1/11 New preprint from the Sternberg lab in collaboration with the Fernández lab! We are excited to share our structure-function study of DRT10, a bacterial defense-associated reverse transcriptase that synthesizes long tandem-repeat DNA.🧵 Read the full story here: www.biorxiv.org/content/10.6...

Mechanism of tandem-repeat DNA synthesis by an antiviral reverse transcriptase

Defense-associated reverse transcriptases (DRTs) employ DNA synthesis to protect bacteria against phage infection[1][1],[2][2]. We previously showed that DRT10, a tripartite system comprising an RT, a...

biorxiv.org

Had a blast putting this video abstract together with colleagues for @zjmaggiexu.bsky.social story in @currentbiology.bsky.social on how the "vampire cell" P. collini builds the perfect feeding trap 👀. Be sure to check out the full paper: www.cell.com/current-biol... www.youtube.com/watch?v=Ikzm...

A cellular vampire builds the perfect feeding trap / Curr. Biol., June 24, 2026 (Vol. 36, Issue 14)

YouTube video by Cell Press

youtube.com

Our updated full story on suctorian trap structure adaptation now online in @currentbiology.bsky.social! Huge thanks to Scott and all the co-authors for all the wow moments along the way! Also, if you’d like some new #protist #suctorian, let’s know! (They are surprisingly easy roommates/predators) 🤠

Scott Coyle@cellraiser.bsky.social · 4mo ago

@zjmaggiexu.bsky.social's story on suctorian trap structure adaptation is now online in @currentbiology.bsky.social , with new evolutionary analyses and modeling! This fall, Maggie will keep exploring predatory protists as a PD in @nbellono.bsky.social group; keep an eye out for her she's amazing!

I am honored and grateful to be selected as a 2026 Jane Coffin Childs Postdoctoral Fellow! I hope to continue doing exciting research!

Jane Coffin Childs Fund for Medical Research@jcchildsfund.bsky.social · 4mo ago

We are thrilled to announce our 2026 Jane Coffin Childs Fellows! These thirty-two outstanding scientists are performing cutting-edge research to advance our understanding of human diseases such as cancer, neurodegeneration, autoimmunity, pathogenic infections, and more. 1/3

Congratulations to Coyle-Lab alum @born2raisecell.bsky.social (now in Kole Roybal's lab at UCSF) on being selected for this! Very well-deserved -- can't wait to see what you do next

Jane Coffin Childs Fund for Medical Research@jcchildsfund.bsky.social · 4mo ago

We are thrilled to announce our 2026 Jane Coffin Childs Fellows! These thirty-two outstanding scientists are performing cutting-edge research to advance our understanding of human diseases such as cancer, neurodegeneration, autoimmunity, pathogenic infections, and more. 1/3

@zjmaggiexu.bsky.social's story on suctorian trap structure adaptation is now online in @currentbiology.bsky.social , with new evolutionary analyses and modeling! This fall, Maggie will keep exploring predatory protists as a PD in @nbellono.bsky.social group; keep an eye out for her she's amazing!

Scott Coyle@cellraiser.bsky.social · 11mo ago

How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926

Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...

Watching reaction-diffusion signaling couple to protein condensations feels like opening a new world of exotic subcellular spatial patterning 🌌 huge thanks to the evolving idea started from @edenchang.bsky.social and @cellraiser.bsky.social that make this journey possible and incredibly fun!

Scott Coyle@cellraiser.bsky.social · 4mo ago

Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...

Excited to share our new bioRxiv preprint! We introduce RIPPLE, a synthetic platform that couples reaction–diffusion signaling with protein condensation to generate tunable intracellular architectures. Grateful to @zjmaggiexu.bsky.social and @cellraiser.bsky.social. It’s been a rewarding journey.

Scott Coyle@cellraiser.bsky.social · 4mo ago

Sub-cellular architectures arise through integrating signaling and structure. @edenchang.bsky.social and @zjmaggiexu.bsky.social show how coupling reaction-diffusion signaling to protein condensation provides a tunable, regulatable landscape for sub-cellular structure www.biorxiv.org/content/10.6...

Join us for Zhejing (Maggie) Xu's Ph.D. thesis defense on May 11! As a member of the @cellraiser.bsky.social Lab, Xu studied how predatory protozoa adapt cell morphology to optimize feeding efficiency in response to environmental demands. Learn more: ipib.wisc.edu/2026/04/17/i...

IPiB Thesis Defense May 11, 2026: Zhejing “Maggie” Xu

Xu’s research in the Coyle Lab sought to understand how subcellular structures self-organize.

ipib.wisc.edu

Excited that our paper on enzymatic bromination of peptides is now online at ACS Chemical Biology! Led by Haley Bridge, we showed that the flavin-dependent halogenase RebH and its variants can be used for late-stage chemoenzymatic diversification of bioactive peptides: pubs.acs.org/doi/10.1021/...

Enzymatic Bromination of Native Peptides for Late-Stage Structural Diversification via Suzuki–Miyaura Coupling

Flavin-dependent halogenases (FDHs) provide a biocatalytic approach for the site-selective halogenation of aromatic compounds, but their use in late-stage functionalization of peptides has remained li...

pubs.acs.org

Huge congratulations to the recipients of the 2026 Harold M. Weintraub Graduate Student Award! These twelve exceptional graduate students exemplify the bold, creative, and pioneering spirit embodied by Dr. Hal Weintraub. www.fredhutch.org/en/news/rele...

Huge congratulations to my student Rohith Rajasekaran @born2raisecell.bsky.social (now a postdoc in Kole Roybal's lab at UCSF) on being selected for a Weintraub award! Super proud of you and all the work you've done!

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org · 8mo ago

Huge congratulations to the recipients of the 2026 Harold M. Weintraub Graduate Student Award! These twelve exceptional graduate students exemplify the bold, creative, and pioneering spirit embodied by Dr. Hal Weintraub. www.fredhutch.org/en/news/rele...

Thrilled to share our work on the 🔥 single-celled predator Podophrya collini, which rewires its cell morphology to hunt more efficiently. Huge thanks to our amazing team—Amy, Lauren, Omaya, Marine, Mari, and especially Scott—for making this shine! ✨

Scott Coyle@cellraiser.bsky.social · 11mo ago

How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926

How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926

Join us for Rohith Rajasekaran's (@born2raisecell.bsky.social) PhD thesis defense on Friday, Nov. 21! Rajasekaran's research was completed in the Coyle Lab (@cellraiser.bsky.social). More info: today.wisc.edu/events/view/...

New preprint: we developed a method that uses phosphoproteome-derived peptide libraries (PhosPropels) for deep specificity profiling of phosphatases and phospholyases www.biorxiv.org/content/10.1...

Excited to share a new preprint! Wireless devices use FM modulation to transmit multiplexed noise-resistant data. Led by @born2raisecell.bsky.social, we create a biochemical analogue of this paradigm using genetically encoded oscillators (GEOs) for single-cell FM streaming tinyurl.com/nbs8rw42 🧵