A direct synthesis of versatile active esters! Massive congratulations to Simon Kaltenberger, Joshua Meinshausen, @jyotirmoydey.bsky.social and Celia Sanchez-Gonzalez on the development of a widely applicable sterically controlled alkoxycarbonylation of arenes now in JACS Au doi.org/10.1021/jacs...

Today @jyotirmoydey.bsky.social defended his excellent work - well deserved doctorate! Congratulations and all the best for your upcoming future! #chemsky #proudPI

Access SEAr-type products in typically disfavored positions! Contratulatons to Rita, @jyotirmoydey.bsky.social and Elisa showin in Org. Lett. how nondirected C-H activation and oxidative cleavage can be used to obtain challenging regioisomers in formylation and carboxylation doi.org/10.1021/acs....

Hot off the press in Org. Lett.: Together with Rita, we show how two ligands control sterically favored nondirected C–H olefination. Combined with oxidative cleavage, this delivers challenging & complementary regioisomers. Thanks to Prof. @vangemmerenlab.bsky.social and all co-authors @uni-kiel.de

Sterically Controlled C(sp2)–H Carboxylation and Formylation: A Complementary Strategy to SEAr Approaches

Carboxyl- and formyl-substituted arenes are key motifs in organic chemistry, typically prepared via electrophilic aromatic substitution (SEAr) reactions. SEAr reactions hold tremendous synthetic value...

pubs.acs.org

In @science.org this week, THE @nagiblab.bsky.social makes all the carbenes (no, seriously!) and classifies their electronic properties on a common basis chemsky 🧪 www.science.org/doi/10.1126/...

Harnessing carbene polarity: Unified catalytic access to donor, neutral, and acceptor carbenes

Metal carbenes are highly useful intermediates in organic synthesis. However, not all classes of carbene polarity are catalytically accessible, nor are there common precursors known to synthesize all ...

science.org

Great job Edis and @sourjyamal.bsky.social! Their work on the synthesis of γ-Alkylidene Lactones has just been accepted for publication in the @rsc.org journal @chemicalscience.rsc.org doi.org/10.1039/D5SC...

Five years after reporting the direct acyloxylation of carboxylic acids, we could now finally achieve the direct hydroxylation, just out in Org. Lett. Huge congratulations to @sourjyamal.bsky.social and Tianxiao Xu! pubs.acs.org/doi/10.1021/...

Direct Pd-Catalyzed β-C(sp3)–H Hydroxylation of Aliphatic Carboxylic Acids

β-Hydroxy carbonyl scaffolds are of paramount importance due to their presence in a variety of natural products and bioactive molecules. In this study, we present a direct palladium-catalyzed β-C(sp3)–H hydroxylation of aliphatic carboxylic acids. The reported method employs convenient and readily available TBHP as an oxidant and provides an efficient, one-step route to a diverse range of β-hydroxy acids. Key aspects include the compatibility of this method with challenging α-non-quaternary carboxylic acids as substrates and excellent functional group tolerance. This newly developed method is expected to prove useful for generating compound libraries relevant to multiple disciplines.

pubs.acs.org

Massive congratulations to Jotirmoy Dey and Simon Kaltenberger who have developed a method for the deuteration of various heteroarenes using a multi-substrate screening! strategy. #proudPI

We start our first post on Bluesky with a firework! Very proud of a brilliant team to publish our work on C(sp3)-atom transfer @science.org. www.science.org/doi/10.1126/... It has been a very exciting journey. Thanks @erc.europa.eu

Super proud of Tianxiao Xu and Sourjya Mal @sourjyamal.bsky.social, who - after a more than half-year publication-process-odyssey - have published their method on the gamma-lactonization of carboxylic acids, including highly challenging beta-non-quaternary substrates doi.org/10.1021/acsc...

The Direct Pd-Catalyzed γ-Lactonization of Aliphatic Carboxylic Acids

A direct palladium-catalyzed γ-lactonization of free carboxylic acids via C–O reductive elimination as a key step is described. Notable aspects of this protocol include the use of convenient and easil...

doi.org

I’m an NSF panel reviewer that was scheduled to meet today. Just got notice that all NSF panels were canceled today. I reviewed some innovative proposals in support of students. Devastating if these scholars don’t get to do this work. For the love of science & students I hope this is just a delay.💔

Discover the game-changing late-stage C–H deuteration of organic compounds using ligand-enabled palladium-catalyzed hydrogen isotope exchange by Jyotirmoy Dey and Manuel van Gemmeren (@vangemmerenlab.bsky.social)! #PalladiumCatalysis 👉 www.thieme-connect.com/products/ejo...