A cross sectional analysis on lab data from 2 independent cohorts reveals that the final menstrual period marks an abrupt, multisystem physiological shift, occurring 10 years before menopause onset. @urialonlab.bsky.social

Population-scale reconstruction of menopause dynamics reveals a physiological cliff at the final menstrual period - Nature Medicine

By using a novel computational framework, a cross-sectional analysis on laboratory data from two independent cohorts reveals that the final menstrual period marks an abrupt, multisystem physiological shift, with sex hormone changes beginning more than 10 years before menopause onset.

dlvr.it

I spoke with @nakedscientists about our Nature Medicine paper: menopause is like a physiological cliff. Many systems jump at the final period, some with early signs a decade before. Hormone therapy seems to soften the cliff, so timing matters. From 20:45: www.thenakedscientists.com/podcasts/nak...

What is menopause, and how can you manage it?

Plus, how cutting-edge research is shaping our understanding

thenakedscientists.com

Our Nature Medicine paper is out: menopause isn't a slow slope. Across 300M+ lab tests from 1M+ women, many body systems jump at the final menstrual period. Men show no such jump. 1/4 www.nature.com/articles/s41...

Population-scale reconstruction of menopause dynamics reveals a physiological cliff at the final menstrual period - Nature Medicine

By using a novel computational framework, a cross-sectional analysis on laboratory data from two independent cohorts reveals that the final menstrual period marks an abrupt, multisystem physiological ...

nature.com

Excited to be speaking at the 2026 Biomarkers of Aging Conference, October 5-6, at Harvard Medical School's Joseph B Martin Conference Center. www.agingconsortium.org/2026-confere...

Happy to share that I was named one of TIME’s 2026 Longevity Leaders. Our work uses physics-style theory to look for simple principles that can explain the complex dynamics of aging. x.com/UriAlonWeizm...

Uri Alon (@UriAlonWeizmann) on X

Happy to share that I was named one of TIME’s 2026 Longevity Leaders. Our work uses physics-style theory to look for simple principles that can explain the complex dynamics of aging. https://t.co/Y7Kc...

x.com

Why do animals age in such similar ways, yet live for wildly different spans - from days to a century? Our new paper in @NatureAging fits a damage accumulation model across 9 species and finds the knob that best predicts lifespan doi.org/10.1038/s435...

A damage accumulation model identifies distinct aging regimes across species - Nature Aging

Raz and colleagues fit survival data across species to a stochastic model of damage accumulation and removal. They report that damage production rate best predicts lifespan and reveal two distinct agi...

doi.org

What happens just before we die? Are the last stages of deterioration driven by different dynamics, or the same processes driving aging all our lives? Turns out it's the latter, as we show in our new preprint! 🔬 doi.org/10.64898/202... 🧵 1/5 #AgingResearch #SystemsBiology

Identify. Attack. Resolve. The immune system follows a perfect defense program: ignore weak/self signals, attack true threats with force, then shut down to avoid damage. (1/2) www.science.org/doi/10.1126/...

Excitability as a design principle in the immune system

A simple pulse-and-rest circuit may explain how immune cells strike hard at threats yet avoid self-destruction.

science.org

Recommended listening. I was hosted on the podcast “Gil Hameever” to discuss our latest paper about the sudden physiological changes at menopause. The conversation is in Hebrew. open.spotify.com/episode/0EVA...

פרק 36: חשיפת בכורה של מחקר פורץ דרך של מכון ויצמן בנושא מנפאוזה

open.spotify.com

We analyzed changes in physiology relative to menopause using two large scale studies that include millions of lab tests. Rather than align by age, we used statistical inference to align tests to final menstrual period. (1/2) arunamed.com/the-menopaus...

The Menopause Cliff: What a Million Women's Lab Tests Reveal

TLDR: A massive study of 300+ million lab tests from 1+ million women just proved what women have been saying for years: menopause isn't a gradual slope—it's a physiological cliff. Nearly e

arunamed.com

Why does innovative research necessitate a jump into the unknown? Find out (and much more) in episode 147 of רעב לידע עם אור דניאל (Hungry for Knowledge with Or Daniel)! www.learntech.co.il/podcast/pod1...

מדוע מדע חדשני דורש קפיצה אל הלא נודע? | פרופ' אורי אלון | פרק 147 · LearnTech

הכירו את פרופ' אורי אלון, מנהל מעבדת סגול לאריכות ימים במכון ויצמן. בפרק מרתק זה תגלו מדוע תסכול וכישלון הם לא רק חלק מהמחקר אלא המפתח לגילויים פורצי דרך, איך "ענן המחקר" יכול להפוך מאויב למדריך, ומה ...

learntech.co.il

Sweet moment in life, our 25th lab anniversary. In a circle, we looked at each other, a group of people with shared values and a soft approach, who want each other to succeed and be happy. (1/2)

Masterpiece by a masterful scientist Natural Neuroscience by Nachum Ulanovsky @mitpress.bsky.social mitpress.mit.edu/978026204499...

Our latest on aging, where we reveal an unexpected link between healthspan and equality of lifespans. By @y1fanyang.bsky.social , out now @naturecomms.bsky.social www.nature.com/articles/s41...

Compression of morbidity by interventions that steepen the survival curve - Nature Communications

Longevity research aims to extend lifespan and reduce sickspan in aging. Here, the authors show that only interventions that steepen survival curves can compress the sickspan relative to lifespan.

nature.com

Now in French and Spanish - our pregnancy paper is highlighted also in @lefigaro.fr and @elpais.com sante.lefigaro.fr/medecine/com... elpais.com/salud-y-bien...

Comment la grossesse chamboule le corps de la future mère, et pourquoi elle ne redevient jamais vraiment elle-même

Une étude menée sur plus de 300 000 femmes révèle les bouleversements visibles dans le sang et l’urine des femmes enceintes. Des résultats qui pourraient aider à mieux prédire les complications de la ...

sante.lefigaro.fr

Amazing clinical epidemiology! The power of numbers! @urialonlab.bsky.social www.nature.com/articles/d41...

Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet

Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

nature.com

We now have our most detailed picture yet of how pregnancy affects the body on a weekly basis from 20 weeks pre-conception to 1.5 years after delivery. Fab work from @urialonlab.bsky.social Read @newscientist.com. www.newscientist.com/article/2473...

Pregnancy’s lasting effects on different parts of the body revealed

An "unprecedented view" of how the body changes during and after pregnancy has revealed many long-lasting impacts on the liver, kidneys and more

newscientist.com

"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet" Our study highlighted in @nature.com News www.nature.com/articles/d41...

Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet

Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

nature.com

Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.

Harnessing huge data from pregnancy natural experiments @urialonlab.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

Theory predicted two kinds of fibrosis, hot and cold. We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social

Shoval Miyara@shovalmiyara.bsky.social · 2y ago

Our work made it to the cover of @cp-cellsystems.bsky.social ! 🥳 Cold and hot fibrosis define clinically distinct cardiac pathologies www.cell.com/cell-systems... Special thanks to Danielle Kimchi for creating this beautiful cover! 🎉 @urialonlab.bsky.social @eldadtzahor.bsky.social

Sagol lecture in longevity research - Myriam Grunewald on vasculature maintenance for longevity

Join us at the ICSB in Dublin this October - I will chair the session on aging systems biology icsb2025.com

It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...

Cold and hot fibrosis define clinically distinct cardiac pathologies

Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,” involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven “cold fibrosis,” contr...

cell.com

My brilliant PhD student @Yaelebel.bsky.social gave a talk at the Azrieli Graduate Students forum about her research on using excitable dynamics to explain pulsatile immune phenomena, and how research questions can come from the most unexpected places. Well done Yael! youtu.be/MdwqWx5emo4

Yael Lebel

YouTube video by Azrieli Fellows Program

youtu.be

Will be attending the Quantitative Immunology workshop at the Princeton Center for Theoretical Science later month. pcts.princeton.edu/events/2025/...

Why do cortisol-lowering drugs work for Cushing’s but fail in mood disorders & chronic stress? We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)

@urialonlab.bsky.social lab reveals a hormone circuit that explains why most HPA drugs fail for mood disorders and predicts the few that work ➡️ www.embopress.org/doi/full/10....

Really enjoying Uri Alon’s characteristically wonderful lectures on aging: www.weizmann.ac.il/mcb/alon/cou...

Videos and lecture notes from my latest course, Systems Aging, are available now at: www.weizmann.ac.il/mcb/alon/cou...