Excited to announce the final versions of my paper on the role of the internal elastic lamina in resistance arteries and my review on pannexins in the vasculature are out! Thank you to the co-authors for your great work! Links below

Thanks to @UVACVRC for the shoutout! Happy National Postdoc Appreciation Week 🎉

UVA CVRC@uvacvrc.bsky.social · last yr.

Brooke O'Donnell, PhD, works at the molecular level to understand how Pannexin proteins affect blood pressure, blood flow, and blood vessel dilation. @brookeodonnell.bsky.social is also a hockey player, reader, and the @brantisakson.bsky.social Lab's resident tea evangelist.

The official release of our manuscript examining arterial myocyte Panx1 role in diabetic vascular dysfunction is out! Massive effort to uncover new mechanisms underlying vascular disease. Power of science! @ucdavis.bsky.social, @ucdavispharm.bsky.social www.ahajournals.org/doi/10.1161/...

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia | Circulation Research

BACKGROUND: Diabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y11L (P2Y11-like receptor)/AC5 (adenylyl cyclase 5)/AKAP5 (A-kinase anchoring protein 5)/PKA (protein kina...

ahajournals.org

Grateful to have been a part of this exciting story!

Manuel F. Navedo@mfnavedo.bsky.social · last yr.

Excited to pre-release the latest from the lab on how arterial myocyte Panx1 controls vascular reactivity in diabetes. Massive effort from the M&M Team in collaboration with @brantisakson.bsky.social and Xiang Lab

Some of the strong work by Melissa Luse rounding her PhD. Love the story, and I think it opens up some new ideas in endothelial lipid handling and overall questions roles for NO… www.ahajournals.org/doi/10.1161/...

Nitrosation of CD36 Regulates Endothelial Function and Serum Lipids | Arteriosclerosis, Thrombosis, and Vascular Biology

BACKGROUND: During obesity, endothelial cells (ECs) become lipid laden, leading to endothelial dysfunction. We tested posttranslational modification on CD36 that may regulate EC lipid accumulation. ...

ahajournals.org

Was great to be back for the 13th Conference on Signalling in Normal and Cancer Cells to present my work on the effect of PANX1 phosphorylation in the vasculature 🍁 thanks to the organizers @jf-cotelab.bsky.social for a great week and my previous lab mates @drsilviapenuela.bsky.social for the visit!