simon Roux@simrouxvirus.bsky.social · last wk.

Reminder, registration for the Viral EcoGenomics & Applications (VEGA) 26 symposium is open ! See jgi.doe.gov/work-with-us... for more information

VEGA Symposium | Joint Genome Institute

Berkeley, CA

jgi.doe.gov

Simon Roux@simrouxvirus.bsky.social · 2mo ago

🚨 Registration for VEGA26 is 👏 officially open 👏 🚨 The 5th edition of our Viral EcoGenomics and Applications symposium will be held November 18-19, 2026, on the UC Berkeley campus 🧬 🦠 🔬 🧫 Event website ➡️ jgi.doe.gov/work-with-us... Registration link ➡️ cvent.me/e0RnA0

This image shows the VEGA logo (an Earth-shaped capsid colored with green continents and blue oceans), and the taglines: "VEGA Viral EcoGenomics & Applications", "Symposium hosted by the DOE Joint Genome Institute", "Novermber 18-19, 2026"
Chung Hyun Cho@chc-evobio.bsky.social · last mo.

Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...

Emergence of histone-based chromatin complexity in Asgard archaea

The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...

biorxiv.org

Kevin Forsberg@kvnforsberg.bsky.social · last mo.

Humans and bacteria share strategies to defend against viruses. We wondered: could they use each other's genes? Yes, both can! Bacteria can use human immune genes to defend against phages AND Human cells can use bacterial genes for viral defense. www.biorxiv.org/content/10.6...

Bacterial and human exonucleases mediate interkingdom antiviral immunity

All kingdoms of life have developed strategies to limit viral infection. In humans, interferons induce a suite of antiviral factors that collectively provide immunity. Some human immune genes are homo...

biorxiv.org

Andrew Roger@andrewjroger.bsky.social · 2mo ago

1/ Our new paper in Systematic Biology "Modeling Site-and-Branch-Heterogeneity with GFmix" led by @cgpmcc.bsky.social describes improved ways to model compositional heterogeneity across both sites and branches—an important source of error in deep phylogenomics. doi.org/10.1093/sysb...

Modeling Site-and-Branch-Heterogeneity with GFmix

Abstract. Phylogenetic trees are often inferred from protein sequences sampled from diverse taxa across the tree of life. The compositions of these amino a

doi.org

Molecular Biology and Evolution@molbioevol.bsky.social · 2mo ago

@joshnhamm.bsky.social @ndombrowski.bsky.social @greening.bsky.social @luisvalentin.bsky.social et al. provide the first investigation into the enigmatic Terrarchaeota and insights into the evolution of high salt adaptation in Archaea. 🔗 doi.org/10.1093/molbev/msag091 #evobio #molbio #microbeSky

New lineages provide insights into the convergent evolution of extreme salt adaptation within symbiotic Archaea

Abstract. Environmental genomics has led to the discovery of many new lineages of archaea, including “DPANN” (or Nanobdellati), comprising organisms with s

doi.org

Malcolm White@mfwhite2.bsky.social · 3mo ago

As an editor at the Biochemical Journal, I'd love to see more papers submitted in the areas of bacterial immune systems / CRISPR / archaeal molecular biology / nucleic acid processing enzymes

Biochemical Society@biochemsoc.bsky.social · 3mo ago

Researchers at our Read & Publish institutions can benefit from fee-free OA publishing and access to read content in our journals. Not sure if your institution has signed up? Check out the full list on our website: https://ow.ly/yeH150Z0THn 🧪

Read & Publish When the threshold is met for institutional subscriber renewals, an annual decision is made to fully open titles and provide fee-free open access to authors
Kenneth Loi@kenjmloi.bsky.social · 3mo ago

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

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Doudna Lab@doudna-lab.bsky.social · 3mo ago

We present VIPR, a phage-encoded RNA-guided system that recognizes DNA with a noncontiguous code unlike CRISPR. Tiny, programmable, possibly ancestral to CRISPR immunity; VIPR is built around a striking RNA-DNA-DNA triplex.

Kenneth Loi@kenjmloi.bsky.social · 3mo ago

Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.

Mohammed AlQuraishi@moalquraishi.bsky.social · 5mo ago

New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

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Evan Groover@evangroover.bsky.social · 4mo ago

Excited to see the major chapter of my PhD in print! We present a massively-parallel approach for screening CRISPR edits in plants to speed up agricultural test cycles + benchmark genomic LMs. Thanks to my fantastic co-authors and advisors. Link below!

Savage Lab@savagecatsonly.bsky.social · 4mo ago

Can CRISPR edits enable precise tuning of plant gene expression? We think: yes. In our newest manuscript, we measured the effects of >30,000 CRISPR-like promoter mutations in sorghum protoplasts.