Institute for Stroke and Dementia Research (ISD)
@isd-research.bsky.social
Welcome to the Institute for Stroke and Dementia Research (ISD) in Munich – Director: Prof. Martin Dichgans https://www.isd-research.de/
Congratulations! ISD researcher Jule Filler received the Young Investigator Award at the European Stroke Organisation Conference (ESOC) 2026 in Maastricht for her work "Early plasma NfL predicts cognitive outcomes 5 years after stroke" 👏👏👏 www.isd-research.de/isd-research...
🧠 Ein Team um @paquetlab.bsky.social vom @isd-research.bsky.social des @lmu-klinikum.bsky.social hat ein neuartiges 3D‑Gewebemodell entwickelt, das die komplexen Zusammenhänge im Gehirngewebe bei #Alzheimer real abbildet. Das könnte die Erforschung der neurodegenerativen Erkrankung voranbringen.
Alzheimer-Forschung: Modell bildet Hirngewebe in 3D ab
Wie lässt sich die Erforschung der Alzheimer-Demenz schneller, effektiver und besser machen? Nach Jahrzehnten intensiver Forschung weltweit und trotz jüngster therapeutischer Fortschritte ist es bisla...
healthcare-in-europe.com
Rolf Becker Prize for ISD Researcher Dominik Paquet and Angelika Dannert for their publication on a three-dimensional model of the human blood brain barrier developed entirely from induced pluripotent stem cells .. Congrats! @paquetlab.bsky.social
🏆 LMU Medical Scientist of the Year 2026: Dr. Naomi Vlegels wurde für ihre Forschung zu tau-Proteinen und Hirnschäden nach Schlaganfall ausgezeichnet. Im Video erzählt sie mehr über ihre Arbeit und ihre tägliche Inspiration. lmu-klinikum.de/scrivito/new...
LMU Medical Scientist of the Year 2026: Dr. Naomi Vlegels
Auf dem Jahresempfang der Medizinischen Fakultät der LMU wurde Dr. Naomi Vlegels vom Institut für Schlaganfall- und Demenzforschung für ihre Arbeit "Brain-derived tau for monitoring brain injury in ac...
lmu-klinikum.de
🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de published in @natneuro.nature.com: We developed a highly reproducible 3D human brain tissue model (3BTM) that enables studying microglial phenotypes in health and disease! #OA PDF here: rdcu.be/fxLou Thread👇: 1/11
ISD researchers found that the brain’s modular network organization influences how amyloid-driven tau pathology spreads. Published in Alzheimers&Dementia: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
ISD researchers investigated how plasma biomarkers (phosphorylated tau 217 [ptau217], glial fibrillary acidic protein [GFAP], neurofilament light chain [NfL]) relate to imaging markers of SVD and AD, and cognition in memory clinic patients. -> doi.org/10.1002/alz....
www.nature.com/articles/s41...
A deep-learning framework reveals whole-body perturbations at cell level - Nature
An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia.
nature.com
The SFB 1744 / CRC 1744 website is now published www.sfb1744.de 🎊 It not only represents work, events, publications of the CCN in NVD network but furthermore offers a platform for the Graduate Program IRTG-BrainVasc including open PhD positions! www.sfb1744.de/sfb1744 www.sfb1744.de/open-positio...
Advanced Clinician Scientist Program for Comprehensive Neuroscience (PROMISE) www.med.lmu.de/de/wissensch...
CRC1744 Launch – Kick-off Event With the official launch of CRC1744 we welcomed principal investigators and early career researchers as well as distinguished guest speakers to a one-day kick-off meeting. www.isd-research.de/news/crc1744...
A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology | Science Translational Medicine www.science.org/eprint/5H5YD...
A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology
A human iPSC–derived tauopathy model endogenously recapitulates late-stage pathology and enables translational applications.
science.org
ISD Investigators have secured major funds from Germany’s Federal Ministry of Research, Technology and Space, to strengthen clinician-led, translational neuroscience research. PROMISE will support 12 competitively selected Advanced Clinician Scientists >> www.isd-research.de/scrivito/adv...
Image of the Week: Congrats to the team of González-Gallego J et al., Nat Neurosci. 2026 for this lovely award in Nature Briefing 🏆 🖼️ @judit-gonzalez.bsky.social @paquetlab.bsky.social (->Fig 2b www.nature.com/articles/s41...)
PaquetLab@paquetlab.bsky.social · 10mo agoNew paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 Thread👇 1/10
Frühe und verlässliche Diagnostik ist ein Schlüssel in der Alzheimer-Forschung. Dr. Anna Dewenter forscht am @isd-research.bsky.social der @lmu.de genau daran. In ihrem AFI-Projekt untersucht sie mithilfe moderner MRT-Bildgebung feine Veränderungen der weißen Hirnsubstanz.
Vollautomatisiertes Verfahren zur Diagnostik einer Alzheimer-assoziierten Gefäßerkrankung
YouTube video by Alzheimer Forschung Initiative
youtube.com
Brain-derived tau for monitoring brain injury in acute ischemic stroke - Great work by Steffen Tiedt, his team of ISD researchers and international partners now published in Science Translational Medicine: www.science.org/doi/10.1126/... 🎊🙌 #BD-tau #ischemic
Brain-derived tau for monitoring brain injury in acute ischemic stroke
Brain-derived tau in plasma reflects the extent of brain injury in acute ischemic stroke, predicts functional outcomes, and detects treatment effects.
science.org
New paper out today at @natneuro.nature.com in collab. with DichgansLab @isd-research.bsky.social @lmumuenchen.bsky.social: We developed a fully #iPSC-derived human model of the #BBB #blood-brain-barrier and applied it to study neurovascular disease (NVD)! #OA PDF here: rdcu.be/eUIl3 Thread👇 1/10
Congratulations! 🏆 The European Research Council has awarded the prestigious ERC Consolidator Grant to support TRAINED, a project led by Arthur Liesz (ISD) that investigates how maladaptive trained immunity drives systemic inflammation and multimorbidity after stroke and myocardial infarction.
German Research Foundation (DFG) has approved funding of a new CRC on “Compartmentalized Cellular Networks in Neurovascular Diseases”. Thanks to everyone involved!🙏 www.lmu.de/en/newsroom/...
Synaptic density and tau pathology in Alzheimer’s disease: a dual role in susceptibility and degeneration url: academic.oup.com/brain/articl...
Synaptic density and tau pathology in Alzheimer’s disease: a dual role in susceptibility and degeneration
Luan et al. used dual PET imaging to examine the relationship between synaptic density and tau pathology in Alzheimer’s disease. They show that synapse-ric
academic.oup.com
Happy to find Martin Dichgans on the list of Highly Cited Researchers™ once more 🎉 clarivate.com/highly-cited...
Key risk factors for post-stroke dementia uncovered: results from DEMDAS study identify metabolic syndrome + reduced HDL cholesterol as novel, modifiable risk factors for post-stroke dementia... www.thelancet.com/journals/lan...
Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease url: academic.oup.com/brain/articl... #tao @nfranzme.bsky.social
Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease
In Alzheimer’s disease, tau pathology not only contributes to cortical atrophy but also leads to the degeneration of white matter tracts that connect diffe
academic.oup.com
Marios Georgakis and team showed IL6 genetic perturbation mimicking IL-6 inhibition is associated with lower cardiometabolic risk www.nature.com/articles/s44...
Mikael Simons receives $500,000 for a project to investigate disease mechanisms involving tau proteins. The funding is part of the international program „Tauopathy Challenge Workshop 2025“, supporting research projects aimed at understanding and treating tau-associated diseases such as AD. 🎉
Annual ISD Research Retreat 🎆 Great talks, project presentations, poster session, games, guest talks and an amazing LLM workshop by Rainer Malik 🙏
Arthur Liesz received the prestigious ESO Scientific Excellence Award for his contributions to the understanding of stroke and neurovascular disease. The award was delivered in the Presidential Session at the European Stroke Organisation Conference (ESOC 2025) in Helsinki. @arthurliesz.bsky.social 👏
The Munich Cluster for Systems Neurology (SyNergy) has been awarded a third funding period (2026-2032) by the DFG. 🎆 👏 @synergy-munich.bsky.social
