Check out this excellent review by @sourjyamal.bsky.social on carboxylic acid directed C(sp³)–H functionalization, covering distinct mechanistic strategies (C–H activation, HAT, etc), catalyst design principles, and their applications in building complex molecules. doi.org/10.1021/acs....

Another major milestone has been achieved! Sourjya Mal presented an outstanding defense and has now well-deservedly earned the title of Dr. Mal!!!🎓 Congratulations from the van Gemmeren group, and all the best for your future journey!

Just one ''click'' away! Dive into our newest publication showcasing non-directed C-H olefination as a powerful tool to access versatile linchpins for bioconjugation and/or ABPP studies! doi.org/10.1002/chem.202600018 Congratulations to Tommaso Braga and @mariahergert.bsky.social !

A direct synthesis of versatile active esters! Massive congratulations to Simon Kaltenberger, Joshua Meinshausen, @jyotirmoydey.bsky.social and Celia Sanchez-Gonzalez on the development of a widely applicable sterically controlled alkoxycarbonylation of arenes now in JACS Au doi.org/10.1021/jacs...

Exttemely proud of this computational and experimental mechanistic work headed by @chimicafritz.bsky.social and supported by @monikaravi.bsky.social just out in @angewandtechemie.bsky.social doi.org/10.1002/anie... #chemsky

Access SEAr-type products in typically disfavored positions! Contratulatons to Rita, @jyotirmoydey.bsky.social and Elisa showin in Org. Lett. how nondirected C-H activation and oxidative cleavage can be used to obtain challenging regioisomers in formylation and carboxylation doi.org/10.1021/acs....

A simple, scalable method by Jurk & van Gemmeren @vangemmerenlab.bsky.social to convert secondary sulfonamides into sulfonyl fluorides using affordable #DAST ⚗️, yielding excellent results! These sulfonyl fluorides readily couple with amines to create diverse libraries. #SuFEx 👉 buff.ly/hjkyEap

The final version of our @vangemmerenlab.bsky.social 'Molecular Stitching' approach, enabling one-step access to a diverse library of γ-alkylidene lactones, is now out in @chemicalscience.rsc.org #MyFirstChemSci Link to the full article: doi.org/10.1039/D5SC...

Synthesis of γ-alkylidene lactones via molecular stitching of carboxylic acids and olefins

In this study, we describe a direct palladium-catalyzed tandem β-C(sp3)–H olefination/lactonization strategy for the one-step synthesis of γ-alkylidene lactones. The reaction is enabled by an N-acyl s...

doi.org

Congratulations to aol three @uni-kiel.de candidates who were selected to participate in the Lindau Nobel Laureate meeting. In particular of course our very own @sourjyamal.bsky.social. A well deserved recognition of his excellent doctoral studies. #proudPI #chemsky www.uni-kiel.de/de/detailans...

Drei Nachwuchsforschende der Uni Kiel bei Nobelpreisträger-Tagungen

Die Einladungen sind auch eine Auszeichnung für die Chemie und die Wirtschaftswissenschaften an der CAU.

uni-kiel.de

Great job Edis and @sourjyamal.bsky.social! Their work on the synthesis of γ-Alkylidene Lactones has just been accepted for publication in the @rsc.org journal @chemicalscience.rsc.org doi.org/10.1039/D5SC...

Just saw on the OL homepage that the article currently leads the journals most read list, thanks for all the interest in our work! pubs.acs.org/action/showM...

Check out our newest C(sp³)–O bond formation strategy: doi.org/10.1021/acs....

van Gemmeren Lab@vangemmerenlab.bsky.social · last yr.

Five years after reporting the direct acyloxylation of carboxylic acids, we could now finally achieve the direct hydroxylation, just out in Org. Lett. Huge congratulations to @sourjyamal.bsky.social and Tianxiao Xu! pubs.acs.org/doi/10.1021/...

Congratulations to Edis and @sourjyamal.bsky.social, who have completed their studies on a new and efficient approach towards gamma-alkylidene lactones directly from carboxylic acids and lactones now posted on @chemrxiv.bsky.social chemrxiv.org/engage/chemr... #chemsky #chemistry

Check out my latest preprint from @vangemmerenlab.bsky.social , where we disclosed a one-step approach to access γ-alkylidene lactones by stitching together aliphatic acids and styrenes, enabled by N-Acyl Sulfonamide ligand. doi.org/10.26434/che...

Synthesis of γ-Alkylidene Lactones via Molecular Stitching of Carboxylic Acids and Olefins

In this study, we describe a direct palladium-catalyzed tandem β-C(sp3)–H olefination/lactonization strategy for the one-step synthesis of γ-alkylidene lactones. The reaction is enabled by an N-acyl s...

doi.org

Thanks for all the interest in the study. It is now amongst the currently most read in ACS Catalysis

Smashing distal C–H bonds of the unprecedented β-non-quaternary acids has been a formidable task over the years; several years of our involvement in 'Ligand Design' finally broke the deadlock! Thanks to @vangemmerenlab.bsky.social for guiding us to achieve this feat !

van Gemmeren Lab@vangemmerenlab.bsky.social · 2y ago

Super proud of Tianxiao Xu and Sourjya Mal @sourjyamal.bsky.social, who - after a more than half-year publication-process-odyssey - have published their method on the gamma-lactonization of carboxylic acids, including highly challenging beta-non-quaternary substrates doi.org/10.1021/acsc...

We have developed a direct gamma-lactonization of carboxylic acids. The scope includes beta-non-quaternary subatrates that were until now out of reach for carboxylic acid gamma-C-H activation. Congratulations to Tianxiao and Sourjya. Have a look at the study now posted on ChemRXiv t.co/Wu0XtwsEQR

Our work on the direct fluorination of carboxylic acids has just appeared in @NatureSynthesis! (www.nature.com/articles/s44...). This terrific study bySourjya Mal, Friedrich Jurk, and Kerstin Hiesinger is highlighted in a press release by our University: www.uni-kiel.de/en/details/n...

Pd-catalysed direct β-C(sp3)–H fluorination of aliphatic carboxylic acids - Nature Synthesis

C–F bond formation using transition-metal catalysis is a challenge owing to the high energy barrier associated with reductive elimination. Now the direct β-C(sp3)–H fluorination of aliphatic carboxyli...

nature.com